tetraethylenepentamine-405 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tetraethylenepentamine-405 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADRBK2 adrenergic, beta, receptor kinase 2
AHI1 Abelson helper integration site 1
APOM apolipoprotein M
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ATAD2B ATPase family, AAA domain containing 2B
BICD1 bicaudal D homolog 1 (Drosophila)
C1ORF109 chromosome 1 open reading frame 109
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CADM3 cell adhesion molecule 3
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CFAP70 cilia and flagella associated protein 70
CLCN7 chloride channel, voltage-sensitive 7
CNTFR ciliary neurotrophic factor receptor
CTAGE9 CTAGE family, member 9
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
DENND3 DENN/MADD domain containing 3
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DLEC1 deleted in lung and esophageal cancer 1
DPP6 dipeptidyl-peptidase 6
DRP2 dystrophin related protein 2
EFNB3 ephrin-B3
FAS Fas cell surface death receptor
FKBP1A FK506 binding protein 1A, 12kDa
FLOT1 flotillin 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAS7 growth arrest-specific 7
GOLGA2 golgin A2
GP2 glycoprotein 2 (zymogen granule membrane)
HAP1 huntingtin-associated protein 1
HCG4B HLA complex group 4B (non-protein coding)
HOXC4 homeobox C4
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HUS1 HUS1 checkpoint homolog (S. pombe)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
JOSD1 Josephin domain containing 1
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIFC1 kinesin family member C1
KRT6B keratin 6B, type II
KRT8P12 keratin 8 pseudogene 12
LINC00574 long intergenic non-protein coding RNA 574
LMBR1L limb development membrane protein 1-like
LPIN2 lipin 2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY86 lymphocyte antigen 86
MAOA monoamine oxidase A
MPPE1 metallophosphoesterase 1
MRPS15 mitochondrial ribosomal protein S15
MYL10 myosin, light chain 10, regulatory
NCKIPSD NCK interacting protein with SH3 domain
NDRG2 NDRG family member 2
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NNAT neuronatin
NPAT nuclear protein, ataxia-telangiectasia locus
NR4A1 nuclear receptor subfamily 4, group A, member 1
NREP neuronal regeneration related protein
OMG oligodendrocyte myelin glycoprotein
OPCML opioid binding protein/cell adhesion molecule-like
OR6A2 olfactory receptor, family 6, subfamily A, member 2
PCBP2 poly(rC) binding protein 2
PDCD2 programmed cell death 2
PLA2G10 phospholipase A2, group X
PLA2G12A phospholipase A2, group XIIA
PLAUR plasminogen activator, urokinase receptor
POMT1 protein-O-mannosyltransferase 1
PPP1R17 protein phosphatase 1, regulatory subunit 17
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PTPRN protein tyrosine phosphatase, receptor type, N
PVR poliovirus receptor
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RAP1A RAP1A, member of RAS oncogene family
RBFA ribosome binding factor A (putative)
RBL2 retinoblastoma-like 2
RBM5 RNA binding motif protein 5
RFTN1 raftlin, lipid raft linker 1
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RPL7 ribosomal protein L7
SEZ6L seizure related 6 homolog (mouse)-like
SIRT3 sirtuin 3
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPK3 SRSF protein kinase 3
STK19 serine/threonine kinase 19
TCP11L1 t-complex 11, testis-specific-like 1
TMPRSS6 transmembrane protease, serine 6
TP53I11 tumor protein p53 inducible protein 11
TRIM33 tripartite motif containing 33
TRIO trio Rho guanine nucleotide exchange factor
TSPAN3 tetraspanin 3
TTC39A tetratricopeptide repeat domain 39A
TTI1 TELO2 interacting protein 1
UBL3 ubiquitin-like 3
ULK1 unc-51 like autophagy activating kinase 1
UNC93B1 unc-93 homolog B1 (C. elegans)
WDR77 WD repeat domain 77
WRAP73 WD repeat containing, antisense to TP73

decreased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMN amnion associated transmembrane protein
AMPH amphiphysin
ATG14 autophagy related 14
ATXN2 ataxin 2
BEGAIN brain-enriched guanylate kinase-associated
C12ORF43 chromosome 12 open reading frame 43
C7ORF43 chromosome 7 open reading frame 43
CAV3 caveolin 3
CCDC94 coiled-coil domain containing 94
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CPTP ceramide-1-phosphate transfer protein
CTF1 cardiotrophin 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYSLTR2 cysteinyl leukotriene receptor 2
DBF4B DBF4 zinc finger B
DOK3 docking protein 3
DSCAM Down syndrome cell adhesion molecule
EFCAB1 EF-hand calcium binding domain 1
EVPL envoplakin
GALK1 galactokinase 1
GMPR guanosine monophosphate reductase
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
HDC histidine decarboxylase
IL13 interleukin 13
IL36RN interleukin 36 receptor antagonist
IQCA1 IQ motif containing with AAA domain 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITPKB inositol-trisphosphate 3-kinase B
JMJD4 jumonji domain containing 4
KLHL36 kelch-like family member 36
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KREMEN2 kringle containing transmembrane protein 2
L2HGDH L-2-hydroxyglutarate dehydrogenase
LENEP lens epithelial protein
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LOC440895 two pore channel 3 pseudogene
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAL mal, T-cell differentiation protein
MARC1 mitochondrial amidoxime reducing component 1
MFGE8 milk fat globule-EGF factor 8 protein
MFSD12 major facilitator superfamily domain containing 12
MOXD1 monooxygenase, DBH-like 1
MTERF4 mitochondrial transcription termination factor 4
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYOZ1 myozenin 1
NARF nuclear prelamin A recognition factor
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NES nestin
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
ONECUT2 one cut homeobox 2
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PADI1 peptidyl arginine deiminase, type I
PARP8 poly (ADP-ribose) polymerase family, member 8
PAX1 paired box 1
PCDHB12 protocadherin beta 12
PCDHB3 protocadherin beta 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PECR peroxisomal trans-2-enoyl-CoA reductase
PEG3 paternally expressed 3
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
PLA2G15 phospholipase A2, group XV
PLXNB3 plexin B3
POGLUT1 protein O-glucosyltransferase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAME preferentially expressed antigen in melanoma
PRDM14 PR domain containing 14
PRG3 proteoglycan 3
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
PTPN7 protein tyrosine phosphatase, non-receptor type 7
RGSL1 regulator of G-protein signaling like 1
S100A1 S100 calcium binding protein A1
S100A2 S100 calcium binding protein A2
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH3BP1 SH3-domain binding protein 1
SLPI secretory leukocyte peptidase inhibitor
SPAG4 sperm associated antigen 4
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TMEM180 transmembrane protein 180
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
WNT3 wingless-type MMTV integration site family, member 3
ZFP36 ZFP36 ring finger protein
ZNF276 zinc finger protein 276
ZNF408 zinc finger protein 408
ZNF668 zinc finger protein 668
ZNF74 zinc finger protein 74
ZNRF4 zinc and ring finger 4