tetracaine-7473 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the tetracaine-7473 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFF2 AF4/FMR2 family, member 2
AIM1L absent in melanoma 1-like
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APOC1 apolipoprotein C-I
AR androgen receptor
ARHGAP44 Rho GTPase activating protein 44
ARTN artemin
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
BICD1 bicaudal D homolog 1 (Drosophila)
BTG2 BTG family, member 2
CD83 CD83 molecule
CDK12 cyclin-dependent kinase 12
CLCA1 chloride channel accessory 1
CTAGE5 CTAGE family, member 5
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCT dopachrome tautomerase
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DPF2 D4, zinc and double PHD fingers family 2
DST dystonin
EBF2 early B-cell factor 2
EFNB3 ephrin-B3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGF13 fibroblast growth factor 13
FGFR4 fibroblast growth factor receptor 4
FGL1 fibrinogen-like 1
FLJ21369 uncharacterized protein FLJ21369
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GIPR gastric inhibitory polypeptide receptor
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HFE hemochromatosis
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
ICOSLG inducible T-cell co-stimulator ligand
IFNA14 interferon, alpha 14
IL6R interleukin 6 receptor
INHBC inhibin, beta C
KCTD2 potassium channel tetramerization domain containing 2
KRT8 keratin 8, type II
LEPROT leptin receptor overlapping transcript
LYRM9 LYR motif containing 9
MAPK10 mitogen-activated protein kinase 10
MARK4 MAP/microtubule affinity-regulating kinase 4
MASP2 mannan-binding lectin serine peptidase 2
MAST3 microtubule associated serine/threonine kinase 3
MBOAT7 membrane bound O-acyltransferase domain containing 7
MEF2D myocyte enhancer factor 2D
MID1 midline 1
MIIP migration and invasion inhibitory protein
MXD4 MAX dimerization protein 4
MYL5 myosin, light chain 5, regulatory
NAAA N-acylethanolamine acid amidase
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOX1 NADPH oxidase 1
NREP neuronal regeneration related protein
NRSN2 neurensin 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OASL 2'-5'-oligoadenylate synthetase-like
PALM paralemmin
PAX5 paired box 5
PCDHA6 protocadherin alpha 6
PCDHA9 protocadherin alpha 9
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PLCH1 phospholipase C, eta 1
PLTP phospholipid transfer protein
PODNL1 podocan-like 1
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PXDC1 PX domain containing 1
RECQL5 RecQ protein-like 5
RPH3A rabphilin 3A
RREB1 ras responsive element binding protein 1
RSG1 REM2 and RAB-like small GTPase 1
SCARA3 scavenger receptor class A, member 3
SLAMF7 SLAM family member 7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SPRR1A small proline-rich protein 1A
SUGP1 SURP and G patch domain containing 1
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TM4SF5 transmembrane 4 L six family member 5
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TP53I11 tumor protein p53 inducible protein 11
TTC38 tetratricopeptide repeat domain 38
TTC9 tetratricopeptide repeat domain 9
USP2 ubiquitin specific peptidase 2
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZBTB48 zinc finger and BTB domain containing 48
ZBTB7A zinc finger and BTB domain containing 7A
ZC3H7B zinc finger CCCH-type containing 7B
ZFX zinc finger protein, X-linked
ZNF747 zinc finger protein 747
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ACTN4 actinin, alpha 4
ADCY6 adenylate cyclase 6
ADGRE5 adhesion G protein-coupled receptor E5
ATAD5 ATPase family, AAA domain containing 5
ATP7B ATPase, Cu++ transporting, beta polypeptide
BAGE B melanoma antigen
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BPGM 2,3-bisphosphoglycerate mutase
C16ORF59 chromosome 16 open reading frame 59
C19ORF40 chromosome 19 open reading frame 40
C1ORF35 chromosome 1 open reading frame 35
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative)
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK3 cyclin-dependent kinase 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CORO2A coronin, actin binding protein, 2A
CRYL1 crystallin, lambda 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DIXDC1 DIX domain containing 1
DOCK1 dedicator of cytokinesis 1
EAF2 ELL associated factor 2
EVPL envoplakin
FANCC Fanconi anemia, complementation group C
FKBP5 FK506 binding protein 5
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FUZ fuzzy planar cell polarity protein
GAB2 GRB2-associated binding protein 2
GALT galactose-1-phosphate uridylyltransferase
GLCE glucuronic acid epimerase
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR27 G protein-coupled receptor 27
HDAC11 histone deacetylase 11
HIST1H2BH histone cluster 1, H2bh
HIST1H4F histone cluster 1, H4f
HOXA5 homeobox A5
HP1BP3 heterochromatin protein 1, binding protein 3
HTRA1 HtrA serine peptidase 1
IP6K2 inositol hexakisphosphate kinase 2
IRF7 interferon regulatory factor 7
KLHL36 kelch-like family member 36
KRT13 keratin 13, type I
LAMB2 laminin, beta 2 (laminin S)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHX1 LIM homeobox 1
LMCD1 LIM and cysteine-rich domains 1
LMNB2 lamin B2
LOC642236 FSHD region gene 1 pseudogene
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LZTFL1 leucine zipper transcription factor-like 1
MB myoglobin
MCOLN3 mucolipin 3
NBEAL2 neurobeachin-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NLRX1 NLR family member X1
NT5DC3 5'-nucleotidase domain containing 3
ORAI3 ORAI calcium release-activated calcium modulator 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCDHB3 protocadherin beta 3
PEX26 peroxisomal biogenesis factor 26
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRICKLE3 prickle homolog 3 (Drosophila)
PROCR protein C receptor, endothelial
PRSS22 protease, serine, 22
PTCD2 pentatricopeptide repeat domain 2
PTTG3P pituitary tumor-transforming 3, pseudogene
RECQL4 RecQ protein-like 4
RFTN1 raftlin, lipid raft linker 1
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SIDT1 SID1 transmembrane family, member 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
STAG3L1 stromal antigen 3-like 1 (pseudogene)
THRAP3 thyroid hormone receptor associated protein 3
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM254 transmembrane protein 254
TMPRSS3 transmembrane protease, serine 3
TMPRSS4 transmembrane protease, serine 4
TRABD TraB domain containing
TSPYL2 TSPY-like 2
TTC17 tetratricopeptide repeat domain 17
UBXN6 UBX domain protein 6
UFSP2 UFM1-specific peptidase 2
ULBP2 UL16 binding protein 2
USB1 U6 snRNA biogenesis 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF32 zinc finger protein 32
ZNF586 zinc finger protein 586
ZNF701 zinc finger protein 701
ZNF768 zinc finger protein 768