testicular cancer Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A male reproductive system cancer that is located_in the testicles. (Human Disease Ontology, DOID_2998)
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Genes

337 genes co-occuring with the disease testicular cancer in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
AFP alpha-fetoprotein 2.22125
INSL3 insulin-like 3 (Leydig cell) 1.6077
ATF7IP activating transcription factor 7 interacting protein 1.28086
FAM71F2 family with sequence similarity 71, member F2 1.23429
DMRT1 doublesex and mab-3 related transcription factor 1 1.22432
INHA inhibin, alpha 1.18841
ALPPL2 alkaline phosphatase, placental-like 2 1.17249
ALPP alkaline phosphatase, placental 1.17249
SPRY4 sprouty homolog 4 (Drosophila) 1.15709
ALPL alkaline phosphatase, liver/bone/kidney 1.1507
PNMA2 paraneoplastic Ma antigen 2 1.1473
KITLG KIT ligand 1.13924
DND1 DND microRNA-mediated repression inhibitor 1 1.13036
GGN gametogenetin 1.12614
AR androgen receptor 1.03198
C11ORF72 chromosome 11 open reading frame 72 1.00879
ZNF253 zinc finger protein 253 0.955779
SHBG sex hormone-binding globulin 0.915963
TP53 tumor protein p53 0.878605
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.842573
RXFP2 relaxin/insulin-like family peptide receptor 2 0.842573
BAK1 BCL2-antagonist/killer 1 0.841344
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.840525
ESR2 estrogen receptor 2 (ER beta) 0.805667
RNF4 ring finger protein 4 0.791311
CLSTN3 calsyntenin 3 0.778204
SCIN scinderin 0.763494
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 0.762678
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 0.760231
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.746798
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 0.742735
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 0.733811
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.729762
CSH2 chorionic somatomammotropin hormone 2 0.725311
KLK13 kallikrein-related peptidase 13 0.722886
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 0.707961
LHCGR luteinizing hormone/choriogonadotropin receptor 0.707961
NANOG Nanog homeobox 0.705547
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 0.703938
ODF3 outer dense fiber of sperm tails 3 0.699116
TSPY1 testis specific protein, Y-linked 1 0.697911
PRMT7 protein arginine methyltransferase 7 0.694301
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 0.692296
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.688692
SERINC1 serine incorporator 1 0.676308
SNX16 sorting nexin 16 0.670333
KLK5 kallikrein-related peptidase 5 0.669936
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.66596
INHBE inhibin, beta E 0.651298
ESR1 estrogen receptor 1 0.650508
TSPY10 testis specific protein, Y-linked 10 0.650113
TSPY3 testis specific protein, Y-linked 3 0.650113
MAGEA4 melanoma antigen family A4 0.649323
NSUN5 NOP2/Sun domain family, member 5 0.638676
CUZD1 CUB and zona pellucida-like domains 1 0.624927
KLK3 kallikrein-related peptidase 3 0.624535
SERINC2 serine incorporator 2 0.6214
CHD2 chromodomain helicase DNA binding protein 2 0.619051
HSFY2 heat shock transcription factor, Y linked 2 0.60264
HSFY1 heat shock transcription factor, Y-linked 1 0.60264
BCL6 B-cell CLL/lymphoma 6 0.589001
HJURP Holliday junction recognition protein 0.587833
TEX101 testis expressed 101 0.581996
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.577716
GFRA1 GDNF family receptor alpha 1 0.57305
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 0.572662
AMH anti-Mullerian hormone 0.564889
STARD7 StAR-related lipid transfer (START) domain containing 7 0.564889
STK17A serine/threonine kinase 17a 0.557897
FGF4 fibroblast growth factor 4 0.556732
INHBC inhibin, beta C 0.555568
PODXL podocalyxin-like 0.549747
CD34 CD34 molecule 0.545481
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 0.544318
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.528835
TDRD1 tudor domain containing 1 0.52729
PNMA1 paraneoplastic Ma antigen 1 0.526132
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.524974
RLN1 relaxin 1 0.523816
PIWIL4 piwi-like RNA-mediated gene silencing 4 0.515725
B2M beta-2-microglobulin 0.51188
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.509576
ZNF143 zinc finger protein 143 0.505739
C5ORF38 chromosome 5 open reading frame 38 0.503824
CORIN corin, serine peptidase 0.499614
TOMM34 translocase of outer mitochondrial membrane 34 0.495029
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 0.493885
EBF3 early B-cell factor 3 0.484364
POLL polymerase (DNA directed), lambda 0.481325
NOP2 NOP2 nucleolar protein 0.477909
WDR77 WD repeat domain 77 0.476393
PRDM14 PR domain containing 14 0.473361
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial 0.473361
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.473361
FOXL2 forkhead box L2 0.472604
WT1 Wilms tumor 1 0.471846
HOXB5 homeobox B5 0.469197
GSTP1 glutathione S-transferase pi 1 0.462016
PRSS21 protease, serine, 21 (testisin) 0.461261
MT1M metallothionein 1M 0.457864
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 0.45447
TSGA10 testis specific, 10 0.446558
STK17B serine/threonine kinase 17b 0.442042
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 0.44129
PSG9 pregnancy specific beta-1-glycoprotein 9 0.440914
EBF2 early B-cell factor 2 0.440538
LTK leukocyte receptor tyrosine kinase 0.436778
CDK10 cyclin-dependent kinase 10 0.425514
GDNF glial cell derived neurotrophic factor 0.42364
HIST1H1D histone cluster 1, H1d 0.422515
MT1H metallothionein 1H 0.420266
ACPT acid phosphatase, testicular 0.419517
INHBB inhibin, beta B 0.416521
DNM3 dynamin 3 0.415398
HSF4 heat shock transcription factor 4 0.415024
RBMY1A1 RNA binding motif protein, Y-linked, family 1, member A1 0.413153
NCAM1 neural cell adhesion molecule 1 0.412405
SNHG12 small nucleolar RNA host gene 12 0.410161
CDY1 chromodomain protein, Y-linked, 1 0.40904
DRD1 dopamine receptor D1 0.402318
ENO2 enolase 2 (gamma, neuronal) 0.396353
HPGDS hematopoietic prostaglandin D synthase 0.396353
FGF9 fibroblast growth factor 9 0.39598
SOX9 SRY (sex determining region Y)-box 9 0.394863
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.390025
TGFB1 transforming growth factor, beta 1 0.388538
FST follistatin 0.388166
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.379997
STRA8 stimulated by retinoic acid 8 0.37555
HOXB6 homeobox B6 0.374438
GATA4 GATA binding protein 4 0.374438
NAAA N-acylethanolamine acid amidase 0.372217
CLTB clathrin, light chain B 0.372217
CLPTM1L CLPTM1-like 0.369258
PDE11A phosphodiesterase 11A 0.365932
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 0.365193
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.363347
CREB3L4 cAMP responsive element binding protein 3-like 4 0.359657
IGFALS insulin-like growth factor binding protein, acid labile subunit 0.355604
FOXA3 forkhead box A3 0.354131
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.345308
KLK1 kallikrein 1 0.344574
SMAD9 SMAD family member 9 0.342739
POU5F1 POU class 5 homeobox 1 0.341639
PIAS2 protein inhibitor of activated STAT, 2 0.33944
HOXA10 homeobox A10 0.338707
CALB2 calbindin 2 0.338707
DPYSL5 dihydropyrimidinase-like 5 0.336876
ACPP acid phosphatase, prostate 0.335778
PDGFB platelet-derived growth factor beta polypeptide 0.335412
PIWIL2 piwi-like RNA-mediated gene silencing 2 0.335412
FBXO44 F-box protein 44 0.333949
NODAL nodal growth differentiation factor 0.331025
YBX3 Y box binding protein 3 0.330295
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.321909
ZNF135 zinc finger protein 135 0.320454
CCND2 cyclin D2 0.318635
RNF43 ring finger protein 43 0.307395
PGR progesterone receptor 0.305948
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.305587
MVP major vault protein 0.304503
CDY1B chromodomain protein, Y-linked, 1B 0.300533
SCGB3A1 secretoglobin, family 3A, member 1 0.300173
MT1X metallothionein 1X 0.295492
SPATA21 spermatogenesis associated 21 0.289744
UVRAG UV radiation resistance associated 0.289027
LRRC4C leucine rich repeat containing 4C 0.28831
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.278654
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.27794
LDHB lactate dehydrogenase B 0.276158
TRIM27 tripartite motif containing 27 0.276158
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.275445
TERT telomerase reverse transcriptase 0.275089
KRT18 keratin 18, type I 0.274732
KLK14 kallikrein-related peptidase 14 0.272597
DAP death-associated protein 0.27153
FASLG Fas ligand (TNF superfamily, member 6) 0.271174
SLC35E2B solute carrier family 35, member E2B 0.270464
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.270464
AHRR aryl-hydrocarbon receptor repressor 0.269753
STK11 serine/threonine kinase 11 0.268687
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 0.26266
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.25877
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.257358
NARS asparaginyl-tRNA synthetase 0.255946
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.254888
CLDN6 claudin 6 0.253831
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.25207
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.250663
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.250663
DNTT DNA nucleotidylexotransferase 0.241546
PRM1 protamine 1 0.238403
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.237357
LCK LCK proto-oncogene, Src family tyrosine kinase 0.23666
AMHR2 anti-Mullerian hormone receptor, type II 0.233878
GDF6 growth differentiation factor 6 0.233878
FZD6 frizzled class receptor 6 0.23353
NRG3 neuregulin 3 0.233183
GJA1 gap junction protein, alpha 1, 43kDa 0.231795
GSTA3 glutathione S-transferase alpha 3 0.230409
GSTA2 glutathione S-transferase alpha 2 0.229024
PTPRC protein tyrosine phosphatase, receptor type, C 0.228333
GSTA4 glutathione S-transferase alpha 4 0.227988
BLMH bleomycin hydrolase 0.226262
IGFBP3 insulin-like growth factor binding protein 3 0.225573
EPHB6 EPH receptor B6 0.225573
SPA17 sperm autoantigenic protein 17 0.223853
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.223509
GSTA1 glutathione S-transferase alpha 1 0.222822
FZD2 frizzled class receptor 2 0.222822
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.222479
MELK maternal embryonic leucine zipper kinase 0.222479
ZFPM2 zinc finger protein, FOG family member 2 0.222136
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.221793
HOXA13 homeobox A13 0.22145
DAZL deleted in azoospermia-like 0.220081
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.219398
INHBA inhibin, beta A 0.217352
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 0.216332
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.215653
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.209583
FRMD6 FERM domain containing 6 0.208245
TET1 tet methylcytosine dioxygenase 1 0.207578
CCNA2 cyclin A2 0.203933
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.200982
CDC37 cell division cycle 37 0.200331
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.199033
IFNA21 interferon, alpha 21 0.199033
AMD1 adenosylmethionine decarboxylase 1 0.197099
ALB albumin 0.196459
SOX15 SRY (sex determining region Y)-box 15 0.19582
PIAS1 protein inhibitor of activated STAT, 1 0.194548
ATAD2 ATPase family, AAA domain containing 2 0.194232
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.192031
SLURP1 secreted LY6/PLAUR domain containing 1 0.191097
PRSS8 protease, serine, 8 0.190786
PRKCD protein kinase C, delta 0.190476
CTSA cathepsin A 0.190476
INS insulin 0.189551
PTHLH parathyroid hormone-like hormone 0.188326
SELPLG selectin P ligand 0.187113
ACVR1B activin A receptor, type IB 0.18591
RGAG1 retrotransposon gag domain containing 1 0.185313
RBP2 retinol binding protein 2, cellular 0.18472
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 0.181798
IFNA17 interferon, alpha 17 0.181222
CD27 CD27 molecule 0.180652
GML glycosylphosphatidylinositol anchored molecule like 0.180367
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.17952
FSHR follicle stimulating hormone receptor 0.17952
RAB3D RAB3D, member RAS oncogene family 0.179239
LEMD3 LEM domain containing 3 0.178682
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.178126
VGF VGF nerve growth factor inducible 0.177851
HLA-G major histocompatibility complex, class I, G 0.1761
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.174881
PTEN phosphatase and tensin homolog 0.174617
F2 coagulation factor II (thrombin) 0.173057
SMC3 structural maintenance of chromosomes 3 0.172291
GSTM1 glutathione S-transferase mu 1 0.170054
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.168854
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.167682
ERCC2 excision repair cross-complementation group 2 0.166319
ERCC1 excision repair cross-complementation group 1 0.164786
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.163893
CTAG2 cancer/testis antigen 2 0.163523
ADD2 adducin 2 (beta) 0.163111
CD200R1 CD200 receptor 1 0.162505
FZD7 frizzled class receptor 7 0.161331
BAX BCL2-associated X protein 0.160574
PCNA proliferating cell nuclear antigen 0.160203
RHOA ras homolog family member A 0.158266
POLG polymerase (DNA directed), gamma 0.158266
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.157929
KRT7 keratin 7, type II 0.14663
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.144343
SP3 Sp3 transcription factor 0.144213
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 0.144165
UPK3A uroplakin 3A 0.144151
SFN stratifin 0.143111
HPX hemopexin 0.142217
RUNX3 runt-related transcription factor 3 0.141657
GPC3 glypican 3 0.140556
SP1 Sp1 transcription factor 0.140012
APC adenomatous polyposis coli 0.139761
GSTM2 glutathione S-transferase mu 2 (muscle) 0.13668
PIDD1 p53-induced death domain protein 1 0.135399
AHSG alpha-2-HS-glycoprotein 0.135277
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.134999
TF transferrin 0.131818
PREB prolactin regulatory element binding 0.130297
HN1 hematological and neurological expressed 1 0.126612
TJP1 tight junction protein 1 0.124998
CD9 CD9 molecule 0.119687
POLK polymerase (DNA directed) kappa 0.119318
CCR3 chemokine (C-C motif) receptor 3 0.117685
BCL2 B-cell CLL/lymphoma 2 0.113807
MAGEA1 melanoma antigen family A1 0.112725
FOXP1 forkhead box P1 0.1117
KRT20 keratin 20, type I 0.110463
STAT1 signal transducer and activator of transcription 1, 91kDa 0.110043
BCL10 B-cell CLL/lymphoma 10 0.108023
RARB retinoic acid receptor, beta 0.107372
TGFBR3 transforming growth factor, beta receptor III 0.106982
MALT1 MALT1 paracaspase 0.106292
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.102196
LST1 leukocyte specific transcript 1 0.101359
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.101084
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.100933
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.099561
MYB v-myb avian myeloblastosis viral oncogene homolog 0.099304
EBF1 early B-cell factor 1 0.098995
FOS FBJ murine osteosarcoma viral oncogene homolog 0.098943
GATA6 GATA binding protein 6 0.096556
GP2 glycoprotein 2 (zymogen granule membrane) 0.095437
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.094889
GPER1 G protein-coupled estrogen receptor 1 0.092634
AHR aryl hydrocarbon receptor 0.091947
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.089665
GFAP glial fibrillary acidic protein 0.088022
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.085455
RLN2 relaxin 2 0.085022
PER3 period circadian clock 3 0.083898
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.083491
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.082797
HP haptoglobin 0.082733
HPR haptoglobin-related protein 0.082226
CD79A CD79a molecule, immunoglobulin-associated alpha 0.081302
PLAU plasminogen activator, urokinase 0.079629
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.079597
RXFP1 relaxin/insulin-like family peptide receptor 1 0.077873
TTR transthyretin 0.077415
APOA1 apolipoprotein A-I 0.075439
BMP7 bone morphogenetic protein 7 0.075406
B3GAT1 beta-1,3-glucuronyltransferase 1 0.07534
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.075174
CD44 CD44 molecule (Indian blood group) 0.073141