testicular atrophy Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Wasting (atrophy) of the testicle (the male gonad) manifested by a decrease in size and potentially by a loss of fertility. (Human Phenotype Ontology, HP_0000029)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003205
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Genes

46 gene mutations causing the testicular atrophy phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGTPBP1 ATP/GTP binding protein 1
AR androgen receptor
BMP8B bone morphogenetic protein 8b
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough
CCNE2 cyclin E2
CDK2 cyclin-dependent kinase 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CKS2 CDC28 protein kinase regulatory subunit 2
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DHCR24 24-dehydrocholesterol reductase
E2F1 E2F transcription factor 1
FANCC Fanconi anemia, complementation group C
GTF2I general transcription factor IIi
HELQ helicase, POLQ-like
HIP1 huntingtin interacting protein 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IP6K1 inositol hexakisphosphate kinase 1
KIF18A kinesin family member 18A
KL klotho
LOC101929327
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
MCM8 minichromosome maintenance complex component 8
MCPH1 microcephalin 1
PAX8 paired box 8
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PEX7 peroxisomal biogenesis factor 7
PHF13 PHD finger protein 13
PIWIL2 piwi-like RNA-mediated gene silencing 2
POLG polymerase (DNA directed), gamma
PRDX4 peroxiredoxin 4
PROKR2 prokineticin receptor 2
PTDSS2 phosphatidylserine synthase 2
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
SLC26A4 solute carrier family 26 (anion exchanger), member 4
TDRKH tudor and KH domain containing
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
UBB ubiquitin B
UBR2 ubiquitin protein ligase E3 component n-recognin 2
WDR48 WD repeat domain 48
WWOX WW domain containing oxidoreductase
ZBTB16 zinc finger and BTB domain containing 16
ZC3HC1 zinc finger, C3HC-type containing 1
ZFP42 ZFP42 zinc finger protein