terfenadine-6823 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the terfenadine-6823 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARC activity-regulated cytoskeleton-associated protein
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
CCL27 chemokine (C-C motif) ligand 27
CCNG2 cyclin G2
CD83 CD83 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN1 claudin 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
ETV5 ets variant 5
FGF18 fibroblast growth factor 18
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1D histone cluster 1, H1d
HIST1H1T histone cluster 1, H1t
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HMOX1 heme oxygenase 1
HRK harakiri, BCL2 interacting protein
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LIN7A lin-7 homolog A (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSGIN1 oxidative stress induced growth inhibitor 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND1 Rho family GTPase 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
TBKBP1 TBK1 binding protein 1
TGIF1 TGFB-induced factor homeobox 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADGRA3 adhesion G protein-coupled receptor A3
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALG6 ALG6, alpha-1,3-glucosyltransferase
ANKFY1 ankyrin repeat and FYVE domain containing 1
B3GNT1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C14ORF132 chromosome 14 open reading frame 132
C19ORF73 chromosome 19 open reading frame 73
C6ORF47 chromosome 6 open reading frame 47
C9ORF40 chromosome 9 open reading frame 40
CCNE2 cyclin E2
CCP110 centriolar coiled coil protein 110kDa
CENPB centromere protein B, 80kDa
CFD complement factor D (adipsin)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CIDEB cell death-inducing DFFA-like effector b
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DGAT1 diacylglycerol O-acyltransferase 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNAL4 dynein, axonemal, light chain 4
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF5A2 eukaryotic translation initiation factor 5A2
ENDOD1 endonuclease domain containing 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FAM134B family with sequence similarity 134, member B
FBXW12 F-box and WD repeat domain containing 12
FHOD1 formin homology 2 domain containing 1
FOXI1 forkhead box I1
GAMT guanidinoacetate N-methyltransferase
GAS8 growth arrest-specific 8
GEMIN6 gem (nuclear organelle) associated protein 6
GUSBP3 glucuronidase, beta pseudogene 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFT140 intraflagellar transport 140
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IPP intracisternal A particle-promoted polypeptide
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCTD20 potassium channel tetramerization domain containing 20
KIAA0125 KIAA0125
KREMEN2 kringle containing transmembrane protein 2
LHX6 LIM homeobox 6
LMBR1L limb development membrane protein 1-like
LOC730101 uncharacterized LOC730101
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LYRM9 LYR motif containing 9
LZTR1 leucine-zipper-like transcription regulator 1
MAT2A methionine adenosyltransferase II, alpha
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NHLRC2 NHL repeat containing 2
NIPAL2 NIPA-like domain containing 2
NRSN2 neurensin 2
NTHL1 nth endonuclease III-like 1 (E. coli)
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHA6 protocadherin alpha 6
PGBD5 piggyBac transposable element derived 5
PHC1 polyhomeotic homolog 1 (Drosophila)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PROCR protein C receptor, endothelial
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPH3AL rabphilin 3A-like (without C2 domains)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
S100A9 S100 calcium binding protein A9
SAYSD1 SAYSVFN motif domain containing 1
SCAI suppressor of cancer cell invasion
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SOX3 SRY (sex determining region Y)-box 3
STX17 syntaxin 17
TAOK1 TAO kinase 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TRIM21 tripartite motif containing 21
TRIM66 tripartite motif containing 66
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
WDR76 WD repeat domain 76
ZNF227 zinc finger protein 227
ZNF324 zinc finger protein 324
ZNF492 zinc finger protein 492
ZNF573 zinc finger protein 573
ZNF74 zinc finger protein 74
ZSCAN26 zinc finger and SCAN domain containing 26