terfenadine-2227 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the terfenadine-2227 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALOX15B arachidonate 15-lipoxygenase, type B
ARC activity-regulated cytoskeleton-associated protein
ARL14 ADP-ribosylation factor-like 14
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BDKRB2 bradykinin receptor B2
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
C8ORF4 chromosome 8 open reading frame 4
CCNG2 cyclin G2
CEMIP cell migration inducing protein, hyaluronan binding
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN6 chloride channel, voltage-sensitive 6
CPEB1 cytoplasmic polyadenylation element binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR4 early growth response 4
FAM46C family with sequence similarity 46, member C
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H2BI histone cluster 1, H2bi
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H4H histone cluster 1, H4h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IER2 immediate early response 2
IL21R interleukin 21 receptor
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LOC157562 uncharacterized LOC157562
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK7 mitogen-activated protein kinase 7
MVD mevalonate (diphospho) decarboxylase
NF2 neurofibromin 2 (merlin)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RND1 Rho family GTPase 1
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
TEX14 testis expressed 14
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADTRP androgen-dependent TFPI-regulating protein
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ASAP1-IT1 ASAP1 intronic transcript 1
ATAT1 alpha tubulin acetyltransferase 1
BACE1 beta-site APP-cleaving enzyme 1
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C11ORF30 chromosome 11 open reading frame 30
C1ORF105 chromosome 1 open reading frame 105
C2ORF27A chromosome 2 open reading frame 27A
C5AR2 complement component 5a receptor 2
C9ORF9 chromosome 9 open reading frame 9
CA2 carbonic anhydrase II
CAMK1 calcium/calmodulin-dependent protein kinase I
CCNE2 cyclin E2
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDON cell adhesion associated, oncogene regulated
CHST10 carbohydrate sulfotransferase 10
CORT cortistatin
CPPED1 calcineurin-like phosphoesterase domain containing 1
CROT carnitine O-octanoyltransferase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DSPP dentin sialophosphoprotein
DTX2 deltex 2, E3 ubiquitin ligase
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ETAA1 Ewing tumor-associated antigen 1
FER fer (fps/fes related) tyrosine kinase
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GDAP1 ganglioside induced differentiation associated protein 1
GPR27 G protein-coupled receptor 27
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HELLS helicase, lymphoid-specific
HIST1H1D histone cluster 1, H1d
HOXA4 homeobox A4
IL17RA interleukin 17 receptor A
IPO8 importin 8
IPP intracisternal A particle-promoted polypeptide
KIF3A kinesin family member 3A
L2HGDH L-2-hydroxyglutarate dehydrogenase
LOC257152 uncharacterized LOC257152
LRRC37A2 leucine rich repeat containing 37, member A2
MANEA mannosidase, endo-alpha
MBTD1 mbt domain containing 1
METTL8 methyltransferase like 8
MGC12488
MIS18BP1 MIS18 binding protein 1
MPHOSPH8 M-phase phosphoprotein 8
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MSMB microseminoprotein, beta-
NIPAL2 NIPA-like domain containing 2
NPTX1 neuronal pentraxin I
NUP62CL nucleoporin 62kDa C-terminal like
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OSMR oncostatin M receptor
PHEX phosphate regulating endopeptidase homolog, X-linked
POLL polymerase (DNA directed), lambda
PROS1 protein S (alpha)
PRR14L proline rich 14-like
PRR15L proline rich 15-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB30 RAB30, member RAS oncogene family
RANBP6 RAN binding protein 6
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SAYSD1 SAYSVFN motif domain containing 1
SIPA1 signal-induced proliferation-associated 1
SLC16A6 solute carrier family 16, member 6
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SRD5A3 steroid 5 alpha-reductase 3
STAB2 stabilin 2
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STARD3 StAR-related lipid transfer (START) domain containing 3
STIM1 stromal interaction molecule 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TDRD1 tudor domain containing 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WDR3 WD repeat domain 3
WDR91 WD repeat domain 91
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XYLT2 xylosyltransferase II
ZBTB6 zinc finger and BTB domain containing 6
ZIC3 Zic family member 3
ZNF37BP zinc finger protein 37B, pseudogene
ZNF480 zinc finger protein 480
ZNF74 zinc finger protein 74
ZNF770 zinc finger protein 770