terazosin-7187 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the terazosin-7187 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABHD6 abhydrolase domain containing 6
ADAM17 ADAM metallopeptidase domain 17
ADCY9 adenylate cyclase 9
ADGRA2 adhesion G protein-coupled receptor A2
AK2 adenylate kinase 2
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C4 aldo-keto reductase family 1, member C4
ANKRD6 ankyrin repeat domain 6
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ASIC1 acid sensing (proton gated) ion channel 1
ATP11A ATPase, class VI, type 11A
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
CC2D1A coiled-coil and C2 domain containing 1A
CCNO cyclin O
CD7 CD7 molecule
CDC73 cell division cycle 73
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDND1 claudin domain containing 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CST4 cystatin S
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DTNA dystrobrevin, alpha
EHBP1L1 EH domain binding protein 1-like 1
EXOC5 exocyst complex component 5
FAM169A family with sequence similarity 169, member A
FBXO22 F-box protein 22
FGD1 FYVE, RhoGEF and PH domain containing 1
FILIP1L filamin A interacting protein 1-like
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAMT guanidinoacetate N-methyltransferase
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GM2A GM2 ganglioside activator
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H1E histone cluster 1, H1e
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPG2 heparan sulfate proteoglycan 2
IGHM immunoglobulin heavy constant mu
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSIG1 insulin induced gene 1
ITGA10 integrin, alpha 10
KIAA0930 KIAA0930
LYPD1 LY6/PLAUR domain containing 1
LZTFL1 leucine zipper transcription factor-like 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK11 mitogen-activated protein kinase 11
MAPK13 mitogen-activated protein kinase 13
MAPK7 mitogen-activated protein kinase 7
MBNL2 muscleblind-like splicing regulator 2
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MTMR3 myotubularin related protein 3
MVD mevalonate (diphospho) decarboxylase
MVK mevalonate kinase
NF2 neurofibromin 2 (merlin)
NOP16 NOP16 nucleolar protein
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDGFB platelet-derived growth factor beta polypeptide
PEX7 peroxisomal biogenesis factor 7
PLK4 polo-like kinase 4
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PRKCA protein kinase C, alpha
PRKD3 protein kinase D3
PTBP3 polypyrimidine tract binding protein 3
RAB11B RAB11B, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
RNASEH2B ribonuclease H2, subunit B
RNF6 ring finger protein (C3H2C3 type) 6
RNGTT RNA guanylyltransferase and 5'-phosphatase
RNMT RNA (guanine-7-) methyltransferase
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC24D SEC24 family member D
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMR3A submaxillary gland androgen regulated protein 3A
SOD2 superoxide dismutase 2, mitochondrial
SPAG8 sperm associated antigen 8
SS18 synovial sarcoma translocation, chromosome 18
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STOML1 stomatin (EPB72)-like 1
SYBU syntabulin (syntaxin-interacting)
SYNC syncoilin, intermediate filament protein
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TBC1D17 TBC1 domain family, member 17
TPD52 tumor protein D52
TTC28 tetratricopeptide repeat domain 28
TTC33 tetratricopeptide repeat domain 33
ZBTB14 zinc finger and BTB domain containing 14
ZFHX2 zinc finger homeobox 2
ZFYVE9 zinc finger, FYVE domain containing 9
ZMAT5 zinc finger, matrin-type 5
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCORL1 BCL6 corepressor-like 1
C1ORF115 chromosome 1 open reading frame 115
C21ORF91 chromosome 21 open reading frame 91
C7ORF43 chromosome 7 open reading frame 43
CD82 CD82 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNGB3 cyclic nucleotide gated channel beta 3
CORO2A coronin, actin binding protein, 2A
CTC1 CTS telomere maintenance complex component 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DGAT1 diacylglycerol O-acyltransferase 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ELMO3 engulfment and cell motility 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERN2 endoplasmic reticulum to nucleus signaling 2
ETAA1 Ewing tumor-associated antigen 1
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FZD4 frizzled class receptor 4
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLI3 GLI family zinc finger 3
GMPPA GDP-mannose pyrophosphorylase A
GPATCH3 G patch domain containing 3
HIST1H2AI histone cluster 1, H2ai
HIST1H2BO histone cluster 1, H2bo
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IRF1 interferon regulatory factor 1
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHX1 LIM homeobox 1
LMBR1L limb development membrane protein 1-like
MAP9 microtubule-associated protein 9
MATK megakaryocyte-associated tyrosine kinase
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
METTL8 methyltransferase like 8
MFSD12 major facilitator superfamily domain containing 12
MMP9 matrix metallopeptidase 9
MOSPD3 motile sperm domain containing 3
NES nestin
NPM3 nucleophosmin/nucleoplasmin 3
OLFML3 olfactomedin-like 3
OTUD3 OTU deubiquitinase 3
PCDHB3 protocadherin beta 3
PDE12 phosphodiesterase 12
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G15 phospholipase A2, group XV
PLEC plectin
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PYGB phosphorylase, glycogen; brain
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RBL1 retinoblastoma-like 1
RCOR3 REST corepressor 3
RNF31 ring finger protein 31
SALL2 spalt-like transcription factor 2
SCD5 stearoyl-CoA desaturase 5
SCHIP1 schwannomin interacting protein 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SH2D4A SH2 domain containing 4A
SIRT6 sirtuin 6
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A14 solute carrier family 22, member 14
SMA4 glucuronidase, beta pseudogene
SNAI2 snail family zinc finger 2
SPAG4 sperm associated antigen 4
SPATA7 spermatogenesis associated 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TDRD1 tudor domain containing 1
THBS3 thrombospondin 3
TLR5 toll-like receptor 5
TMEM104 transmembrane protein 104
TMUB2 transmembrane and ubiquitin-like domain containing 2
TOM1 target of myb1 (chicken)
TPST2 tyrosylprotein sulfotransferase 2
TRAF2 TNF receptor-associated factor 2
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
UBXN6 UBX domain protein 6
USB1 U6 snRNA biogenesis 1
VASH1 vasohibin 1
VEGFC vascular endothelial growth factor C
ZBTB39 zinc finger and BTB domain containing 39
ZBTB40 zinc finger and BTB domain containing 40
ZC3H12A zinc finger CCCH-type containing 12A
ZNF205 zinc finger protein 205
ZNF574 zinc finger protein 574
ZXDC ZXD family zinc finger C