tanespimycin-998 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the tanespimycin-998 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCY7 adenylate cyclase 7
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ATP11A ATPase, class VI, type 11A
BAG2 BCL2-associated athanogene 2
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BIN1 bridging integrator 1
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BTN2A2 butyrophilin, subfamily 2, member A2
CCDC186 coiled-coil domain containing 186
CCDC81 coiled-coil domain containing 81
CCNG2 cyclin G2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRELD1 cysteine-rich with EGF-like domains 1
CSRP2 cysteine and glycine-rich protein 2
DAGLA diacylglycerol lipase, alpha
DBF4B DBF4 zinc finger B
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DST dystonin
ERN2 endoplasmic reticulum to nucleus signaling 2
EWSR1 EWS RNA-binding protein 1
FLJ21369 uncharacterized protein FLJ21369
GAS7 growth arrest-specific 7
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HFE hemochromatosis
HIST1H2AI histone cluster 1, H2ai
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA1L heat shock 70kDa protein 1-like
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB11 heat shock protein family B (small), member 11
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
ITGB5 integrin, beta 5
JAG1 jagged 1
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
LMAN1 lectin, mannose-binding, 1
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LZTFL1 leucine zipper transcription factor-like 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAP1L2 nucleosome assembly protein 1-like 2
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
POPDC3 popeye domain containing 3
PPID peptidylprolyl isomerase D
PRLR prolactin receptor
PRSS16 protease, serine, 16 (thymus)
RFPL2 ret finger protein-like 2
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RNASE4 ribonuclease, RNase A family, 4
ROM1 retinal outer segment membrane protein 1
RUNDC3B RUN domain containing 3B
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SNX29 sorting nexin 29
SYMPK symplekin
TES testin LIM domain protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPYL2 TSPY-like 2
VLDLR very low density lipoprotein receptor
WDR1 WD repeat domain 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZER1 zyg-11 related, cell cycle regulator
ZNF10 zinc finger protein 10
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNF235 zinc finger protein 235
ZNF329 zinc finger protein 329
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACVR2B activin A receptor, type IIB
AHR aryl hydrocarbon receptor
ARRB2 arrestin, beta 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BAMBI BMP and activin membrane-bound inhibitor
BLM Bloom syndrome, RecQ helicase-like
C11ORF95 chromosome 11 open reading frame 95
C16ORF59 chromosome 16 open reading frame 59
C9ORF3 chromosome 9 open reading frame 3
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNE1 cyclin E1
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF16 DDB1 and CUL4 associated factor 16
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
EGR3 early growth response 3
ESRP2 epithelial splicing regulatory protein 2
FBRS fibrosin
GCHFR GTP cyclohydrolase I feedback regulator
GLMN glomulin, FKBP associated protein
GPR19 G protein-coupled receptor 19
GPRC5C G protein-coupled receptor, class C, group 5, member C
HOXC13 homeobox C13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IFT81 intraflagellar transport 81
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRF7 interferon regulatory factor 7
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIN37 lin-37 DREAM MuvB core complex component
LINC00115 long intergenic non-protein coding RNA 115
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LY6G5C lymphocyte antigen 6 complex, locus G5C
METTL1 methyltransferase like 1
MOCS3 molybdenum cofactor synthesis 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARFL nuclear prelamin A recognition factor-like
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR1H3 nuclear receptor subfamily 1, group H, member 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PCF11 PCF11 cleavage and polyadenylation factor subunit
PCGF3 polycomb group ring finger 3
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEX26 peroxisomal biogenesis factor 26
PGP phosphoglycolate phosphatase
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
POLH polymerase (DNA directed), eta
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POLR1E polymerase (RNA) I polypeptide E, 53kDa
PRKCD protein kinase C, delta
PRMT7 protein arginine methyltransferase 7
PSKH1 protein serine kinase H1
PUS1 pseudouridylate synthase 1
PYCRL pyrroline-5-carboxylate reductase-like
RAB33B RAB33B, member RAS oncogene family
RBM14 RNA binding motif protein 14
REEP4 receptor accessory protein 4
RGS16 regulator of G-protein signaling 16
RIBC2 RIB43A domain with coiled-coils 2
RPAP1 RNA polymerase II associated protein 1
RPP25 ribonuclease P/MRP 25kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SETD6 SET domain containing 6
SETMAR SET domain and mariner transposase fusion gene
SH2B2 SH2B adaptor protein 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC2A4RG SLC2A4 regulator
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD7 SMAD family member 7
SPATA2L spermatogenesis associated 2-like
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D31 TBC1 domain family, member 31
THAP7 THAP domain containing 7
THOP1 thimet oligopeptidase 1
TMEM51 transmembrane protein 51
TRAF4 TNF receptor-associated factor 4
TRAPPC12 trafficking protein particle complex 12
ZNF276 zinc finger protein 276
ZNF354A zinc finger protein 354A
ZNF512B zinc finger protein 512B
ZNF552 zinc finger protein 552
ZNF721 zinc finger protein 721
ZXDC ZXD family zinc finger C