tanespimycin-986 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the tanespimycin-986 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY7 adenylate cyclase 7
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
ATXN3 ataxin 3
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BMP2K BMP2 inducible kinase
BTF3P12 basic transcription factor 3 pseudogene 12
C7ORF69 chromosome 7 open reading frame 69
CA11 carbonic anhydrase XI
CA4 carbonic anhydrase IV
CABIN1 calcineurin binding protein 1
CCNG2 cyclin G2
CD79B CD79b molecule, immunoglobulin-associated beta
CDH8 cadherin 8, type 2
CDK3 cyclin-dependent kinase 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL1A2 collagen, type I, alpha 2
CROCC ciliary rootlet coiled-coil, rootletin
CSRP2 cysteine and glycine-rich protein 2
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DBF4B DBF4 zinc finger B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSPP dentin sialophosphoprotein
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EMID1 EMI domain containing 1
ERP44 endoplasmic reticulum protein 44
FAM46C family with sequence similarity 46, member C
FHL1 four and a half LIM domains 1
GLP1R glucagon-like peptide 1 receptor
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GRM8 glutamate receptor, metabotropic 8
GSTA3 glutathione S-transferase alpha 3
HCRP1 hepatocellular carcinoma-related HCRP1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFIH1 interferon induced with helicase C domain 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
METTL5 methyltransferase like 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAP1L2 nucleosome assembly protein 1-like 2
NF2 neurofibromin 2 (merlin)
NRF1 nuclear respiratory factor 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAX8 paired box 8
PCDHA5 protocadherin alpha 5
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PLK4 polo-like kinase 4
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAPSN receptor-associated protein of the synapse
RBM5 RNA binding motif protein 5
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS12 regulator of G-protein signaling 12
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS3A ribosomal protein S3A
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SLAMF7 SLAM family member 7
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SOS2 son of sevenless homolog 2 (Drosophila)
SPRR1A small proline-rich protein 1A
SRD5A3 steroid 5 alpha-reductase 3
SSX1 synovial sarcoma, X breakpoint 1
STK17B serine/threonine kinase 17b
TES testin LIM domain protein
TIGD6 tigger transposable element derived 6
TMED7 transmembrane emp24 protein transport domain containing 7
TRIM2 tripartite motif containing 2
TSGA10 testis specific, 10
TSPYL2 TSPY-like 2
TSSK2 testis-specific serine kinase 2
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
ZNF165 zinc finger protein 165
ZNF222 zinc finger protein 222
ZNF227 zinc finger protein 227
ZNF350 zinc finger protein 350
ZNF419 zinc finger protein 419
ZNF571 zinc finger protein 571

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACKR3 atypical chemokine receptor 3
ADCK3 aarF domain containing kinase 3
ADCY6 adenylate cyclase 6
ADGRA3 adhesion G protein-coupled receptor A3
AEN apoptosis enhancing nuclease
ANKRD28 ankyrin repeat domain 28
ARRB2 arrestin, beta 2
BACE1 beta-site APP-cleaving enzyme 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BIK BCL2-interacting killer (apoptosis-inducing)
BTBD2 BTB (POZ) domain containing 2
C10ORF2 chromosome 10 open reading frame 2
C11ORF95 chromosome 11 open reading frame 95
CAMTA1 calmodulin binding transcription activator 1
CCDC15 coiled-coil domain containing 15
CCNE1 cyclin E1
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
CRYZL1 crystallin, zeta (quinone reductase)-like 1
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DNM1 dynamin 1
DNMBP dynamin binding protein
DSCAM Down syndrome cell adhesion molecule
E2F1 E2F transcription factor 1
ECHDC3 enoyl CoA hydratase domain containing 3
EFNA1 ephrin-A1
EGR3 early growth response 3
ESRP2 epithelial splicing regulatory protein 2
FAM63A family with sequence similarity 63, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FHOD1 formin homology 2 domain containing 1
FJX1 four jointed box 1 (Drosophila)
FOXC1 forkhead box C1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GJA1 gap junction protein, alpha 1, 43kDa
GNL1 guanine nucleotide binding protein-like 1
GPR19 G protein-coupled receptor 19
GRWD1 glutamate-rich WD repeat containing 1
H2AFY2 H2A histone family, member Y2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
INPP5F inositol polyphosphate-5-phosphatase F
IRAK4 interleukin-1 receptor-associated kinase 4
JADE1 jade family PHD finger 1
JUNB jun B proto-oncogene
KDM7A lysine (K)-specific demethylase 7A
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
LINC00115 long intergenic non-protein coding RNA 115
LMCD1 LIM and cysteine-rich domains 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRP3 low density lipoprotein receptor-related protein 3
LY6G5C lymphocyte antigen 6 complex, locus G5C
METTL8 methyltransferase like 8
MKNK1 MAP kinase interacting serine/threonine kinase 1
MNS1 meiosis-specific nuclear structural 1
MOAP1 modulator of apoptosis 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUPL2 nucleoporin like 2
ORAI3 ORAI calcium release-activated calcium modulator 3
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAQR6 progestin and adipoQ receptor family member VI
PCF11 PCF11 cleavage and polyadenylation factor subunit
PLD3 phospholipase D family, member 3
PMM1 phosphomannomutase 1
PRR7 proline rich 7 (synaptic)
PTCD2 pentatricopeptide repeat domain 2
RBM14 RNA binding motif protein 14
RBM38 RNA binding motif protein 38
RFTN1 raftlin, lipid raft linker 1
RGS16 regulator of G-protein signaling 16
RIC8B RIC8 guanine nucleotide exchange factor B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SKA1 spindle and kinetochore associated complex subunit 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SPATA2L spermatogenesis associated 2-like
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STBD1 starch binding domain 1
SYTL2 synaptotagmin-like 2
TEAD4 TEA domain family member 4
TELO2 telomere maintenance 2
TIPIN TIMELESS interacting protein
TMEM62 transmembrane protein 62
TRAPPC12 trafficking protein particle complex 12
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
ZBED1 zinc finger, BED-type containing 1
ZBTB24 zinc finger and BTB domain containing 24
ZXDC ZXD family zinc finger C