tanespimycin-947 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the tanespimycin-947 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ANXA1 annexin A1
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BMP1 bone morphogenetic protein 1
BMP4 bone morphogenetic protein 4
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CCNG2 cyclin G2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLK1 CDC-like kinase 1
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDRF1 erythroid differentiation regulatory factor 1
ERP44 endoplasmic reticulum protein 44
ETV5 ets variant 5
FASTKD2 FAST kinase domains 2
FCMR Fc fragment of IgM receptor
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP14 FK506 binding protein 14, 22 kDa
GON4L gon-4-like (C. elegans)
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HFE hemochromatosis
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA1L heat shock 70kDa protein 1-like
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
HYOU1 hypoxia up-regulated 1
INHBE inhibin, beta E
JAG1 jagged 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MED6 mediator complex subunit 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MORC4 MORC family CW-type zinc finger 4
MSL3 male-specific lethal 3 homolog (Drosophila)
NAIP NLR family, apoptosis inhibitory protein
NAP1L2 nucleosome assembly protein 1-like 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NGLY1 N-glycanase 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA4 protein disulfide isomerase family A, member 4
PGAP1 post-GPI attachment to proteins 1
PLA2G3 phospholipase A2, group III
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRSS16 protease, serine, 16 (thymus)
RAD52 RAD52 homolog (S. cerevisiae)
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS2 regulator of G-protein signaling 2
RHOQ ras homolog family member Q
RNASE4 ribonuclease, RNase A family, 4
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERBP1 SERPINE1 mRNA binding protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SP110 SP110 nuclear body protein
SSBP1 single-stranded DNA binding protein 1, mitochondrial
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TES testin LIM domain protein
TRIM2 tripartite motif containing 2
TSPYL2 TSPY-like 2
TUBA3D tubulin, alpha 3d
UBQLN4 ubiquilin 4
USP34 ubiquitin specific peptidase 34
VLDLR very low density lipoprotein receptor
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZMYND8 zinc finger, MYND-type containing 8
ZNF10 zinc finger protein 10
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNF329 zinc finger protein 329
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADGRL2 adhesion G protein-coupled receptor L2
AEN apoptosis enhancing nuclease
ANKRD36B ankyrin repeat domain 36B
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARL2 ADP-ribosylation factor-like 2
ARMC6 armadillo repeat containing 6
BIK BCL2-interacting killer (apoptosis-inducing)
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C10ORF88 chromosome 10 open reading frame 88
C22ORF29 chromosome 22 open reading frame 29
CCDC92 coiled-coil domain containing 92
CENPQ centromere protein Q
COA7 cytochrome c oxidase assembly factor 7 (putative)
CORO1A coronin, actin binding protein, 1A
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEAF1 DEAF1 transcription factor
DUSP8 dual specificity phosphatase 8
E4F1 E4F transcription factor 1
EFHD2 EF-hand domain family, member D2
EGLN1 egl-9 family hypoxia-inducible factor 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHA4 EPH receptor A4
EPN3 epsin 3
ERCC4 excision repair cross-complementation group 4
ESRP2 epithelial splicing regulatory protein 2
FA2H fatty acid 2-hydroxylase
FJX1 four jointed box 1 (Drosophila)
FMO4 flavin containing monooxygenase 4
FOXC1 forkhead box C1
HCFC2 host cell factor C2
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BI histone cluster 1, H2bi
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IFT22 intraflagellar transport 22
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRX4 iroquois homeobox 4
JUNB jun B proto-oncogene
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
LINC00115 long intergenic non-protein coding RNA 115
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC8E leucine rich repeat containing 8 family, member E
METTL4 methyltransferase like 4
MID1IP1 MID1 interacting protein 1
MNX1 motor neuron and pancreas homeobox 1
MOCS3 molybdenum cofactor synthesis 3
MT1H metallothionein 1H
NARFL nuclear prelamin A recognition factor-like
NCAM2 neural cell adhesion molecule 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPL2 nucleoporin like 2
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PCBP4 poly(rC) binding protein 4
PCF11 PCF11 cleavage and polyadenylation factor subunit
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PRKCD protein kinase C, delta
PRMT7 protein arginine methyltransferase 7
PRR15L proline rich 15-like
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS16 regulator of G-protein signaling 16
RGS19 regulator of G-protein signaling 19
RIBC2 RIB43A domain with coiled-coils 2
RIC8B RIC8 guanine nucleotide exchange factor B
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SCO2 SCO2 cytochrome c oxidase assembly protein
SH2B2 SH2B adaptor protein 2
SIDT1 SID1 transmembrane family, member 1
SLC16A6 solute carrier family 16, member 6
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMAD7 SMAD family member 7
SOBP sine oculis binding protein homolog (Drosophila)
TBCC tubulin folding cofactor C
TEX264 testis expressed 264
THOP1 thimet oligopeptidase 1
TMEM254 transmembrane protein 254
TPTE transmembrane phosphatase with tensin homology
TRAF4 TNF receptor-associated factor 4
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TULP4 tubby like protein 4
TXLNG taxilin gamma
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
WDR4 WD repeat domain 4
ZFC3H1 zinc finger, C3H1-type containing
ZNF124 zinc finger protein 124
ZXDC ZXD family zinc finger C