tanespimycin-916 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the tanespimycin-916 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ADCY7 adenylate cyclase 7
AKAP9 A kinase (PRKA) anchor protein 9
ARMCX4 armadillo repeat containing, X-linked 4
ATF2 activating transcription factor 2
BAG2 BCL2-associated athanogene 2
C1ORF54 chromosome 1 open reading frame 54
CACFD1 calcium channel flower domain containing 1
CCNG2 cyclin G2
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFLAR CASP8 and FADD-like apoptosis regulator
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLCN7 chloride channel, voltage-sensitive 7
COL1A1 collagen, type I, alpha 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRELD1 cysteine-rich with EGF-like domains 1
CSNK1G1 casein kinase 1, gamma 1
CSRP2 cysteine and glycine-rich protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
EDRF1 erythroid differentiation regulatory factor 1
ENGASE endo-beta-N-acetylglucosaminidase
FAM46C family with sequence similarity 46, member C
GEM GTP binding protein overexpressed in skeletal muscle
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HFE hemochromatosis
HIPK2 homeodomain interacting protein kinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA1L heat shock 70kDa protein 1-like
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAG1 jagged 1
KREMEN2 kringle containing transmembrane protein 2
LPIN1 lipin 1
LRRC40 leucine rich repeat containing 40
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OSBPL1A oxysterol binding protein-like 1A
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER1 period circadian clock 1
PLA2G3 phospholipase A2, group III
PPID peptidylprolyl isomerase D
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PROS1 protein S (alpha)
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
RCAN1 regulator of calcineurin 1
REPS1 RALBP1 associated Eps domain containing 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCAMP1 secretory carrier membrane protein 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNAI2 snail family zinc finger 2
SP100 SP100 nuclear antigen
STAT2 signal transducer and activator of transcription 2, 113kDa
SUGP1 SURP and G patch domain containing 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TES testin LIM domain protein
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TSPYL2 TSPY-like 2
USP34 ubiquitin specific peptidase 34
VLDLR very low density lipoprotein receptor
WIPF1 WAS/WASL interacting protein family, member 1
YIPF4 Yip1 domain family, member 4
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZMYND8 zinc finger, MYND-type containing 8
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNF419 zinc finger protein 419
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAM15 ADAM metallopeptidase domain 15
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD3A ATPase family, AAA domain containing 3A
ATF3 activating transcription factor 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C10ORF88 chromosome 10 open reading frame 88
CASKIN2 CASK interacting protein 2
CCDC85C coiled-coil domain containing 85C
CD3EAP CD3e molecule, epsilon associated protein
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPO centromere protein O
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CISH cytokine inducible SH2-containing protein
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DBR1 debranching RNA lariats 1
DCAF16 DDB1 and CUL4 associated factor 16
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
E2F8 E2F transcription factor 8
EFNA1 ephrin-A1
EGR3 early growth response 3
FAM160B2 family with sequence similarity 160, member B2
FAM65A family with sequence similarity 65, member A
FLT4 fms-related tyrosine kinase 4
FOXA1 forkhead box A1
GHR growth hormone receptor
GLCE glucuronic acid epimerase
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR19 G protein-coupled receptor 19
GRWD1 glutamate-rich WD repeat containing 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HILPDA hypoxia inducible lipid droplet-associated
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IRX5 iroquois homeobox 5
KIAA0319L KIAA0319-like
LMCD1 LIM and cysteine-rich domains 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MAD2L1BP MAD2L1 binding protein
MAST3 microtubule associated serine/threonine kinase 3
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MCM10 minichromosome maintenance complex component 10
METTL8 methyltransferase like 8
MID1IP1 MID1 interacting protein 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP9 matrix metallopeptidase 9
MTCL1 microtubule crosslinking factor 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYBBP1A MYB binding protein (P160) 1a
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PCDHB13 protocadherin beta 13
PRICKLE3 prickle homolog 3 (Drosophila)
PTDSS2 phosphatidylserine synthase 2
PUS1 pseudouridylate synthase 1
RBM14 RNA binding motif protein 14
REEP4 receptor accessory protein 4
RGS16 regulator of G-protein signaling 16
RIBC2 RIB43A domain with coiled-coils 2
RNF25 ring finger protein 25
RPL23AP7 ribosomal protein L23a pseudogene 7
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMD9 sterile alpha motif domain containing 9
SCN1B sodium channel, voltage gated, type I beta subunit
SETMAR SET domain and mariner transposase fusion gene
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD7 SMAD family member 7
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SNHG3 small nucleolar RNA host gene 3
SPATA2L spermatogenesis associated 2-like
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
TARP TCR gamma alternate reading frame protein
TEAD3 TEA domain family member 3
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THAP10 THAP domain containing 10
TICAM1 toll-like receptor adaptor molecule 1
TMEM51 transmembrane protein 51
TMEM62 transmembrane protein 62
TPST1 tyrosylprotein sulfotransferase 1
TRAPPC12 trafficking protein particle complex 12
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBIAD1 UbiA prenyltransferase domain containing 1
UBXN6 UBX domain protein 6
ZBED1 zinc finger, BED-type containing 1
ZFP30 ZFP30 zinc finger protein
ZNF280D zinc finger protein 280D
ZXDC ZXD family zinc finger C