tanespimycin-6978 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the tanespimycin-6978 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAM22 ADAM metallopeptidase domain 22
ADARB1 adenosine deaminase, RNA-specific, B1
ADCY7 adenylate cyclase 7
ADM adrenomedullin
ANG angiogenin, ribonuclease, RNase A family, 5
BBS9 Bardet-Biedl syndrome 9
BCAS1 breast carcinoma amplified sequence 1
BMP4 bone morphogenetic protein 4
BST2 bone marrow stromal cell antigen 2
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COPA coatomer protein complex, subunit alpha
CREB3L2 cAMP responsive element binding protein 3-like 2
CSRP2 cysteine and glycine-rich protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO2 deiodinase, iodothyronine, type II
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EFNA3 ephrin-A3
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ESR1 estrogen receptor 1
FAM110B family with sequence similarity 110, member B
FAM204A family with sequence similarity 204, member A
FAM212B family with sequence similarity 212, member B
FBXO21 F-box protein 21
FGFR2 fibroblast growth factor receptor 2
FZD7 frizzled class receptor 7
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GSK3A glycogen synthase kinase 3 alpha
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXB5 homeobox B5
HOXC10 homeobox C10
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IRS2 insulin receptor substrate 2
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KIAA0319L KIAA0319-like
KMT2A lysine (K)-specific methyltransferase 2A
LDLR low density lipoprotein receptor
LGALS9 lectin, galactoside-binding, soluble, 9
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LPIN1 lipin 1
MAPK14 mitogen-activated protein kinase 14
MAPK7 mitogen-activated protein kinase 7
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MED16 mediator complex subunit 16
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAP1L2 nucleosome assembly protein 1-like 2
NEBL nebulette
NF2 neurofibromin 2 (merlin)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUMA1 nuclear mitotic apparatus protein 1
OSBPL1A oxysterol binding protein-like 1A
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE4DIP phosphodiesterase 4D interacting protein
PER1 period circadian clock 1
PLXNA3 plexin A3
PMCH pro-melanin-concentrating hormone
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTP4A3 protein tyrosine phosphatase type IVA, member 3
QKI QKI, KH domain containing, RNA binding
RABGGTB Rab geranylgeranyltransferase, beta subunit
RFPL2 ret finger protein-like 2
RFPL3 ret finger protein-like 3
RGS2 regulator of G-protein signaling 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SENP6 SUMO1/sentrin specific peptidase 6
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TES testin LIM domain protein
TMEM53 transmembrane protein 53
TRIM2 tripartite motif containing 2
TSPYL2 TSPY-like 2
ULBP2 UL16 binding protein 2
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR1 WD repeat domain 1
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNF329 zinc finger protein 329

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ANKRD36B ankyrin repeat domain 36B
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP13A2 ATPase type 13A2
BIK BCL2-interacting killer (apoptosis-inducing)
BPGM 2,3-bisphosphoglycerate mutase
C9ORF3 chromosome 9 open reading frame 3
CCNE2 cyclin E2
CD3EAP CD3e molecule, epsilon associated protein
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDK3 cyclin-dependent kinase 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNPY3 canopy FGF signaling regulator 3
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CXORF56 chromosome X open reading frame 56
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNAAF2 dynein, axonemal, assembly factor 2
ECD ecdysoneless homolog (Drosophila)
EGLN2 egl-9 family hypoxia-inducible factor 2
EGR3 early growth response 3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPS8L2 EPS8-like 2
EVL Enah/Vasp-like
FAM50B family with sequence similarity 50, member B
FAM57A family with sequence similarity 57, member A
FHOD1 formin homology 2 domain containing 1
FJX1 four jointed box 1 (Drosophila)
FKBP10 FK506 binding protein 10, 65 kDa
FOXD1 forkhead box D1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IFT88 intraflagellar transport 88
KCTD15 potassium channel tetramerization domain containing 15
KLC2 kinesin light chain 2
KLF10 Kruppel-like factor 10
LAMA3 laminin, alpha 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LINC00339 long intergenic non-protein coding RNA 339
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LZTR1 leucine-zipper-like transcription regulator 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP6D1 MAP6 domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED22 mediator complex subunit 22
MEX3C mex-3 RNA binding family member C
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MNT MAX network transcriptional repressor
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAM2 neural cell adhesion molecule 2
NPY1R neuropeptide Y receptor Y1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae)
PARD6A par-6 family cell polarity regulator alpha
PCF11 PCF11 cleavage and polyadenylation factor subunit
PMEPA1 prostate transmembrane protein, androgen induced 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PODXL podocalyxin-like
PUS1 pseudouridylate synthase 1
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PYCRL pyrroline-5-carboxylate reductase-like
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM14 RNA binding motif protein 14
RIBC2 RIB43A domain with coiled-coils 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCO2 SCO2 cytochrome c oxidase assembly protein
SETD6 SET domain containing 6
SETMAR SET domain and mariner transposase fusion gene
SIDT1 SID1 transmembrane family, member 1
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SPATA2L spermatogenesis associated 2-like
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
SYTL2 synaptotagmin-like 2
TCTA T-cell leukemia translocation altered
TFRC transferrin receptor
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TRAF5 TNF receptor-associated factor 5
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBA3 ubiquitin-like modifier activating enzyme 3
UBIAD1 UbiA prenyltransferase domain containing 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB10 zinc finger and BTB domain containing 10
ZNF124 zinc finger protein 124
ZNF787 zinc finger protein 787
ZXDC ZXD family zinc finger C