tanespimycin-6166 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tanespimycin-6166 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACVR1B activin A receptor, type IB
ADGRL2 adhesion G protein-coupled receptor L2
ADRA2C adrenoceptor alpha 2C
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AQP9 aquaporin 9
BAG3 BCL2-associated athanogene 3
BAIAP2 BAI1-associated protein 2
BCL2L1 BCL2-like 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCL22 chemokine (C-C motif) ligand 22
CCNG2 cyclin G2
CD47 CD47 molecule
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLTA clathrin, light chain A
CNPY4 canopy FGF signaling regulator 4
COL4A2 collagen, type IV, alpha 2
CREM cAMP responsive element modulator
CRYZ crystallin, zeta (quinone reductase)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EML2 echinoderm microtubule associated protein like 2
FAM13A family with sequence similarity 13, member A
FAM189A2 family with sequence similarity 189, member A2
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGFR1 fibroblast growth factor receptor 1
FKBP4 FK506 binding protein 4, 59kDa
GPR153 G protein-coupled receptor 153
GRIK5 glutamate receptor, ionotropic, kainate 5
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA7 homeobox A7
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1L heat shock 70kDa protein 1-like
HSPA4L heat shock 70kDa protein 4-like
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IL7R interleukin 7 receptor
KCNK10 potassium channel, two pore domain subfamily K, member 10
KLHL36 kelch-like family member 36
MAGEB4 melanoma antigen family B4
MBNL2 muscleblind-like splicing regulator 2
MBOAT2 membrane bound O-acyltransferase domain containing 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MST1L macrophage stimulating 1-like
MUC6 mucin 6, oligomeric mucus/gel-forming
NNAT neuronatin
NOD2 nucleotide-binding oligomerization domain containing 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PERP PERP, TP53 apoptosis effector
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PIGR polymeric immunoglobulin receptor
PIR pirin (iron-binding nuclear protein)
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PMP22 peripheral myelin protein 22
PPID peptidylprolyl isomerase D
PRDM10 PR domain containing 10
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
REC8 REC8 meiotic recombination protein
RTEL1 regulator of telomere elongation helicase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3D21 SH3 domain containing 21
SNAP23 synaptosomal-associated protein, 23kDa
SPATS2L spermatogenesis associated, serine-rich 2-like
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAC SH3 and cysteine rich domain
TEF thyrotrophic embryonic factor
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TOP3A topoisomerase (DNA) III alpha
TP53I11 tumor protein p53 inducible protein 11
TRD T cell receptor delta locus
TRIM23 tripartite motif containing 23
TSC2 tuberous sclerosis 2
WSCD1 WSC domain containing 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZBTB20 zinc finger and BTB domain containing 20
ZBTB38 zinc finger and BTB domain containing 38
ZIM2 zinc finger, imprinted 2
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AEN apoptosis enhancing nuclease
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ARRB1 arrestin, beta 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BHLHE41 basic helix-loop-helix family, member e41
BRIX1 BRX1, biogenesis of ribosomes
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C17ORF70 chromosome 17 open reading frame 70
C5ORF28 chromosome 5 open reading frame 28
C9ORF3 chromosome 9 open reading frame 3
CCDC86 coiled-coil domain containing 86
CDR2L cerebellar degeneration-related protein 2-like
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHML choroideremia-like (Rab escort protein 2)
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
COA7 cytochrome c oxidase assembly factor 7 (putative)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDN dendrin
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENDOG endonuclease G
EXOSC5 exosome component 5
FAM86B1 family with sequence similarity 86, member B1
FJX1 four jointed box 1 (Drosophila)
FURIN furin (paired basic amino acid cleaving enzyme)
FYCO1 FYVE and coiled-coil domain containing 1
HYAL2 hyaluronoglucosaminidase 2
HYAL3 hyaluronoglucosaminidase 3
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRX5 iroquois homeobox 5
KIF21B kinesin family member 21B
KLK5 kallikrein-related peptidase 5
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MEGF8 multiple EGF-like-domains 8
METTL8 methyltransferase like 8
MNT MAX network transcriptional repressor
MOGS mannosyl-oligosaccharide glucosidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOP2 NOP2 nucleolar protein
NR1D2 nuclear receptor subfamily 1, group D, member 2
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NXT1 nuclear transport factor 2-like export factor 1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PDZD7 PDZ domain containing 7
PIEZO1 piezo-type mechanosensitive ion channel component 1
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PYCR1 pyrroline-5-carboxylate reductase 1
RABEPK Rab9 effector protein with kelch motifs
REEP4 receptor accessory protein 4
RETN resistin
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RFXAP regulatory factor X-associated protein
RGS16 regulator of G-protein signaling 16
RHOBTB2 Rho-related BTB domain containing 2
RPP25 ribonuclease P/MRP 25kDa subunit
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCO2 SCO2 cytochrome c oxidase assembly protein
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMAD7 SMAD family member 7
STC2 stanniocalcin 2
STEAP3 STEAP family member 3, metalloreductase
STRA13 stimulated by retinoic acid 13
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TCTA T-cell leukemia translocation altered
TERT telomerase reverse transcriptase
TFB2M transcription factor B2, mitochondrial
THEM6 thioesterase superfamily member 6
TICAM1 toll-like receptor adaptor molecule 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM110 transmembrane protein 110
TNF tumor necrosis factor
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
TXLNG taxilin gamma
UNG uracil-DNA glycosylase
USB1 U6 snRNA biogenesis 1
WDR3 WD repeat domain 3
WNT10B wingless-type MMTV integration site family, member 10B
ZBED1 zinc finger, BED-type containing 1
ZBED8 zinc finger, BED-type containing 8