tanespimycin-4450 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the tanespimycin-4450 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADCY7 adenylate cyclase 7
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BAAT bile acid CoA:amino acid N-acyltransferase
BLZF1 basic leucine zipper nuclear factor 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD22 CD22 molecule
CD52 CD52 molecule
CDK20 cyclin-dependent kinase 20
CLCN7 chloride channel, voltage-sensitive 7
CLSTN3 calsyntenin 3
COL17A1 collagen, type XVII, alpha 1
COL3A1 collagen, type III, alpha 1
CPZ carboxypeptidase Z
CTH cystathionine gamma-lyase
DMBT1 deleted in malignant brain tumors 1
DMRT1 doublesex and mab-3 related transcription factor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
EDRF1 erythroid differentiation regulatory factor 1
EFHC2 EF-hand domain (C-terminal) containing 2
FBN2 fibrillin 2
FBXO21 F-box protein 21
GABARAPL1 GABA(A) receptor-associated protein like 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GRAMD1B GRAM domain containing 1B
GVINP1 GTPase, very large interferon inducible pseudogene 1
HFE hemochromatosis
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC4 homeobox C4
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IL11 interleukin 11
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT6A keratin 6A, type II
LRRK1 leucine-rich repeat kinase 1
MIER2 mesoderm induction early response 1, family member 2
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MTMR1 myotubularin related protein 1
MUC8 mucin 8
MYBPC3 myosin binding protein C, cardiac
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
NRF1 nuclear respiratory factor 1
OSGIN1 oxidative stress induced growth inhibitor 1
OXTR oxytocin receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBX2 pre-B-cell leukemia homeobox 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4B phosphodiesterase 4B, cAMP-specific
PDZD2 PDZ domain containing 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POU5F1B POU class 5 homeobox 1B
PRDM1 PR domain containing 1, with ZNF domain
PRKCE protein kinase C, epsilon
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRR protein tyrosine phosphatase, receptor type, R
RASAL2 RAS protein activator like 2
RFPL2 ret finger protein-like 2
RGCC regulator of cell cycle
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLN sarcolipin
SMG7 SMG7 nonsense mediated mRNA decay factor
SYNPO synaptopodin
TBCD tubulin folding cofactor D
TCP11L1 t-complex 11, testis-specific-like 1
TGFB2 transforming growth factor, beta 2
THSD4 thrombospondin, type I, domain containing 4
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TPR translocated promoter region, nuclear basket protein
WDR33 WD repeat domain 33
WSB1 WD repeat and SOCS box containing 1
ZBTB3 zinc finger and BTB domain containing 3
ZC3H13 zinc finger CCCH-type containing 13
ZNF362 zinc finger protein 362

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ADGRB2 adhesion G protein-coupled receptor B2
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARPIN actin-related protein 2/3 complex inhibitor
ASIC3 acid sensing (proton gated) ion channel 3
BMP4 bone morphogenetic protein 4
C11ORF68 chromosome 11 open reading frame 68
C14ORF93 chromosome 14 open reading frame 93
CAPN5 calpain 5
CCNE1 cyclin E1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPT centromere protein T
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIDEB cell death-inducing DFFA-like effector b
CNGA1 cyclic nucleotide gated channel alpha 1
CNTN1 contactin 1
DDN dendrin
DEPDC5 DEP domain containing 5
DEPTOR DEP domain containing MTOR-interacting protein
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
ELP6 elongator acetyltransferase complex subunit 6
EPN3 epsin 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL7 F-box and leucine-rich repeat protein 7
GAS8 growth arrest-specific 8
GBX2 gastrulation brain homeobox 2
GJC1 gap junction protein, gamma 1, 45kDa
GMEB1 glucocorticoid modulatory element binding protein 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRB7 growth factor receptor-bound protein 7
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HAS2 hyaluronan synthase 2
HDAC11 histone deacetylase 11
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H3H histone cluster 1, H3h
HOXA4 homeobox A4
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IQCG IQ motif containing G
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITPKA inositol-trisphosphate 3-kinase A
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA1107 KIAA1107
KLHL36 kelch-like family member 36
MCC mutated in colorectal cancers
NCALD neurocalcin delta
NXPH4 neurexophilin 4
ORC1 origin recognition complex, subunit 1
PADI1 peptidyl arginine deiminase, type I
PCOLCE procollagen C-endopeptidase enhancer
PEX26 peroxisomal biogenesis factor 26
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLA1A phospholipase A1 member A
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
POLM polymerase (DNA directed), mu
PQLC2 PQ loop repeat containing 2
PRKG2 protein kinase, cGMP-dependent, type II
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RIBC2 RIB43A domain with coiled-coils 2
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCARA3 scavenger receptor class A, member 3
SCIN scinderin
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A10 solute carrier family 38, member 10
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMO smoothened, frizzled class receptor
SP1 Sp1 transcription factor
SPAG4 sperm associated antigen 4
SPATA2L spermatogenesis associated 2-like
SSBP3 single stranded DNA binding protein 3
STON1 stonin 1
TMEM206 transmembrane protein 206
TRIM25 tripartite motif containing 25
TRIM9 tripartite motif containing 9
WDR25 WD repeat domain 25
WNT16 wingless-type MMTV integration site family, member 16
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC14 zinc finger, DHHC-type containing 14
ZFHX3 zinc finger homeobox 3
ZMAT5 zinc finger, matrin-type 5
ZNF107 zinc finger protein 107
ZNF137P zinc finger protein 137, pseudogene
ZNF141 zinc finger protein 141
ZNF862 zinc finger protein 862
ZXDC ZXD family zinc finger C