tanespimycin-2685 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the tanespimycin-2685 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABHD3 abhydrolase domain containing 3
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACSM1 acyl-CoA synthetase medium-chain family member 1
ACSM3 acyl-CoA synthetase medium-chain family member 3
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ANXA1 annexin A1
BAG3 BCL2-associated athanogene 3
BLZF1 basic leucine zipper nuclear factor 1
CACYBP calcyclin binding protein
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CD84 CD84 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CENPO centromere protein O
CEP135 centrosomal protein 135kDa
CES3 carboxylesterase 3
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CNGB3 cyclic nucleotide gated channel beta 3
COL19A1 collagen, type XIX, alpha 1
CREM cAMP responsive element modulator
CRYZ crystallin, zeta (quinone reductase)
DCAF15 DDB1 and CUL4 associated factor 15
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUX4L8 double homeobox 4 like 8
EED embryonic ectoderm development
EGR4 early growth response 4
FAM13A family with sequence similarity 13, member A
FAS Fas cell surface death receptor
FBXO40 F-box protein 40
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FLOT1 flotillin 1
FOXO4 forkhead box O4
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
GZMK granzyme K (granzyme 3; tryptase II)
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HOXD10 homeobox D10
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL6ST interleukin 6 signal transducer
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCTD20 potassium channel tetramerization domain containing 20
KYNU kynureninase
LEP leptin
MAU2 MAU2 sister chromatid cohesion factor
MBNL2 muscleblind-like splicing regulator 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCTP2 multiple C2 domains, transmembrane 2
MED14 mediator complex subunit 14
MOB3B MOB kinase activator 3B
MOXD1 monooxygenase, DBH-like 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYO10 myosin X
NMUR1 neuromedin U receptor 1
NPTXR neuronal pentraxin receptor
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PACRG PARK2 co-regulated
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PHACTR1 phosphatase and actin regulator 1
PIR pirin (iron-binding nuclear protein)
PLSCR1 phospholipid scramblase 1
PPID peptidylprolyl isomerase D
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRKACB protein kinase, cAMP-dependent, catalytic, beta
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3D21 SH3 domain containing 21
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SMC1A structural maintenance of chromosomes 1A
SOGA1 suppressor of glucose, autophagy associated 1
SPATS2L spermatogenesis associated, serine-rich 2-like
SRPK3 SRSF protein kinase 3
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STIP1 stress-induced phosphoprotein 1
STON1 stonin 1
TAPT1 transmembrane anterior posterior transformation 1
THBS1 thrombospondin 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNP2 transition protein 2 (during histone to protamine replacement)
TSPAN2 tetraspanin 2
TUBA4B tubulin, alpha 4b
ZBTB38 zinc finger and BTB domain containing 38
ZNF337 zinc finger protein 337
ZNF415 zinc finger protein 415

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AEN apoptosis enhancing nuclease
ARHGAP10 Rho GTPase activating protein 10
ARMCX4 armadillo repeat containing, X-linked 4
ARPC5L actin related protein 2/3 complex, subunit 5-like
BAHCC1 BAH domain and coiled-coil containing 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BBC3 BCL2 binding component 3
BPHL biphenyl hydrolase-like (serine hydrolase)
C17ORF70 chromosome 17 open reading frame 70
C9ORF9 chromosome 9 open reading frame 9
C9ORF91 chromosome 9 open reading frame 91
CCDC86 coiled-coil domain containing 86
CCNE1 cyclin E1
CD14 CD14 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDR2L cerebellar degeneration-related protein 2-like
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST10 carbohydrate sulfotransferase 10
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
DDN dendrin
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DHRS11 dehydrogenase/reductase (SDR family) member 11
EHD4 EH-domain containing 4
ELMO3 engulfment and cell motility 3
ENDOG endonuclease G
FAM86B1 family with sequence similarity 86, member B1
FJX1 four jointed box 1 (Drosophila)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GFOD1 glucose-fructose oxidoreductase domain containing 1
HMGA2 high mobility group AT-hook 2
HRAS Harvey rat sarcoma viral oncogene homolog
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IDI2-AS1 IDI2 antisense RNA 1
IER2 immediate early response 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBE inhibin, beta E
KIF21B kinesin family member 21B
KLF3 Kruppel-like factor 3 (basic)
LIG4 ligase IV, DNA, ATP-dependent
LONRF3 LON peptidase N-terminal domain and ring finger 3
LTB lymphotoxin beta (TNF superfamily, member 3)
LY6E lymphocyte antigen 6 complex, locus E
MAT2A methionine adenosyltransferase II, alpha
METTL21B methyltransferase like 21B
MOCS3 molybdenum cofactor synthesis 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCF1C neutrophil cytosolic factor 1C pseudogene
NNAT neuronatin
NR1D2 nuclear receptor subfamily 1, group D, member 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PDZD7 PDZ domain containing 7
PGP phosphoglycolate phosphatase
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRDM13 PR domain containing 13
PTGES2 prostaglandin E synthase 2
PTRH2 peptidyl-tRNA hydrolase 2
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PYCRL pyrroline-5-carboxylate reductase-like
PYGB phosphorylase, glycogen; brain
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RGS16 regulator of G-protein signaling 16
RGS19 regulator of G-protein signaling 19
RNF122 ring finger protein 122
RNF19B ring finger protein 19B
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SETD6 SET domain containing 6
SLC16A4 solute carrier family 16, member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SPATA2L spermatogenesis associated 2-like
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC2 stanniocalcin 2
STRA13 stimulated by retinoic acid 13
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TCTA T-cell leukemia translocation altered
TERT telomerase reverse transcriptase
TEX2 testis expressed 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM177 transmembrane protein 177
TMEM223 transmembrane protein 223
TNF tumor necrosis factor
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3
UBIAD1 UbiA prenyltransferase domain containing 1
UNC13B unc-13 homolog B (C. elegans)
VN1R1 vomeronasal 1 receptor 1
WNT10B wingless-type MMTV integration site family, member 10B
WT1-AS WT1 antisense RNA
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768
ZXDC ZXD family zinc finger C