tamoxifen-375 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tamoxifen-375 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
AKAP9 A kinase (PRKA) anchor protein 9
AQP3 aquaporin 3 (Gill blood group)
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARMC4 armadillo repeat containing 4
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATG13 autophagy related 13
ATXN2L ataxin 2-like
ATXN8OS ATXN8 opposite strand (non-protein coding)
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL7C B-cell CLL/lymphoma 7C
C2ORF27A chromosome 2 open reading frame 27A
CA9 carbonic anhydrase IX
CBX8 chromobox homolog 8
CCDC176 coiled-coil domain containing 176
CCNG2 cyclin G2
CD82 CD82 molecule
CDC37 cell division cycle 37
CDC37L1 cell division cycle 37-like 1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CFAP70 cilia and flagella associated protein 70
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
COX5B cytochrome c oxidase subunit Vb
CXCR4 chemokine (C-X-C motif) receptor 4
DTNB dystrobrevin, beta
DXO decapping exoribonuclease
ECE2 endothelin converting enzyme 2
EGR1 early growth response 1
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
FHL3 four and a half LIM domains 3
FIP1L1 factor interacting with PAPOLA and CPSF1
FNDC3A fibronectin type III domain containing 3A
FOLR3 folate receptor 3 (gamma)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GSK3A glycogen synthase kinase 3 alpha
GTPBP2 GTP binding protein 2
H2AFY2 H2A histone family, member Y2
HAND1 heart and neural crest derivatives expressed 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HLA-DOA major histocompatibility complex, class II, DO alpha
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IFNA17 interferon, alpha 17
IL1R1 interleukin 1 receptor, type I
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KXD1 KxDL motif containing 1
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRP6 low density lipoprotein receptor-related protein 6
MBNL2 muscleblind-like splicing regulator 2
MRC2 mannose receptor, C type 2
NELL2 NEL-like 2 (chicken)
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUDCD3 NudC domain containing 3
NUP214 nucleoporin 214kDa
PALLD palladin, cytoskeletal associated protein
PDE4DIP phosphodiesterase 4D interacting protein
PEPD peptidase D
PLCD1 phospholipase C, delta 1
PNISR PNN-interacting serine/arginine-rich protein
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PON1 paraoxonase 1
PRDM11 PR domain containing 11
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTGES prostaglandin E synthase
PUS3 pseudouridylate synthase 3
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB27B RAB27B, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RND2 Rho family GTPase 2
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUNX2 runt-related transcription factor 2
SCAMP1 secretory carrier membrane protein 1
SEC23A Sec23 homolog A (S. cerevisiae)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH2B2 SH2B adaptor protein 2
SIGMAR1 sigma non-opioid intracellular receptor 1
SIRPA signal-regulatory protein alpha
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNTA1 syntrophin, alpha 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRPK2 SRSF protein kinase 2
TBCD tubulin folding cofactor D
TESK2 testis-specific kinase 2
TMEM53 transmembrane protein 53
TMPRSS2 transmembrane protease, serine 2
TMPRSS5 transmembrane protease, serine 5
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIO trio Rho guanine nucleotide exchange factor
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
WASL Wiskott-Aldrich syndrome-like
ZMYM4 zinc finger, MYM-type 4
ZNF408 zinc finger protein 408
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
AEN apoptosis enhancing nuclease
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AIM2 absent in melanoma 2
AMPD2 adenosine monophosphate deaminase 2
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARG1 arginase 1
AXIN1 axin 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BACE1 beta-site APP-cleaving enzyme 1
BTBD2 BTB (POZ) domain containing 2
C1QTNF1 C1q and tumor necrosis factor related protein 1
CA7 carbonic anhydrase VII
CAV3 caveolin 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD3D CD3d molecule, delta (CD3-TCR complex)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CGREF1 cell growth regulator with EF-hand domain 1
CHGB chromogranin B
COPZ2 coatomer protein complex, subunit zeta 2
CRYAB crystallin, alpha B
CSF1R colony stimulating factor 1 receptor
CTSE cathepsin E
CXCL12 chemokine (C-X-C motif) ligand 12
DAGLA diacylglycerol lipase, alpha
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DLK2 delta-like 2 homolog (Drosophila)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR3 early growth response 3
ERF Ets2 repressor factor
EXOSC9 exosome component 9
FAM222B family with sequence similarity 222, member B
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FKBP10 FK506 binding protein 10, 65 kDa
FOLR2 folate receptor 2 (fetal)
FSTL1 follistatin-like 1
GAB2 GRB2-associated binding protein 2
GAS8-AS1 GAS8 antisense RNA 1
GDF2 growth differentiation factor 2
GMEB1 glucocorticoid modulatory element binding protein 1
GPR173 G protein-coupled receptor 173
GUSBP3 glucuronidase, beta pseudogene 3
HDAC11 histone deacetylase 11
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMP19 HMP19 protein
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INE1 inactivation escape 1 (non-protein coding)
ITK IL2-inducible T-cell kinase
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KLF11 Kruppel-like factor 11
KLHL25 kelch-like family member 25
LINC00574 long intergenic non-protein coding RNA 574
LOC440895 two pore channel 3 pseudogene
LRRC61 leucine rich repeat containing 61
LTBP2 latent transforming growth factor beta binding protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGOHB mago-nashi homolog B (Drosophila)
MAL mal, T-cell differentiation protein
MUC2 mucin 2, oligomeric mucus/gel-forming
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC3 myosin binding protein C, cardiac
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARFL nuclear prelamin A recognition factor-like
NPY1R neuropeptide Y receptor Y1
NUPL1 nucleoporin like 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PACS1 phosphofurin acidic cluster sorting protein 1
PADI1 peptidyl arginine deiminase, type I
PF4 platelet factor 4
POMT2 protein-O-mannosyltransferase 2
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASIP1 Ras interacting protein 1
RGSL1 regulator of G-protein signaling like 1
SCGN secretagogin, EF-hand calcium binding protein
SETMAR SET domain and mariner transposase fusion gene
SNORA21 small nucleolar RNA, H/ACA box 21
SP4 Sp4 transcription factor
SPRR3 small proline-rich protein 3
STAB2 stabilin 2
STARD13 StAR-related lipid transfer (START) domain containing 13
STX1A syntaxin 1A (brain)
SURF2 surfeit 2
TNR tenascin R
TSKU tsukushi, small leucine rich proteoglycan
UNC93B1 unc-93 homolog B1 (C. elegans)
USP29 ubiquitin specific peptidase 29
XYLT2 xylosyltransferase II
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF211 zinc finger protein 211
ZNF358 zinc finger protein 358
ZPBP zona pellucida binding protein