tacrolimus-284 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the tacrolimus-284 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABR active BCR-related
ADGRG1 adhesion G protein-coupled receptor G1
AGRN agrin
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARNT aryl hydrocarbon receptor nuclear translocator
ASTE1 asteroid homolog 1 (Drosophila)
ATG13 autophagy related 13
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AXIN1 axin 1
BICD2 bicaudal D homolog 2 (Drosophila)
BRD2 bromodomain containing 2
BTBD2 BTB (POZ) domain containing 2
C16ORF58 chromosome 16 open reading frame 58
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2CD2L C2CD2-like
C9ORF156 chromosome 9 open reading frame 156
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALR calreticulin
CALU calumenin
CDK10 cyclin-dependent kinase 10
CLCN7 chloride channel, voltage-sensitive 7
COBL cordon-bleu WH2 repeat protein
CPD carboxypeptidase D
CPTP ceramide-1-phosphate transfer protein
DAXX death-domain associated protein
DHPS deoxyhypusine synthase
DST dystonin
FAHD2A fumarylacetoacetate hydrolase domain containing 2A
FAM192A family with sequence similarity 192, member A
FCMR Fc fragment of IgM receptor
FKBP8 FK506 binding protein 8, 38kDa
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GRAMD3 GRAM domain containing 3
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
HLA-E major histocompatibility complex, class I, E
IGF2R insulin-like growth factor 2 receptor
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
ING1 inhibitor of growth family, member 1
JMJD4 jumonji domain containing 4
KCTD13 potassium channel tetramerization domain containing 13
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LUZP1 leucine zipper protein 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MBD1 methyl-CpG binding domain protein 1
MZF1 myeloid zinc finger 1
NAGA N-acetylgalactosaminidase, alpha-
NBEAL2 neurobeachin-like 2
NOD1 nucleotide-binding oligomerization domain containing 1
NPR2 natriuretic peptide receptor 2
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NUP210 nucleoporin 210kDa
NXT2 nuclear transport factor 2-like export factor 2
PBX1 pre-B-cell leukemia homeobox 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PGP phosphoglycolate phosphatase
PHKA2 phosphorylase kinase, alpha 2 (liver)
PHOX2A paired-like homeobox 2a
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PILRB paired immunoglobin-like type 2 receptor beta
PLCD1 phospholipase C, delta 1
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PRKCD protein kinase C, delta
PRRC2A proline-rich coiled-coil 2A
PXN paxillin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARA retinoic acid receptor, alpha
RNF185 ring finger protein 185
RPUSD2 RNA pseudouridylate synthase domain containing 2
SBNO2 strawberry notch homolog 2 (Drosophila)
SCIN scinderin
SGSH N-sulfoglucosamine sulfohydrolase
SH3BP2 SH3-domain binding protein 2
SMAD3 SMAD family member 3
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TCF3 transcription factor 3
TM7SF3 transmembrane 7 superfamily member 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAPPC12 trafficking protein particle complex 12
TRIO trio Rho guanine nucleotide exchange factor
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTLL4 tubulin tyrosine ligase-like family member 4
UBE4B ubiquitination factor E4B
VAV2 vav 2 guanine nucleotide exchange factor
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBED1 zinc finger, BED-type containing 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF408 zinc finger protein 408
ZNF580 zinc finger protein 580

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ADAM30 ADAM metallopeptidase domain 30
ALX3 ALX homeobox 3
AMN amnion associated transmembrane protein
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGAP24 Rho GTPase activating protein 24
ATF3 activating transcription factor 3
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BGLAP bone gamma-carboxyglutamate (gla) protein
BTF3P12 basic transcription factor 3 pseudogene 12
C2ORF27A chromosome 2 open reading frame 27A
CAV3 caveolin 3
CCDC176 coiled-coil domain containing 176
CD3D CD3d molecule, delta (CD3-TCR complex)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CGREF1 cell growth regulator with EF-hand domain 1
CHD2 chromodomain helicase DNA binding protein 2
CPN2 carboxypeptidase N, polypeptide 2
CRYAB crystallin, alpha B
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTNNA3 catenin (cadherin-associated protein), alpha 3
CXORF21 chromosome X open reading frame 21
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DMTN dematin actin binding protein
DYSF dysferlin
FKBP6 FK506 binding protein 6, 36kDa
FLJ11710 uncharacterized protein FLJ11710
GDF10 growth differentiation factor 10
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPR182 G protein-coupled receptor 182
GPR35 G protein-coupled receptor 35
GREB1L growth regulation by estrogen in breast cancer-like
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HIST1H4E histone cluster 1, H4e
HIST1H4J histone cluster 1, H4j
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
IFI6 interferon, alpha-inducible protein 6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
INE1 inactivation escape 1 (non-protein coding)
JMJD1C jumonji domain containing 1C
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA1324 KIAA1324
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLK5 kallikrein-related peptidase 5
KRT23 keratin 23, type I
KRT8P12 keratin 8 pseudogene 12
LEFTY2 left-right determination factor 2
LINC00574 long intergenic non-protein coding RNA 574
LSM1 LSM1, U6 small nuclear RNA associated
MAGOHB mago-nashi homolog B (Drosophila)
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NEUROD4 neuronal differentiation 4
NEUROD6 neuronal differentiation 6
NIP7 NIP7, nucleolar pre-rRNA processing protein
NLRX1 NLR family member X1
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NPFFR1 neuropeptide FF receptor 1
ONECUT2 one cut homeobox 2
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PAQR6 progestin and adipoQ receptor family member VI
PARM1 prostate androgen-regulated mucin-like protein 1
PGC progastricsin (pepsinogen C)
PLA2G2F phospholipase A2, group IIF
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PNOC prepronociceptin
PNPLA6 patatin-like phospholipase domain containing 6
POTEKP POTE ankyrin domain family, member K, pseudogene
PQLC2 PQ loop repeat containing 2
PRAME preferentially expressed antigen in melanoma
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKG2 protein kinase, cGMP-dependent, type II
PSAT1 phosphoserine aminotransferase 1
RCVRN recoverin
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RPL10L ribosomal protein L10-like
RPL39L ribosomal protein L39-like
S100A1 S100 calcium binding protein A1
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SNTA1 syntrophin, alpha 1
SPON2 spondin 2, extracellular matrix protein
STAT5A signal transducer and activator of transcription 5A
STMN4 stathmin-like 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TMA7 translation machinery associated 7 homolog (S. cerevisiae)
TTTY15 testis-specific transcript, Y-linked 15 (non-protein coding)
TUBA4A tubulin, alpha 4a
VENTX VENT homeobox
WNT16 wingless-type MMTV integration site family, member 16
WNT7A wingless-type MMTV integration site family, member 7A
ZNF124 zinc finger protein 124