t-cell acute lymphoblastic leukemia cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A type of acute lymphoblastic leukaemia, ALL, a cancer of the lymphocyte-forming cells called lymphoblasts. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001106)
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Genes

231 proteins co-occuring with the tissue t-cell acute lymphoblastic leukemia cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
NOTCH1 notch 1 1.80972
TAL1 T-cell acute lymphocytic leukemia 1 1.78184
NUP214 nucleoporin 214kDa 1.61958
LMO1 LIM domain only 1 (rhombotin 1) 1.48692
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 1.48317
CD7 CD7 molecule 1.44404
TLX1 T-cell leukemia homeobox 1 1.36131
TG thyroglobulin 1.26844
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 1.21535
MAML1 mastermind-like 1 (Drosophila) 1.21001
NOTCH3 notch 3 1.202
NOTCH4 notch 4 1.19223
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.10712
NKX2-5 NK2 homeobox 5 1.09297
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 1.07397
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.07044
STIL SCL/TAL1 interrupting locus 1.03653
IL7 interleukin 7 1.03653
PTEN phosphatase and tensin homolog 0.990204
TAL2 T-cell acute lymphocytic leukemia 2 0.964631
TLX3 T-cell leukemia homeobox 3 0.924194
FPGS folylpolyglutamate synthase 0.91052
TRIB2 tribbles pseudokinase 2 0.902424
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.880781
TP53 tumor protein p53 0.878666
NKX3-1 NK3 homeobox 1 0.857574
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.848745
BCL2L1 BCL2-like 1 0.847484
PHF6 PHD finger protein 6 0.843286
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.832385
GIMAP5 GTPase, IMAP family member 5 0.829872
TCF3 transcription factor 3 0.828616
IQGAP3 IQ motif containing GTPase activating protein 3 0.819412
MTAP methylthioadenosine phosphorylase 0.81774
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.807299
CCL25 chemokine (C-C motif) ligand 25 0.804796
TRAC T cell receptor alpha constant 0.786883
HES4 hes family bHLH transcription factor 4 0.774419
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.76364
THAP1 THAP domain containing, apoptosis associated protein 1 0.760742
TSPAN7 tetraspanin 7 0.744627
RET ret proto-oncogene 0.739678
IL2 interleukin 2 0.739266
NUP155 nucleoporin 155kDa 0.738442
SMC4 structural maintenance of chromosomes 4 0.737206
GATA3 GATA binding protein 3 0.731442
CTPS2 CTP synthase 2 0.731031
TCF12 transcription factor 12 0.727741
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 0.707631
SPRY3 sprouty homolog 3 (Drosophila) 0.705993
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.702717
NMI N-myc (and STAT) interactor 0.690042
PNP purine nucleoside phosphorylase 0.66925
CDK6 cyclin-dependent kinase 6 0.668436
PHF8 PHD finger protein 8 0.666402
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.665182
CCAR1 cell division cycle and apoptosis regulator 1 0.663962
ANXA5 annexin A5 0.662742
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.659897
FADD Fas (TNFRSF6)-associated via death domain 0.658272
RUNX1 runt-related transcription factor 1 0.655836
HRAS Harvey rat sarcoma viral oncogene homolog 0.650966
NUBPL nucleotide binding protein-like 0.647316
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.643669
SRRM2 serine/arginine repetitive matrix 2 0.633549
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.631931
HEMGN hemogen 0.631527
IL2RG interleukin 2 receptor, gamma 0.626677
SSBP2 single-stranded DNA binding protein 2 0.62385
HRK harakiri, BCL2 interacting protein 0.622639
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.621831
DHFR dihydrofolate reductase 0.616183
HDAC1 histone deacetylase 1 0.606514
PTCH1 patched 1 0.604099
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 0.600881
TYMS thymidylate synthetase 0.592043
BAX BCL2-associated X protein 0.584823
TMEM132D transmembrane protein 132D 0.579617
AVEN apoptosis, caspase activation inhibitor 0.574017
MAD2L1P1 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene 1 0.572818
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.57042
GLIS2 GLIS family zinc finger 2 0.568025
KRAS Kirsten rat sarcoma viral oncogene homolog 0.564035
CD34 CD34 molecule 0.552093
AK3 adenylate kinase 3 0.546929
MNX1 motor neuron and pancreas homeobox 1 0.538604
ZAK sterile alpha motif and leucine zipper containing kinase AZK 0.537416
BCL2L10 BCL2-like 10 (apoptosis facilitator) 0.534251
MERTK MER proto-oncogene, tyrosine kinase 0.53267
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.532274
TARP TCR gamma alternate reading frame protein 0.527139
KLRF1 killer cell lectin-like receptor subfamily F, member 1 0.524377
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.523588
IL2RA interleukin 2 receptor, alpha 0.523194
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.5228
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.520829
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.520435
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.519647
RHOU ras homolog family member U 0.516497
KDM1A lysine (K)-specific demethylase 1A 0.513743
MYB v-myb avian myeloblastosis viral oncogene homolog 0.510599
SOS2 son of sevenless homolog 2 (Drosophila) 0.510206
EP300 E1A binding protein p300 0.498832
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.496092
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 0.490229
DOT1L DOT1-like histone H3K79 methyltransferase 0.489838
CDK4 cyclin-dependent kinase 4 0.483596
JUN jun proto-oncogene 0.483206
RAG2 recombination activating gene 2 0.482817
CDKN2A cyclin-dependent kinase inhibitor 2A 0.481259
AKAP9 A kinase (PRKA) anchor protein 9 0.478534
CD96 CD96 molecule 0.477367
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.476979
NOTCH2NL notch 2 N-terminal like 0.476589
HDAC2 histone deacetylase 2 0.474258
NOTCH2 notch 2 0.47348
CCND1 cyclin D1 0.472704
CD5 CD5 molecule 0.471151
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.469599
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.465335
TCL1A T-cell leukemia/lymphoma 1A 0.464561
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.454126
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.451428
FAF1 Fas (TNFRSF6) associated factor 1 0.451042
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.447961
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.444115
CD38 CD38 molecule 0.441042
CCND3 cyclin D3 0.428783
SRSF5 serine/arginine-rich splicing factor 5 0.428401
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 0.423818
JAK3 Janus kinase 3 0.423054
IL2RB interleukin 2 receptor, beta 0.419242
HOXA10 homeobox A10 0.416576
FASLG Fas ligand (TNF superfamily, member 6) 0.415434
NRCAM neuronal cell adhesion molecule 0.414673
SPEN spen family transcriptional repressor 0.413912
CHL1 cell adhesion molecule L1-like 0.413912
LMO2 LIM domain only 2 (rhombotin-like 1) 0.411631
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.411631
LCK LCK proto-oncogene, Src family tyrosine kinase 0.408972
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.400628
RBM15 RNA binding motif protein 15 0.396087
ICK intestinal cell (MAK-like) kinase 0.395331
SIGLEC9 sialic acid binding Ig-like lectin 9 0.393819
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 0.387404
EEF1A1P6 eukaryotic translation elongation factor 1 alpha 1 pseudogene 6 0.386273
MIR17 microRNA 17 0.38552
GFI1B growth factor independent 1B transcription repressor 0.38439
DTX1 deltex 1, E3 ubiquitin ligase 0.382131
GDI2 GDP dissociation inhibitor 2 0.379123
ASRGL1 asparaginase like 1 0.377996
CD4 CD4 molecule 0.371619
PRDX1 peroxiredoxin 1 0.367876
HES2 hes family bHLH transcription factor 2 0.363393
CD33 CD33 molecule 0.363393
C1QBP complement component 1, q subcomponent binding protein 0.362646
CTPS1 CTP synthase 1 0.361901
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.358919
SPRY4 sprouty homolog 4 (Drosophila) 0.357802
DLL4 delta-like 4 (Drosophila) 0.35743
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.356686
TSPAN1 tetraspanin 1 0.355942
RCOR1 REST corepressor 1 0.354826
HES5 hes family bHLH transcription factor 5 0.354084
PHB prohibitin 0.351485
RPL22 ribosomal protein L22 0.350001
TYK2 tyrosine kinase 2 0.342971
MAPK8 mitogen-activated protein kinase 8 0.342233
POLB polymerase (DNA directed), beta 0.341126
TSPAN8 tetraspanin 8 0.340019
TRAF4 TNF receptor-associated factor 4 0.334865
CD19 CD19 molecule 0.328994
RAG1 recombination activating gene 1 0.327896
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.322779
TET1 tet methylcytosine dioxygenase 1 0.316224
MET MET proto-oncogene, receptor tyrosine kinase 0.315135
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 0.314772
ICAM1 intercellular adhesion molecule 1 0.31187
NT5C2 5'-nucleotidase, cytosolic II 0.311145
MEF2C myocyte enhancer factor 2C 0.307889
DCTD dCMP deaminase 0.306805
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.306083
LDHB lactate dehydrogenase B 0.306083
GRM8 glutamate receptor, metabotropic 8 0.301398
NAPSA napsin A aspartic peptidase 0.29673
NKX2-1 NK2 homeobox 1 0.291365
HDAC9 histone deacetylase 9 0.289582
PHB2 prohibitin 2 0.28887
AIP aryl hydrocarbon receptor interacting protein 0.287447
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.284962
SIX6 SIX homeobox 6 0.284962
HDAC8 histone deacetylase 8 0.278955
MUC1 mucin 1, cell surface associated 0.276495
BHLHE40 basic helix-loop-helix family, member e40 0.276495
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.273696
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.272649
BIK BCL2-interacting killer (apoptosis-inducing) 0.270909
CTCFL CCCTC-binding factor (zinc finger protein)-like 0.266757
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.262304
STAT1 signal transducer and activator of transcription 1, 91kDa 0.261964
PLAG1 pleiomorphic adenoma gene 1 0.261624
NCR1 natural cytotoxicity triggering receptor 1 0.260606
PAX8 paired box 8 0.259254
BCL2 B-cell CLL/lymphoma 2 0.258243
MSX2 msh homeobox 2 0.256568
SET SET nuclear proto-oncogene 0.255567
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.253908
BIRC5 baculoviral IAP repeat containing 5 0.247399
CREBBP CREB binding protein 0.246124
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.245175
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.242363
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.240826
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.23781
VAV1 vav 1 guanine nucleotide exchange factor 0.237216
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.23604
PI3 peptidase inhibitor 3, skin-derived 0.234878
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.23176
NIT1 nitrilase 1 0.231206
RAP1B RAP1B, member of RAS oncogene family 0.228497
APAF1 apoptotic peptidase activating factor 1 0.226411
RAD21 RAD21 homolog (S. pombe) 0.224645
SUOX sulfite oxidase 0.224645
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.218186
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.217346
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 0.216933
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.21573
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.215341
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.214954
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.214765
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 0.21365
C19ORF48 chromosome 19 open reading frame 48 0.212413