systems Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

336 genes co-occuring with the biological term systems in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACKR3 atypical chemokine receptor 3
ADAM23 ADAM metallopeptidase domain 23
ADM2 adrenomedullin 2
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHR aryl hydrocarbon receptor
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP5 aquaporin 5
ARF1 ADP-ribosylation factor 1
ASIC1 acid sensing (proton gated) ion channel 1
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
AVP arginine vasopressin
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BMP4 bone morphogenetic protein 4
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
C1QBP complement component 1, q subcomponent binding protein
C1QTNF3 C1q and tumor necrosis factor related protein 3
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CAMP cathelicidin antimicrobial peptide
CAPNS1 calpain, small subunit 1
CASR calcium-sensing receptor
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNA2 cyclin A2
CD4 CD4 molecule
CDC45 cell division cycle 45
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLU clusterin
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
COTL1 coactosin-like F-actin binding protein 1
CRH corticotropin releasing hormone
CSNK1E casein kinase 1, epsilon
CTAG1B cancer/testis antigen 1B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DCD dermcidin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DEFB4A defensin, beta 4A
DICER1 dicer 1, ribonuclease type III
DISC1 disrupted in schizophrenia 1
DSG3 desmoglein 3
DYSF dysferlin
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELAVL1 ELAV like RNA binding protein 1
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FLNA filamin A, alpha
FMR1 fragile X mental retardation 1
FOXC2 forkhead box C2
FOXP2 forkhead box P2
FTO fat mass and obesity associated
FXN frataxin
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GFRA3 GDNF family receptor alpha 3
GH1 growth hormone 1
GHRL ghrelin/obestatin prepropeptide
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAS GNAS complex locus
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPHA2 glycoprotein hormone alpha 2
GPSM1 G-protein signaling modulator 1
GPX1 glutathione peroxidase 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSK3B glycogen synthase kinase 3 beta
GSTA3 glutathione S-transferase alpha 3
HAVCR2 hepatitis A virus cellular receptor 2
HCRT hypocretin (orexin) neuropeptide precursor
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HP haptoglobin
HSF1 heat shock transcription factor 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPB11 heat shock protein family B (small), member 11
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTT huntingtin
ICK intestinal cell (MAK-like) kinase
IFNB1 interferon, beta 1, fibroblast
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL10 interleukin 10
IL1B interleukin 1, beta
IL6 interleukin 6
IL6R interleukin 6 receptor
INS insulin
INSL3 insulin-like 3 (Leydig cell)
INSR insulin receptor
IPO4 importin 4
ISL1 ISL LIM homeobox 1
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUN jun proto-oncogene
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
KLK3 kallikrein-related peptidase 3
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KMT2A lysine (K)-specific methyltransferase 2A
LEP leptin
LEPR leptin receptor
LMX1B LIM homeobox transcription factor 1, beta
LPL lipoprotein lipase
LRP1 low density lipoprotein receptor-related protein 1
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRK2 leucine-rich repeat kinase 2
MAG myelin associated glycoprotein
MAPT microtubule-associated protein tau
MCM10 minichromosome maintenance complex component 10
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIR302A microRNA 302a
MIR31 microRNA 31
MKL2 MKL/myocardin-like 2
MSRB1 methionine sulfoxide reductase B1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
MYO5A myosin VA (heavy chain 12, myoxin)
MYRIP myosin VIIA and Rab interacting protein
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH2 notch 2
NOX1 NADPH oxidase 1
NOX4 NADPH oxidase 4
NOXA1 NADPH oxidase activator 1
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRP1 neuropilin 1
NRP2 neuropilin 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
OCRL oculocerebrorenal syndrome of Lowe
OPRM1 opioid receptor, mu 1
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene)
OXT oxytocin/neurophysin I prepropeptide
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PAX6 paired box 6
PBX1 pre-B-cell leukemia homeobox 1
PDCD10 programmed cell death 10
PDPK1 3-phosphoinositide dependent protein kinase 1
PDX1 pancreatic and duodenal homeobox 1
PENK proenkephalin
PER2 period circadian clock 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAT plasminogen activator, tissue
PLET1 placenta expressed transcript 1
PLG plasminogen
PNMT phenylethanolamine N-methyltransferase
PNOC prepronociceptin
PNPLA6 patatin-like phospholipase domain containing 6
PON1 paraoxonase 1
POU2F2 POU class 2 homeobox 2
POU5F1 POU class 5 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP5C protein phosphatase 5, catalytic subunit
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRDX2 peroxiredoxin 2
PRDX3 peroxiredoxin 3
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRNP prion protein
PROK1 prokineticin 1
PROK2 prokineticin 2
PROS1 protein S (alpha)
PRUNE2 prune homolog 2 (Drosophila)
PSG1 pregnancy specific beta-1-glycoprotein 1
PTHLH parathyroid hormone-like hormone
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAB1B RAB1B, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RAB27B RAB27B, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAN RAN, member RAS oncogene family
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RLN1 relaxin 1
RLN2 relaxin 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNASET2 ribonuclease T2
RNF4 ring finger protein 4
RTN4RL1 reticulon 4 receptor-like 1
RTN4RL2 reticulon 4 receptor-like 2
SCN5A sodium channel, voltage gated, type V alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELPLG selectin P ligand
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN3 sestrin 3
SH3PXD2A SH3 and PX domains 2A
SIRT1 sirtuin 1
SKAP1 src kinase associated phosphoprotein 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC38A2 solute carrier family 38, member 2
SLC41A1 solute carrier family 41 (magnesium transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SORT1 sortilin 1
SOX10 SRY (sex determining region Y)-box 10
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPP1 secreted phosphoprotein 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAB1 stabilin 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYK spleen tyrosine kinase
TAC3 tachykinin 3
TACR1 tachykinin receptor 1
TACR3 tachykinin receptor 3
TAL1 T-cell acute lymphocytic leukemia 1
TAS1R2 taste receptor, type 1, member 2
TAS1R3 taste receptor, type 1, member 3
TERT telomerase reverse transcriptase
TFG TRK-fused gene
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TGM2 transglutaminase 2
TH tyrosine hydroxylase
THRA thyroid hormone receptor, alpha
THRB thyroid hormone receptor, beta
TLR3 toll-like receptor 3
TNC tenascin C
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNNC1 troponin C type 1 (slow)
TNR tenascin R
TP53 tumor protein p53
TRIM68 tripartite motif containing 68
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSLP thymic stromal lymphopoietin
TXN thioredoxin
TXN2 thioredoxin 2
TXNRD1 thioredoxin reductase 1
TXNRD2 thioredoxin reductase 2
UBXN1 UBX domain protein 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VKORC1 vitamin K epoxide reductase complex, subunit 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
ZEB2 zinc finger E-box binding homeobox 2