systemic sclerosis Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies. (Human Disease Ontology, DOID_418)
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Genes

23 genes associated with the disease systemic sclerosis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
COL1A2 collagen, type I, alpha 2
CTGF connective tissue growth factor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FN1 fibronectin 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IL1A interleukin 1, alpha
NOS3 nitric oxide synthase 3 (endothelial cell)
PDGFB platelet-derived growth factor beta polypeptide
PTPRC protein tyrosine phosphatase, receptor type, C
STAT4 signal transducer and activator of transcription 4
TBX21 T-box 21
TGFB1 transforming growth factor, beta 1
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1