systemic scleroderma Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies. (Human Disease Ontology, DOID_418)
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Genes

26 genes associated with the disease systemic scleroderma in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.37597
STAT4 signal transducer and activator of transcription 4 0.945428
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.817078
TNPO3 transportin 3 0.69843
NOTCH4 notch 4 0.65413
PSORS1C2 psoriasis susceptibility 1 candidate 2 0.65413
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.65413
TNIP1 TNFAIP3 interacting protein 1 0.561725
MICB MHC class I polypeptide-related sequence B 0.552621
MICA MHC class I polypeptide-related sequence A 0.544585
TNXB tenascin XB 0.486425
ATF6B activating transcription factor 6 beta 0.464771
ZC3H10 zinc finger CCCH-type containing 10 0.429338
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.414708
PRRC2A proline-rich coiled-coil 2A 0.403461
PRRT1 proline-rich transmembrane protein 1 0.403461
SOX5 SRY (sex determining region Y)-box 5 0.403461
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.403461
CDH7 cadherin 7, type 2 0.368757
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.368757
HSPA1L heat shock 70kDa protein 1-like 0.327313
IRF5 interferon regulatory factor 5 0.311576
MUC21 mucin 21, cell surface associated 0.274608
GRB10 growth factor receptor-bound protein 10 0.256228
CD247 CD247 molecule 0.256228
STK19 serine/threonine kinase 19 0.256228