systemic lupus erythematosus Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. (Human Disease Ontology, DOID_9074)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0002725
Similar Terms
Downloads & Tools

Genes

136 genes associated with the systemic lupus erythematosus phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
MSH5 mutS homolog 5 2.58317
CFB complement factor B 2.57545
C6ORF10 chromosome 6 open reading frame 10 2.5284
STAT4 signal transducer and activator of transcription 4 2.47733
HLA-DRA major histocompatibility complex, class II, DR alpha 2.38272
TNXB tenascin XB 2.20662
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.17141
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.07153
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 2.04537
TNPO3 transportin 3 1.86379
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.85741
GPR19 G protein-coupled receptor 19 1.83896
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.81736
CD80 CD80 molecule 1.77862
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 1.75033
BLK BLK proto-oncogene, Src family tyrosine kinase 1.67429
UHRF1BP1 UHRF1 binding protein 1 1.5645
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.52822
WDFY4 WDFY family member 4 1.52026
LOC100506023 uncharacterized LOC100506023 1.5181
C6ORF106 chromosome 6 open reading frame 106 1.51449
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 1.48419
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.48419
XKR6 XK, Kell blood group complex subunit-related family, member 6 1.47638
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.47083
BANK1 B-cell scaffold protein with ankyrin repeats 1 1.4581
PXK PX domain containing serine/threonine kinase 1.45654
ARID5B AT rich interactive domain 5B (MRF1-like) 1.45654
KIAA0319L KIAA0319-like 1.43716
PHRF1 PHD and ring finger domains 1 1.40061
FAM167A-AS1 FAM167A antisense RNA 1 1.38847
LRRC18 leucine rich repeat containing 18 1.37522
TNIP1 TNFAIP3 interacting protein 1 1.32793
LYN LYN proto-oncogene, Src family tyrosine kinase 1.279
IRF5 interferon regulatory factor 5 1.279
AFF1 AF4/FMR2 family, member 1 1.25845
C10ORF11 chromosome 10 open reading frame 11 1.24999
ELF1 E74-like factor 1 (ets domain transcription factor) 1.24751
NOTCH4 notch 4 1.24347
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 1.24271
CREBL2 cAMP responsive element binding protein-like 2 1.21853
JAZF1 JAZF zinc finger 1 1.21853
HIP1 huntingtin interacting protein 1 1.21853
MUC22 mucin 22 1.20552
CLDN10 claudin 10 1.20035
C2 complement component 2 1.18504
APOM apolipoprotein M 1.18197
IL12RB2 interleukin 12 receptor, beta 2 1.16068
STK19 serine/threonine kinase 19 1.15574
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 1.15067
SCUBE1 signal peptide, CUB domain, EGF-like 1 1.14655
ATG5 autophagy related 5 1.14251
ICA1 islet cell autoantigen 1, 69kDa 1.13056
SAMD9L sterile alpha motif domain containing 9-like 1.12851
CD247 CD247 molecule 1.12009
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 1.11203
CLEC16A C-type lectin domain family 16, member A 1.08774
ZSCAN26 zinc finger and SCAN domain containing 26 1.08614
AVEN apoptosis, caspase activation inhibitor 1.08481
ZNF112 zinc finger protein 112 1.08351
MUC21 mucin 21, cell surface associated 1.08121
LAMC2 laminin, gamma 2 1.07729
LINC00305 long intergenic non-protein coding RNA 305 1.07294
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.06948
GRB2 growth factor receptor-bound protein 2 1.05454
CLCA1 chloride channel accessory 1 1.04054
BANP BTG3 associated nuclear protein 1.03374
MACROD2 MACRO domain containing 2 1.03217
DLG2 discs, large homolog 2 (Drosophila) 1.02082
RAMP1 receptor (G protein-coupled) activity modifying protein 1 1.0173
CNTNAP2 contactin associated protein-like 2 1.01418
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 1.01418
BBS5 Bardet-Biedl syndrome 5 1.01141
LEF1 lymphoid enhancer-binding factor 1 1.00059
GRK4 G protein-coupled receptor kinase 4 1.00059
YDJC YdjC homolog (bacterial) 0.99698
AUH AU RNA binding protein/enoyl-CoA hydratase 0.988085
UPK1B uroplakin 1B 0.978851
DPH2 DPH2 homolog (S. cerevisiae) 0.976371
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.974864
STPG2 sperm-tail PG-rich repeat containing 2 0.973975
TTC7A tetratricopeptide repeat domain 7A 0.971659
NTNG2 netrin G2 0.969142
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 0.969142
RHPN2 rhophilin, Rho GTPase binding protein 2 0.963857
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.962749
PDE4B phosphodiesterase 4B, cAMP-specific 0.95642
ANKRD44 ankyrin repeat domain 44 0.935608
ANXA6 annexin A6 0.928309
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.920973
TCF19 transcription factor 19 0.907455
LY6G6C lymphocyte antigen 6 complex, locus G6C 0.9057
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 0.899912
ZSCAN31 zinc finger and SCAN domain containing 31 0.897419
ZNRD1 zinc ribbon domain containing 1 0.89672
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.882984
OR4A15 olfactory receptor, family 4, subfamily A, member 15 0.882984
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.882984
MOB3B MOB kinase activator 3B 0.882984
NEGR1 neuronal growth regulator 1 0.882984
BTN2A1 butyrophilin, subfamily 2, member A1 0.872981
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.868241
TMC2 transmembrane channel-like 2 0.868241
HSPA1B heat shock 70kDa protein 1B 0.866362
PGBD1 piggyBac transposable element derived 1 0.865832
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.86025
HCG9 HLA complex group 9 (non-protein coding) 0.83069
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.828053
SRCIN1 SRC kinase signaling inhibitor 1 0.82634
PRRC2A proline-rich coiled-coil 2A 0.817516
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.817516
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.799025
PLXNA4 plexin A4 0.795267
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.794657
DPCR1 diffuse panbronchiolitis critical region 1 0.792855
RNF39 ring finger protein 39 0.788506
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.783563
PUM1 pumilio RNA-binding family member 1 0.764625
PVT1 Pvt1 oncogene (non-protein coding) 0.739827
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.726891
TSPAN11 tetraspanin 11 0.718688
VWA7 von Willebrand factor A domain containing 7 0.711491
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.703894
HIC2 hypermethylated in cancer 2 0.656743
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.599122
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.58687
LPAR1 lysophosphatidic acid receptor 1 0.55536
AVL9 AVL9 homolog (S. cerevisiase) 0.549174
LRRC20 leucine rich repeat containing 20 0.535185
AKAP2 A kinase (PRKA) anchor protein 2 0.53086
VSIG2 V-set and immunoglobulin domain containing 2 0.519375
TMEM39A transmembrane protein 39A 0.508929
IP6K3 inositol hexakisphosphate kinase 3 0.50495
RSBN1 round spermatid basic protein 1 0.502664
SOX5 SRY (sex determining region Y)-box 5 0.495833
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 0.456794