systemic lupus erythematosus Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. (Human Disease Ontology, DOID_9074)
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Genes

133 genes associated with the disease systemic lupus erythematosus in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOH apolipoprotein H (beta-2-glycoprotein I)
ATG5 autophagy related 5
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2 B-cell CLL/lymphoma 2
BLK BLK proto-oncogene, Src family tyrosine kinase
C2 complement component 2
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
C5 complement component 5
CCL17 chemokine (C-C motif) ligand 17
CCL2 chemokine (C-C motif) ligand 2
CD19 CD19 molecule
CD22 CD22 molecule
CD40LG CD40 ligand
CD46 CD46 molecule, complement regulatory protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFB complement factor B
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DNASE1 deoxyribonuclease I
DUSP1 dual specificity phosphatase 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM167A family with sequence similarity 167, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
GHR growth hormone receptor
GSTM1 glutathione S-transferase mu 1
HIC2 hypermethylated in cancer 2
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IRF5 interferon regulatory factor 5
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DP1 killer cell immunoglobulin-like receptor, two domains, pseudogene 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KIR3DP1 killer cell immunoglobulin-like receptor, three domains, pseudogene 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LMAN1 lectin, mannose-binding, 1
LRRC18 leucine rich repeat containing 18
LTA lymphotoxin alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MBP myelin basic protein
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2
MECP2 methyl CpG binding protein 2
MICA MHC class I polypeptide-related sequence A
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NEGR1 neuronal growth regulator 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NTNG2 netrin G2
PDCD1 programmed cell death 1
PHRF1 PHD and ring finger domains 1
PRDM1 PR domain containing 1, with ZNF domain
PRL prolactin
PRLR prolactin receptor
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PXK PX domain containing serine/threonine kinase
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHBG sex hormone-binding globulin
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SOCS6 suppressor of cytokine signaling 6
SPP1 secreted phosphoprotein 1
STAT4 signal transducer and activator of transcription 4
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TLR5 toll-like receptor 5
TNF tumor necrosis factor
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TNPO3 transportin 3
TRAF1 TNF receptor-associated factor 1
TRIM21 tripartite motif containing 21
TYK2 tyrosine kinase 2
UBE2L3 ubiquitin-conjugating enzyme E2L 3
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDFY4 WDFY family member 4
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta