systemic lupus erythematosus Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. (Human Disease Ontology, DOID_9074)
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Genes

725 genes co-occuring with the disease systemic lupus erythematosus in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 2.26692
APOH apolipoprotein H (beta-2-glycoprotein I) 2.23779
IRF5 interferon regulatory factor 5 2.06941
TRIM21 tripartite motif containing 21 2.03651
CD4 CD4 molecule 1.96614
C4A complement component 4A (Rodgers blood group) 1.90847
CD79A CD79a molecule, immunoglobulin-associated alpha 1.89684
TLR7 toll-like receptor 7 1.86186
TLR9 toll-like receptor 9 1.86186
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 1.85456
TROVE2 TROVE domain family, member 2 1.84909
TRIAP1 TP53 regulated inhibitor of apoptosis 1 1.80698
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.77044
STAT4 signal transducer and activator of transcription 4 1.72593
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1.71362
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.69678
CRP C-reactive protein, pentraxin-related 1.68453
CD40LG CD40 ligand 1.65745
BLK BLK proto-oncogene, Src family tyrosine kinase 1.60681
CYCS cytochrome c, somatic 1.58225
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 1.57645
IFNA1 interferon, alpha 1 1.56978
TNF tumor necrosis factor 1.56533
C3 complement component 3 1.5569
HIST2H2AC histone cluster 2, H2ac 1.53833
HIST2H2AA4 histone cluster 2, H2aa4 1.53789
HIST2H2AA3 histone cluster 2, H2aa3 1.53789
F3 coagulation factor III (thromboplastin, tissue factor) 1.51853
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.50228
BANK1 B-cell scaffold protein with ankyrin repeats 1 1.49964
PDCD1 programmed cell death 1 1.48077
CD19 CD19 molecule 1.48077
IL10 interleukin 10 1.47242
TREX1 three prime repair exonuclease 1 1.47154
FOXP3 forkhead box P3 1.45485
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.43859
CDR1 cerebellar degeneration-related protein 1, 34kDa 1.4184
IL6 interleukin 6 1.4184
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.41095
CD40 CD40 molecule, TNF receptor superfamily member 5 1.40045
IL2 interleukin 2 1.40001
ALB albumin 1.39783
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.35725
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 1.34199
F2 coagulation factor II (thrombin) 1.33632
PRTN3 proteinase 3 1.30314
C1S complement component 1, s subcomponent 1.29833
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 1.29571
C1R complement component 1, r subcomponent 1.27606
ANXA5 annexin A5 1.26298
TNIP1 TNFAIP3 interacting protein 1 1.26124
HSPG2 heparan sulfate proteoglycan 2 1.2582
SNRPA small nuclear ribonucleoprotein polypeptide A 1.25515
PHRF1 PHD and ring finger domains 1 1.24732
CD80 CD80 molecule 1.24602
DNASE1 deoxyribonuclease I 1.24081
CD86 CD86 molecule 1.23299
CD27 CD27 molecule 1.23169
CD22 CD22 molecule 1.21565
PRL prolactin 1.19229
FAM167A family with sequence similarity 167, member A 1.19229
CD70 CD70 molecule 1.16906
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 1.16735
FCRL3 Fc receptor-like 3 1.15368
CD69 CD69 molecule 1.15283
PXK PX domain containing serine/threonine kinase 1.14263
IL31RA interleukin 31 receptor A 1.14178
CD5 CD5 molecule 1.12572
CFP complement factor properdin 1.12445
IL2RA interleukin 2 receptor, alpha 1.11519
FASLG Fas ligand (TNF superfamily, member 6) 1.11393
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.09797
PROS1 protein S (alpha) 1.09125
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.08957
ICAM1 intercellular adhesion molecule 1 1.08076
PTPN12 protein tyrosine phosphatase, non-receptor type 12 1.07614
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 1.07194
HMGB1 high mobility group box 1 1.0711
CCL2 chemokine (C-C motif) ligand 2 1.06942
WDFY4 WDFY family member 4 1.06942
PTPRD protein tyrosine phosphatase, receptor type, D 1.069
HLA-C major histocompatibility complex, class I, C 1.06858
NT5C 5', 3'-nucleotidase, cytosolic 1.06648
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 1.06648
CALR calreticulin 1.05976
IRF7 interferon regulatory factor 7 1.05597
C1QB complement component 1, q subcomponent, B chain 1.05429
C1QA complement component 1, q subcomponent, A chain 1.05219
IL21 interleukin 21 1.04756
CXCR5 chemokine (C-X-C motif) receptor 5 1.04756
THBD thrombomodulin 1.0463
IL17A interleukin 17A 1.04504
IL18 interleukin 18 1.04167
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1.03788
MPO myeloperoxidase 1.02861
C1QC complement component 1, q subcomponent, C chain 1.02566
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.02187
IGLV7-43 immunoglobulin lambda variable 7-43 1.01976
VCAM1 vascular cell adhesion molecule 1 1.01723
IL1B interleukin 1, beta 1.01301
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.00457
LYN LYN proto-oncogene, Src family tyrosine kinase 1.00161
COL7A1 collagen, type VII, alpha 1 0.995283
HLA-A major histocompatibility complex, class I, A 0.993596
B2M beta-2-microglobulin 0.989379
UHRF1BP1 UHRF1 binding protein 1 0.986007
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.977165
VWF von Willebrand factor 0.975903
CXCL10 chemokine (C-X-C motif) ligand 10 0.97296
IGHV3-9 immunoglobulin heavy variable 3-9 0.965405
IL4 interleukin 4 0.964567
SYK spleen tyrosine kinase 0.962472
TGFB1 transforming growth factor, beta 1 0.95745
HIST1H2AM histone cluster 1, H2am 0.955361
STAT1 signal transducer and activator of transcription 1, 91kDa 0.953273
SELE selectin E 0.953273
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.950769
IGHV4-39 immunoglobulin heavy variable 4-39 0.947019
HIST1H2AG histone cluster 1, H2ag 0.941196
IFIH1 interferon induced with helicase C domain 1 0.931242
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.93
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.927932
CD276 CD276 molecule 0.925039
HIST1H2AD histone cluster 1, H2ad 0.916375
HIST1H2AJ histone cluster 1, H2aj 0.916375
CENPB centromere protein B, 80kDa 0.915963
H2AFV H2A histone family, member V 0.914315
H2AFB2 H2A histone family, member B2 0.913492
H2AFY2 H2A histone family, member Y2 0.912257
H2AFB1 H2A histone family, member B1 0.912257
HIST1H2AH histone cluster 1, H2ah 0.911433
H2AFJ H2A histone family, member J 0.911022
TLR4 toll-like receptor 4 0.908553
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.906086
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.902389
HIST1H2AE histone cluster 1, H2ae 0.901567
HIST1H2AB histone cluster 1, H2ab 0.901567
PLG plasminogen 0.901156
CLEC4C C-type lectin domain family 4, member C 0.897461
IGHV4-34 immunoglobulin heavy variable 4-34 0.89623
MX1 MX dynamin-like GTPase 1 0.894589
APCS amyloid P component, serum 0.890898
LY6E lymphocyte antigen 6 complex, locus E 0.890488
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.889258
MIR146A microRNA 146a 0.883521
TYK2 tyrosine kinase 2 0.879833
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.879014
FN1 fibronectin 1 0.876148
C5AR1 complement component 5a receptor 1 0.873281
H2AFY H2A histone family, member Y 0.866731
HLA-B major histocompatibility complex, class I, B 0.866321
TLR3 toll-like receptor 3 0.861409
CD247 CD247 molecule 0.861409
PCNA proliferating cell nuclear antigen 0.859362
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.857724
CXCR3 chemokine (C-X-C motif) receptor 3 0.856905
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 0.849536
IL1RN interleukin 1 receptor antagonist 0.848716
LY9 lymphocyte antigen 9 0.846669
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.845031
F8 coagulation factor VIII, procoagulant component 0.840525
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.835607
CD180 CD180 molecule 0.834378
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.833148
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 0.824948
TLR8 toll-like receptor 8 0.823718
SP100 SP100 nuclear antigen 0.820437
BCR breakpoint cluster region 0.811411
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.811411
IFNG interferon, gamma 0.81059
LCN2 lipocalin 2 0.805667
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.799923
HIST3H2BB histone cluster 3, H2bb 0.790902
HIST2H2BF histone cluster 2, H2bf 0.788852
HIST1H2BA histone cluster 1, H2ba 0.786394
CD38 CD38 molecule 0.786394
HIST1H2BH histone cluster 1, H2bh 0.785984
HIST1H2BD histone cluster 1, H2bd 0.785984
MYD88 myeloid differentiation primary response 88 0.781479
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.778613
RNASEH2A ribonuclease H2, subunit A 0.776977
SSB Sjogren syndrome antigen B (autoantigen La) 0.776159
HIST1H2BC histone cluster 1, H2bc 0.770435
HIST1H2BF histone cluster 1, H2bf 0.770435
TOP1 topoisomerase (DNA) I 0.767576
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.767167
IFI16 interferon, gamma-inducible protein 16 0.766759
TRAF1 TNF receptor-associated factor 1 0.764718
IL7R interleukin 7 receptor 0.759008
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.756971
SNRPC small nuclear ribonucleoprotein polypeptide C 0.756564
CREM cAMP responsive element modulator 0.756156
LTF lactotransferrin 0.753713
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.752085
CD72 CD72 molecule 0.74436
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.743954
SAMHD1 SAM domain and HD domain 1 0.729762
TBX21 T-box 21 0.72612
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.724502
ACE angiotensin I converting enzyme 0.724098
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.72127
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.71925
RPL7 ribosomal protein L7 0.716425
IL1A interleukin 1, alpha 0.716425
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.714005
FCN3 ficolin (collagen/fibrinogen domain containing) 3 0.709975
PADI4 peptidyl arginine deiminase, type IV 0.708364
IRAK1 interleukin-1 receptor-associated kinase 1 0.703536
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.700321
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.698313
CD226 CD226 molecule 0.695504
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.685091
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.684292
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.680297
F5 coagulation factor V (proaccelerin, labile factor) 0.679499
SIK1 salt-inducible kinase 1 0.674315
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.671925
POMC proopiomelanocortin 0.671527
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.665563
FTH1 ferritin, heavy polypeptide 1 0.650508
SH2D1A SH2 domain containing 1A 0.646559
MBL2 mannose-binding lectin (protein C) 2, soluble 0.64577
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.64577
HARS histidyl-tRNA synthetase 0.644192
CLU clusterin 0.642615
LCK LCK proto-oncogene, Src family tyrosine kinase 0.639857
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.636708
ALPL alkaline phosphatase, liver/bone/kidney 0.634349
CAMK4 calcium/calmodulin-dependent protein kinase IV 0.633169
TMEM39A transmembrane protein 39A 0.630813
LRRC18 leucine rich repeat containing 18 0.628065
TLR2 toll-like receptor 2 0.62728
ALPPL2 alkaline phosphatase, placental-like 2 0.626495
ALPP alkaline phosphatase, placental 0.626103
LGALS8 lectin, galactoside-binding, soluble, 8 0.625319
FTL ferritin, light polypeptide 0.624535
HEBP2 heme binding protein 2 0.624143
APOA1 apolipoprotein A-I 0.622967
CFI complement factor I 0.622967
IL16 interleukin 16 0.621792
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.621792
OASL 2'-5'-oligoadenylate synthetase-like 0.621008
CD34 CD34 molecule 0.617486
CXCL13 chemokine (C-X-C motif) ligand 13 0.614356
CD59 CD59 molecule, complement regulatory protein 0.610057
MERTK MER proto-oncogene, tyrosine kinase 0.607714
SPP1 secreted phosphoprotein 1 0.606933
ENO1 enolase 1, (alpha) 0.60303
SLAMF6 SLAM family member 6 0.60147
CD44 CD44 molecule (Indian blood group) 0.597961
IFNK interferon, kappa 0.596792
MRAP melanocortin 2 receptor accessory protein 0.596402
IL23R interleukin 23 receptor 0.591727
SLK STE20-like kinase 0.591337
ISG15 ISG15 ubiquitin-like modifier 0.587833
AQP4 aquaporin 4 0.587833
DSG3 desmoglein 3 0.587444
LYZ lysozyme 0.587054
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.585887
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.585108
CTSG cathepsin G 0.58433
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.582773
IRF3 interferon regulatory factor 3 0.580828
GAS6 growth arrest-specific 6 0.58005
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.58005
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.58005
CD244 CD244 molecule, natural killer cell receptor 2B4 0.579661
IGHV3-30 immunoglobulin heavy variable 3-30 0.578883
TSPO translocator protein (18kDa) 0.573828
CXCL9 chemokine (C-X-C motif) ligand 9 0.573439
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.571107
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.571107
ESR1 estrogen receptor 1 0.570718
FLRT2 fibronectin leucine rich transmembrane protein 2 0.56722
INSR insulin receptor 0.56722
CCR7 chemokine (C-C motif) receptor 7 0.566054
COX5A cytochrome c oxidase subunit Va 0.5645
IL22 interleukin 22 0.563723
HSPA4 heat shock 70kDa protein 4 0.561781
F12 coagulation factor XII (Hageman factor) 0.561004
PARP1 poly (ADP-ribose) polymerase 1 0.561004
CD1D CD1d molecule 0.560227
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.559839
C2 complement component 2 0.559062
CFB complement factor B 0.555568
CXCL12 chemokine (C-X-C motif) ligand 12 0.554791
CFH complement factor H 0.548195
ICOS inducible T-cell co-stimulator 0.547032
TRIM68 tripartite motif containing 68 0.546644
AIM2 absent in melanoma 2 0.542767
MYDGF myeloid-derived growth factor 0.542767
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.540829
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.537731
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.537731
IFNA17 interferon, alpha 17 0.535409
CD83 CD83 molecule 0.535022
LRRC20 leucine rich repeat containing 20 0.534248
VSIG2 V-set and immunoglobulin domain containing 2 0.534248
LBH limb bud and heart development 0.534248
STK19 serine/threonine kinase 19 0.534248
OR8D4 olfactory receptor, family 8, subfamily D, member 4 0.534248
KIAA0922 KIAA0922 0.534248
TMEM187 transmembrane protein 187 0.534248
OR2H2 olfactory receptor, family 2, subfamily H, member 2 0.534248
DXO decapping exoribonuclease 0.533475
MFGE8 milk fat globule-EGF factor 8 protein 0.530381
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.529222
CNTN5 contactin 5 0.528063
ELANE elastase, neutrophil expressed 0.526132
ADA adenosine deaminase 0.525746
HLA-E major histocompatibility complex, class I, E 0.524588
PLAT plasminogen activator, tissue 0.522659
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 0.522273
UNC93B1 unc-93 homolog B1 (C. elegans) 0.521888
NCAM1 neural cell adhesion molecule 1 0.51919
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.517649
DNASE1L3 deoxyribonuclease I-like 3 0.517649
TRAC T cell receptor alpha constant 0.514186
BTLA B and T lymphocyte associated 0.513033
IL18BP interleukin 18 binding protein 0.512264
IGHV3-43 immunoglobulin heavy variable 3-43 0.511496
CD1C CD1c molecule 0.511496
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.510728
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.509192
NCF2 neutrophil cytosolic factor 2 0.507657
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.506123
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.505739
MEFV Mediterranean fever 0.504207
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.503058
IL6R interleukin 6 receptor 0.502292
IFNA21 interferon, alpha 21 0.502292
PTPRC protein tyrosine phosphatase, receptor type, C 0.498467
GSTA3 glutathione S-transferase alpha 3 0.495411
GSTA2 glutathione S-transferase alpha 2 0.493885
GSTA4 glutathione S-transferase alpha 4 0.49274
TPMT thiopurine S-methyltransferase 0.491597
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.491597
HOXC4 homeobox C4 0.491215
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.491215
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.490835
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.490072
NCL nucleolin 0.490072
MASP2 mannan-binding lectin serine peptidase 2 0.490072
SAA1 serum amyloid A1 0.489691
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.488549
GSTA1 glutathione S-transferase alpha 1 0.487027
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.486266
ZNF423 zinc finger protein 423 0.484364
PROCR protein C receptor, endothelial 0.480945
TLR5 toll-like receptor 5 0.480186
TG thyroglobulin 0.47753
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.476393
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 0.476014
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 0.474498
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.474498
VWDE von Willebrand factor D and EGF domains 0.473361
C4B complement component 4B (Chido blood group) 0.471846
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.469954
INS insulin 0.467306
MMP9 matrix metallopeptidase 9 0.466172
BTK Bruton agammaglobulinemia tyrosine kinase 0.46466
RNASEH2B ribonuclease H2, subunit B 0.463149
GSK3B glycogen synthase kinase 3 beta 0.463149
CARD17 caspase recruitment domain family, member 17 0.459751
IGLV8-61 immunoglobulin lambda variable 8-61 0.456355
CLEC17A C-type lectin domain family 17, member A 0.456355
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.453339
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.452208
NLRP1 NLR family, pyrin domain containing 1 0.448817
TRIM49 tripartite motif containing 49 0.446935
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.443547
IFNGR1 interferon gamma receptor 1 0.443171
MMP3 matrix metallopeptidase 3 0.442795
S100A8 S100 calcium binding protein A8 0.442042
GATA3 GATA binding protein 3 0.441666
CABP2 calcium binding protein 2 0.44129
ANXA2 annexin A2 0.440538
SLAMF1 signaling lymphocytic activation molecule family member 1 0.438658
ADAR adenosine deaminase, RNA-specific 0.438282
IRF1 interferon regulatory factor 1 0.43753
LTA lymphotoxin alpha 0.435651
RAVER2 ribonucleoprotein, PTB-binding 2 0.435275
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.434899
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.431144
LEP leptin 0.427765
COG2 component of oligomeric golgi complex 2 0.427015
RPF1 ribosome production factor 1 homolog (S. cerevisiae) 0.42664
HIST1H2AI histone cluster 1, H2ai 0.42664
CCR6 chemokine (C-C motif) receptor 6 0.42664
HIST1H2AK histone cluster 1, H2ak 0.42664
HLA-DMA major histocompatibility complex, class II, DM alpha 0.42664
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.42664
HIST1H2AL histone cluster 1, H2al 0.42664
RNF112 ring finger protein 112 0.426265
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.424765
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 0.421016
SFPQ splicing factor proline/glutamine-rich 0.419892
THY1 Thy-1 cell surface antigen 0.419142
H3F3A H3 histone, family 3A 0.418768
H3F3B H3 histone, family 3B (H3.3B) 0.418768
NBPF10 neuroblastoma breakpoint family, member 10 0.416896
SOD2 superoxide dismutase 2, mitochondrial 0.412405
PYHIN1 pyrin and HIN domain family, member 1 0.409414
RANBP10 RAN binding protein 10 0.407545
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.406425
SCO1 SCO1 cytochrome c oxidase assembly protein 0.406051
RPS20 ribosomal protein S20 0.406051
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.401572
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.400826
PEX5L peroxisomal biogenesis factor 5-like 0.400826
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.399707
WAPAL wings apart-like homolog (Drosophila) 0.397471
TNPO3 transportin 3 0.391513
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 0.391513
LAMP1 lysosomal-associated membrane protein 1 0.391141
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.390769
PEPD peptidase D 0.390769
TNIP2 TNFAIP3 interacting protein 2 0.389281
IRF4 interferon regulatory factor 4 0.388538
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.387423
TFRC transferrin receptor 0.385565
PON1 paraoxonase 1 0.382594
XXYLT1 xyloside xylosyltransferase 1 0.382594
CD46 CD46 molecule, complement regulatory protein 0.382223
ATG5 autophagy related 5 0.380739
CD68 CD68 molecule 0.378885
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 0.377402
IL10RA interleukin 10 receptor, alpha 0.37629
IFI44 interferon-induced protein 44 0.37555
PRF1 perforin 1 (pore forming protein) 0.374809
SDC2 syndecan 2 0.371847
CAT catalase 0.370737
MECP2 methyl CpG binding protein 2 0.369997
ANXA11 annexin A11 0.368518
ERV3-1 endogenous retrovirus group 3, member 1 0.365193
NLRP3 NLR family, pyrin domain containing 3 0.363716
TET3 tet methylcytosine dioxygenase 3 0.363716
CLTA clathrin, light chain A 0.362239
HP haptoglobin 0.362239
TADA1 transcriptional adaptor 1 0.36187
SLAMF7 SLAM family member 7 0.361133
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 0.35892
ATF6B activating transcription factor 6 beta 0.35892
IL15 interleukin 15 0.357077
HPR haptoglobin-related protein 0.356341
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.355604
CENPV centromere protein V 0.354868
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.354131
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.353027
PXMP4 peroxisomal membrane protein 4, 24kDa 0.353027
SSRP1 structure specific recognition protein 1 0.350084
BABAM1 BRISC and BRCA1 A complex member 1 0.348614
METTL16 methyltransferase like 16 0.348246
OR10K1 olfactory receptor, family 10, subfamily K, member 1 0.348246
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 0.339073
MNDA myeloid cell nuclear differentiation antigen 0.339073
MYO9B myosin IXB 0.338707
FCHSD2 FCH and double SH3 domains 2 0.338707
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.337975
MBD4 methyl-CpG binding domain protein 4 0.335778
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.332121
NELFCD negative elongation factor complex member C/D 0.328834
APOB apolipoprotein B 0.328834
CFHR4 complement factor H-related 4 0.328105
STAT2 signal transducer and activator of transcription 2, 113kDa 0.328105
PDE4C phosphodiesterase 4C, cAMP-specific 0.32774
FAM78B family with sequence similarity 78, member B 0.327375
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.327375
SF1 splicing factor 1 0.326646
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.325916
LPA lipoprotein, Lp(a) 0.324823
VSTM1 V-set and transmembrane domain containing 1 0.322273
EYS eyes shut homolog (Drosophila) 0.321181
SCARB2 scavenger receptor class B, member 2 0.319726
CCR2 chemokine (C-C motif) receptor 2 0.318272
IFI27 interferon, alpha-inducible protein 27 0.316819
OR13C4 olfactory receptor, family 13, subfamily C, member 4 0.316456
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 0.316456
HCFC1 host cell factor C1 0.314278
AICDA activation-induced cytidine deaminase 0.314278
KNG1 kininogen 1 0.312827
HSPA14 heat shock 70kDa protein 14 0.311739
TRIM22 tripartite motif containing 22 0.310652
TMEM11 transmembrane protein 11 0.310652
LMNB1 lamin B1 0.310652
CAMP cathelicidin antimicrobial peptide 0.309928
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.308118
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.307757
CXCL8 chemokine (C-X-C motif) ligand 8 0.307033
SIRPG signal-regulatory protein gamma 0.307033
MPL MPL proto-oncogene, thrombopoietin receptor 0.305948
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.305226
CD36 CD36 molecule (thrombospondin receptor) 0.304503
IGKV3-15 immunoglobulin kappa variable 3-15 0.30342
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.302337
AXL AXL receptor tyrosine kinase 0.301615
TRADD TNFRSF1A-associated via death domain 0.300173
CDHR5 cadherin-related family member 5 0.299092
IFNA2 interferon, alpha 2 0.298371
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.297651
BCL2 B-cell CLL/lymphoma 2 0.297651
PRRC2A proline-rich coiled-coil 2A 0.296931
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.296211
JAZF1 JAZF zinc finger 1 0.295492
NCR1 natural cytotoxicity triggering receptor 1 0.295132
SELL selectin L 0.295132
RORC RAR-related orphan receptor C 0.294772
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.292975
BPI bactericidal/permeability-increasing protein 0.292257
PTH parathyroid hormone 0.292257
PLA2G1B phospholipase A2, group IB (pancreas) 0.290821
YY1 YY1 transcription factor 0.289744
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.289027
SRRM1 serine/arginine repetitive matrix 1 0.287952
LMOD2 leiomodin 2 (cardiac) 0.287235
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.286877
RAG1 recombination activating gene 1 0.286519
CENPQ centromere protein Q 0.28616
PRLR prolactin receptor 0.285802
NOS3 nitric oxide synthase 3 (endothelial cell) 0.284728
AMH anti-Mullerian hormone 0.283655
MBP myelin basic protein 0.283297
IL27RA interleukin 27 receptor, alpha 0.28294
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 0.281868
HBA2 hemoglobin, alpha 2 0.280439
FADD Fas (TNFRSF6)-associated via death domain 0.278654
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.27794
CD48 CD48 molecule 0.275089
MICA MHC class I polypeptide-related sequence A 0.274021
SELPLG selectin P ligand 0.273308
CCL3L1 chemokine (C-C motif) ligand 3-like 1 0.271886
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.27153
TF transferrin 0.270108
TP53 tumor protein p53 0.269043
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 0.268332
ERVW-1 endogenous retrovirus group W, member 1 0.268332
AP1M1 adaptor-related protein complex 1, mu 1 subunit 0.267267
CD93 CD93 molecule 0.266913
JUN jun proto-oncogene 0.266558
WDR11 WD repeat domain 11 0.266203
SCARB1 scavenger receptor class B, member 1 0.265849
AGER advanced glycosylation end product-specific receptor 0.264431
ACTB actin, beta 0.264431
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 0.263368
CCL5 chemokine (C-C motif) ligand 5 0.261245
MED14 mediator complex subunit 14 0.260891
BEND3 BEN domain containing 3 0.260184
DCLK3 doublecortin-like kinase 3 0.25983
RSBN1 round spermatid basic protein 1 0.258417
IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker) 0.255594
IL12B interleukin 12B 0.255241
GSTM1 glutathione S-transferase mu 1 0.254183
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.253831
IFNLR1 interferon, lambda receptor 1 0.253831
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.253479
CFHR1 complement factor H-related 1 0.253127
SARDH sarcosine dehydrogenase 0.252774
VAV1 vav 1 guanine nucleotide exchange factor 0.252774
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.252422
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.251718
CCL21 chemokine (C-C motif) ligand 21 0.250663
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.250663
APOL1 apolipoprotein L, 1 0.249608
CENPT centromere protein T 0.249257
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.248554
FCRL4 Fc receptor-like 4 0.247852
DEFA3 defensin, alpha 3, neutrophil-specific 0.247501
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.24715
SP1 Sp1 transcription factor 0.244345
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.243295
CD24 CD24 molecule 0.243295
COL17A1 collagen, type XVII, alpha 1 0.242595
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.240847
B3GAT1 beta-1,3-glucuronyltransferase 1 0.240847
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.240148
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 0.239799
MN1 meningioma (disrupted in balanced translocation) 1 0.23945
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.238752
KIF5A kinesin family member 5A 0.238054
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.237706
NGF nerve growth factor (beta polypeptide) 0.237706
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.237009
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.23666
IRF8 interferon regulatory factor 8 0.23666
ACTG1 actin gamma 1 0.236312
TSPAN33 tetraspanin 33 0.235964
DHODH dihydroorotate dehydrogenase (quinone) 0.233878
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.23353
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.232142
GPX4 glutathione peroxidase 4 0.230755
GSTTP1 glutathione S-transferase theta pseudogene 1 0.230409
GSTT1 glutathione S-transferase theta 1 0.230409
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.230063
CADPS Ca++-dependent secretion activator 0.230063
NLN neurolysin (metallopeptidase M3 family) 0.229024
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.228679
IL4R interleukin 4 receptor 0.227642
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.227297
COL2A1 collagen, type II, alpha 1 0.226607
TRAF3IP2 TRAF3 interacting protein 2 0.226262
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.223165
NOD2 nucleotide-binding oligomerization domain containing 2 0.221793
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.220766
CCL19 chemokine (C-C motif) ligand 19 0.220081
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 0.220081
ZBTB20 zinc finger and BTB domain containing 20 0.218715
IFI44L interferon-induced protein 44-like 0.217693
SRSF5 serine/arginine-rich splicing factor 5 0.217012
GPX1 glutathione peroxidase 1 0.216672
CD84 CD84 molecule 0.215653
HMGB2 high mobility group box 2 0.215314
MARCO macrophage receptor with collagenous structure 0.212608
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.212608
NUMA1 nuclear mitotic apparatus protein 1 0.210925
CLEC16A C-type lectin domain family 16, member A 0.210589
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.210589
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 0.209583
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.209248
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.208245
TREX2 three prime repair exonuclease 2 0.207912
MCAM melanoma cell adhesion molecule 0.207578
SEPT2 septin 2 0.207578
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.206913
PLSCR1 phospholipid scramblase 1 0.206913
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 0.205916
DEK DEK proto-oncogene 0.202618
IFNB1 interferon, beta 1, fibroblast 0.20229
OR6B2 olfactory receptor, family 6, subfamily B, member 2 0.201635
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.200982
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.200982
HLA-G major histocompatibility complex, class I, G 0.200331
TNXA tenascin XA (pseudogene) 0.200331
TNXB tenascin XB 0.200331
HIST1H1B histone cluster 1, H1b 0.200006
IDO1 indoleamine 2,3-dioxygenase 1 0.199681
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.199681
GPI glucose-6-phosphate isomerase 0.199033
GNS glucosamine (N-acetyl)-6-sulfatase 0.19742
ADAMTSL1 ADAMTS-like 1 0.194865
RIPK2 receptor-interacting serine-threonine kinase 2 0.194548
ICA1 islet cell autoantigen 1, 69kDa 0.194548
AIRE autoimmune regulator 0.193915
DSG1 desmoglein 1 0.192971
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.192031
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.191719
NRP1 neuropilin 1 0.191719
IRF2 interferon regulatory factor 2 0.190786
STXBP6 syntaxin binding protein 6 (amisyn) 0.190786
FBXL20 F-box and leucine-rich repeat protein 20 0.190168
BGLAP bone gamma-carboxyglutamate (gla) protein 0.189859
PTTG1 pituitary tumor-transforming 1 0.189551
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.188326
ELF1 E74-like factor 1 (ets domain transcription factor) 0.188326
GMIP GEM interacting protein 0.188022
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.187113
FYB FYN binding protein 0.18591
ARID5B AT rich interactive domain 5B (MRF1-like) 0.185612
CAST calpastatin 0.185612
SEC61G Sec61 gamma subunit 0.18472
FOXG1 forkhead box G1 0.18472
COIL coilin 0.183835
BST2 bone marrow stromal cell antigen 2 0.183835
RUNX1 runt-related transcription factor 1 0.182666
KIF20B kinesin family member 20B 0.182086
LDLR low density lipoprotein receptor 0.181798
CA2 carbonic anhydrase II 0.181798
CFD complement factor D (adipsin) 0.18151
EXO1 exonuclease 1 0.18151
CENPC centromere protein C 0.181222
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.181222
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.180367
RABGAP1L RAB GTPase activating protein 1-like 0.17896
HIST1H1A histone cluster 1, H1a 0.178126
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.177576
GPX5 glutathione peroxidase 5 0.177029
SOCS1 suppressor of cytokine signaling 1 0.177029
S100B S100 calcium binding protein B 0.176757
EIF3C eukaryotic translation initiation factor 3, subunit C 0.175947
FYN FYN proto-oncogene, Src family tyrosine kinase 0.175411
DUT deoxyuridine triphosphatase 0.174881
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.173314
HMOX2 heme oxygenase 2 0.173057
TYROBP TYRO protein tyrosine kinase binding protein 0.172544
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.172291
TPO thyroid peroxidase 0.171785
CD8A CD8a molecule 0.171785
KIAA0319L KIAA0319-like 0.171785
BCL2L1 BCL2-like 1 0.170299
FBLL1 fibrillarin-like 1 0.170054
TRIM5 tripartite motif containing 5 0.168854
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.168148
KLHL12 kelch-like family member 12 0.167915
NAMPT nicotinamide phosphoribosyltransferase 0.167915
AVP arginine vasopressin 0.167915
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.167682
CCL3 chemokine (C-C motif) ligand 3 0.166768
TTC34 tetratricopeptide repeat domain 34 0.166544
MMEL1 membrane metallo-endopeptidase-like 1 0.166319
LPL lipoprotein lipase 0.166095
TARS threonyl-tRNA synthetase 0.166095
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.166095
GADD45A growth arrest and DNA-damage-inducible, alpha 0.165435
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.165217
RBM23 RNA binding motif protein 23 0.165217
MAVS mitochondrial antiviral signaling protein 0.165001
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 0.164786
PTK2B protein tyrosine kinase 2 beta 0.164786
CD79B CD79b molecule, immunoglobulin-associated beta 0.164786
EXOC4 exocyst complex component 4 0.163938
IRAK4 interleukin-1 receptor-associated kinase 4 0.163729
PTMS parathymosin 0.162908
B3GNT1 0.162505
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.162505
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.162109
CABIN1 calcineurin binding protein 1 0.161912
FOS FBJ murine osteosarcoma viral oncogene homolog 0.161523
MIR21 microRNA 21 0.160761
CXCL16 chemokine (C-X-C motif) ligand 16 0.160021
THPO thrombopoietin 0.15948
TIMP1 TIMP metallopeptidase inhibitor 1 0.158951
FOXJ1 forkhead box J1 0.158951
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.158951
CFHR5 complement factor H-related 5 0.158778
KLK1 kallikrein 1 0.158097
PSIP1 PC4 and SFRS1 interacting protein 1 0.157602