systemic lupus erythematosus Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. (Human Disease Ontology, DOID_9074)
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Genes

81 genes associated with the disease systemic lupus erythematosus in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CFB complement factor B 2.21059
TNXB tenascin XB 1.71485
IKZF1 IKAROS family zinc finger 1 (Ikaros) 1.50071
STAT4 signal transducer and activator of transcription 4 1.43901
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.42422
IRF5 interferon regulatory factor 5 1.29434
GPR19 G protein-coupled receptor 19 1.21385
TET3 tet methylcytosine dioxygenase 3 1.19506
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.17894
TREH trehalase (brush-border membrane glycoprotein) 1.17894
CD80 CD80 molecule 1.13588
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 1.09588
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.09588
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.965481
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.894262
UHRF1BP1 UHRF1 binding protein 1 0.894262
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.872896
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.842276
LRRC18 leucine rich repeat containing 18 0.830123
DRAM1 DNA-damage regulated autophagy modulator 1 0.820928
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.790827
TNPO3 transportin 3 0.790827
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.790827
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.774217
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.774217
ARID5B AT rich interactive domain 5B (MRF1-like) 0.752991
BLK BLK proto-oncogene, Src family tyrosine kinase 0.724323
PTTG1 pituitary tumor-transforming 1 0.724323
PHRF1 PHD and ring finger domains 1 0.682635
FAM167A-AS1 FAM167A antisense RNA 1 0.670996
LOC392787 filamin C pseudogene 0.63207
TNIP1 TNFAIP3 interacting protein 1 0.602429
LYN LYN proto-oncogene, Src family tyrosine kinase 0.561725
PXK PX domain containing serine/threonine kinase 0.544585
AFF1 AF4/FMR2 family, member 1 0.537125
ELF1 E74-like factor 1 (ets domain transcription factor) 0.52461
CREBL2 cAMP responsive element binding protein-like 2 0.486425
HIP1 huntingtin interacting protein 1 0.486425
PRDM1 PR domain containing 1, with ZNF domain 0.486425
PRR14 proline rich 14 0.464771
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.403461
LINC00208 long intergenic non-protein coding RNA 208 0.403461
ATG5 autophagy related 5 0.403461
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.403461
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.403461
ICA1 islet cell autoantigen 1, 69kDa 0.368757
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.368757
PDHX pyruvate dehydrogenase complex, component X 0.368757
ZNF689 zinc finger protein 689 0.345945
JAZF1 JAZF zinc finger 1 0.327313
CLEC16A C-type lectin domain family 16, member A 0.311576
LAMC2 laminin, gamma 2 0.297866
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.285417
ATF6B activating transcription factor 6 beta 0.264872
DDA1 DET1 and DDB1 associated 1 0.256228
COL25A1 collagen, type XXV, alpha 1 0.256228
LEF1 lymphoid enhancer-binding factor 1 0.197766
NTNG2 netrin G2 0.15771
WDFY4 WDFY family member 4 0.15771
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.15771
IL10 interleukin 10 0.15771
NOTCH4 notch 4 0.15771
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 0.15771
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.126165
GHR growth hormone receptor 0.126165
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.126165
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.100789
OSBPL8 oxysterol binding protein-like 8 0.100789
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.100789
LYST lysosomal trafficking regulator 0.080593
RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.080593
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 0.080593
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.064973
SCN10A sodium channel, voltage gated, type X alpha subunit 0.064973
NEGR1 neuronal growth regulator 1 0.064973
OR4A15 olfactory receptor, family 4, subfamily A, member 15 0.064973
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.052255
TMC2 transmembrane channel-like 2 0.052255
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.052255
NRXN1 neurexin 1 0.043246
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.043246