synaptic cleft Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released. (Gene Ontology, GO_0043083)
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Genes

159 proteins co-occuring with the synaptic cleft cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 2.26588
ACHE acetylcholinesterase (Yt blood group) 2.00765
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.96638
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.92925
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 1.76561
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 1.57875
BCHE butyrylcholinesterase 1.55254
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 1.46269
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.24498
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.23766
EGFLAM EGF-like, fibronectin type III and laminin G domains 1.2262
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.18081
SLC38A7 solute carrier family 38, member 7 1.13267
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 1.04281
LAMB2 laminin, beta 2 (laminin S) 0.998577
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.949713
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4 0.946857
COMT catechol-O-methyltransferase 0.940215
NPS neuropeptide S 0.910647
GPS1 G protein pathway suppressor 1 0.84791
GLUD2 glutamate dehydrogenase 2 0.832761
NT5E 5'-nucleotidase, ecto (CD73) 0.819452
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.798811
CBLN1 cerebellin 1 precursor 0.792854
MUSK muscle, skeletal, receptor tyrosine kinase 0.726152
SLC38A5 solute carrier family 38, member 5 0.72258
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.716791
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.714126
AGRN agrin 0.699103
NXPH1 neurexophilin 1 0.691202
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.685517
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.685517
MAOB monoamine oxidase B 0.677673
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.667693
CADM1 cell adhesion molecule 1 0.657326
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.655172
MAOA monoamine oxidase A 0.651299
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.633305
TRHDE thyrotropin-releasing hormone degrading enzyme 0.632878
GRM2 glutamate receptor, metabotropic 2 0.627335
KANK2 KN motif and ankyrin repeat domains 2 0.602752
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 0.59896
PRCP prolylcarboxypeptidase (angiotensinase C) 0.595593
BSN bassoon presynaptic cytomatrix protein 0.575495
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 0.556387
CHAT choline O-acetyltransferase 0.550599
ABAT 4-aminobutyrate aminotransferase 0.548122
NLGN1 neuroligin 1 0.546472
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 0.540706
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.538238
ASIC1 acid sensing (proton gated) ion channel 1 0.535361
NXN nucleoredoxin 0.53454
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.53454
GLUL glutamate-ammonia ligase 0.497826
GRM4 glutamate receptor, metabotropic 4 0.497015
COL13A1 collagen, type XIII, alpha 1 0.49499
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.488115
PCLO piccolo presynaptic cytomatrix protein 0.483676
CBLN3 cerebellin 3 precursor 0.468001
SLC39A5 solute carrier family 39 (zinc transporter), member 5 0.461998
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.461199
TRH thyrotropin-releasing hormone 0.457208
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.457208
PREP prolyl endopeptidase 0.452427
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.444085
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.443689
GRM1 glutamate receptor, metabotropic 1 0.441708
NLGN2 neuroligin 2 0.43696
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.419252
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.418468
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 0.40675
STX1A syntaxin 1A (brain) 0.404804
DNPEP aspartyl aminopeptidase 0.393549
SYN1 synapsin I 0.375434
CLSTN1 calsyntenin 1 0.373516
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.371599
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.368919
PGPEP1 pyroglutamyl-peptidase I 0.366241
TH tyrosine hydroxylase 0.360896
GRM7 glutamate receptor, metabotropic 7 0.357467
PRNP prion protein 0.357086
BDNF brain-derived neurotrophic factor 0.354802
TNR tenascin R 0.354042
GRM5 glutamate receptor, metabotropic 5 0.353662
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.352901
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 0.349863
TAAR1 trace amine associated receptor 1 0.349484
INPP1 inositol polyphosphate-1-phosphatase 0.347208
SLC38A4 solute carrier family 38, member 4 0.345692
AVPR1B arginine vasopressin receptor 1B 0.341907
GPER1 G protein-coupled estrogen receptor 1 0.340773
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.332848
RIMS1 regulating synaptic membrane exocytosis 1 0.330213
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 0.328708
SYP synaptophysin 0.326453
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.321201
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.320077
SGK1 serum/glucocorticoid regulated kinase 1 0.316334
EHD4 EH-domain containing 4 0.309986
NPEPPS aminopeptidase puromycin sensitive 0.309986
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.308867
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.298826
RELN reelin 0.297342
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 0.283663
GAMT guanidinoacetate N-methyltransferase 0.283295
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 0.282926
NPY neuropeptide Y 0.278877
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.278141
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.276671
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.276304
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.274468
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.264581
KIRREL2 kin of IRRE like 2 (Drosophila) 0.258381
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.258016
CADM3 cell adhesion molecule 3 0.252927
NOVA2 neuro-oncological ventral antigen 2 0.252927
DOK7 docking protein 7 0.252564
RAPSN receptor-associated protein of the synapse 0.250751
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.246046
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.239197
UTRN utrophin 0.234533
DNAH8 dynein, axonemal, heavy chain 8 0.232029
SCAMP2 secretory carrier membrane protein 2 0.225622
SCN1A sodium channel, voltage gated, type I alpha subunit 0.224558
CNOT2 CCR4-NOT transcription complex, subunit 2 0.224204
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.216111
PVALB parvalbumin 0.212627
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.21228
MME membrane metallo-endopeptidase 0.210203
TAC1 tachykinin, precursor 1 0.208825
DRD1 dopamine receptor D1 0.208481
SEC24C SEC24 family member C 0.207108
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.206423
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 0.203022
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.203022
NSF N-ethylmaleimide-sensitive factor 0.199993
EHD2 EH-domain containing 2 0.198658
HDC histidine decarboxylase 0.196339
GRM8 glutamate receptor, metabotropic 8 0.191456
SIM1 single-minded family bHLH transcription factor 1 0.187646
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.18516
SDC2 syndecan 2 0.178299
SEC24D SEC24 family member D 0.17687
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.175466
MMD monocyte to macrophage differentiation-associated 0.172201
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.171937
SYT1 synaptotagmin I 0.171673
DDN dendrin 0.170629
CORT cortistatin 0.170114
SPTBN2 spectrin, beta, non-erythrocytic 2 0.16935
ASIC2 acid sensing (proton gated) ion channel 2 0.166884
DMD dystrophin 0.165697
GDF5 growth differentiation factor 5 0.164089
RFXANK regulatory factor X-associated ankyrin-containing protein 0.162763
NRXN1 neurexin 1 0.159462
ZNF79 zinc finger protein 79 0.157578
ICAM5 intercellular adhesion molecule 5, telencephalin 0.157397
GOPC golgi-associated PDZ and coiled-coil motif containing 0.157397
CNR1 cannabinoid receptor 1 (brain) 0.157218