supraventricular arrhythmia Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A type of arrhythmia that originates above the ventricles, whereby the electrical impulse propagates down the normal His Purkinje system similar to normal sinus rhythm. (Human Phenotype Ontology, HP_0005115)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0005115
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Genes

259 genes associated with the supraventricular arrhythmia phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
STX4 syntaxin 4 3.14313
KAT8 K(lysine) acetyltransferase 8 3.04734
BCL7C B-cell CLL/lymphoma 7C 2.53587
STX1B syntaxin 1B 2.5325
VKORC1 vitamin K epoxide reductase complex, subunit 1 2.51435
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.50746
SETD1A SET domain containing 1A 2.49127
KIAA1755 KIAA1755 2.20934
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.17639
CD46 CD46 molecule, complement regulatory protein 2.12345
CCDC141 coiled-coil domain containing 141 2.12345
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.0875
SYT10 synaptotagmin X 2.08106
FADS1 fatty acid desaturase 1 2.05673
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.01845
PYCARD PYD and CARD domain containing 1.92398
FUS FUS RNA binding protein 1.91173
FBXL19 F-box and leucine-rich repeat protein 19 1.9103
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.84227
BCKDK branched chain ketoacid dehydrogenase kinase 1.83069
ZFHX3 zinc finger homeobox 3 1.77862
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.6987
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 1.64728
SYNE2 spectrin repeat containing, nuclear envelope 2 1.57861
CHRM2 cholinergic receptor, muscarinic 2 1.5645
NKX2-5 NK2 homeobox 5 1.54733
SRCAP Snf2-related CREBBP activator protein 1.53365
CAV1 caveolin 1, caveolae protein, 22kDa 1.53327
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 1.5161
CEP85L centrosomal protein 85kDa-like 1.49916
PRR14 proline rich 14 1.49723
C9ORF3 chromosome 9 open reading frame 3 1.46277
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.45642
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 1.43914
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 1.40061
FNDC3B fibronectin type III domain containing 3B 1.35521
RFX4 regulatory factor X, 4 (influences HLA class II expression) 1.32793
CPNE8 copine VIII 1.29386
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.25917
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.1784
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 1.12851
FAM149B1 family with sequence similarity 149, member B1 1.12773
WNT8A wingless-type MMTV integration site family, member 8A 1.11203
PDE11A phosphodiesterase 11A 1.11203
TBX5 T-box 5 1.09783
CES1 carboxylesterase 1 1.08774
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.07729
CPNE5 copine V 1.05066
TMEM135 transmembrane protein 135 1.03592
PADI3 peptidyl arginine deiminase, type III 1.03536
SLC35F1 solute carrier family 35, member F1 1.01692
ACTN4 actinin, alpha 4 1.00059
ARHGAP24 Rho GTPase activating protein 24 1.00059
SCN10A sodium channel, voltage gated, type X alpha subunit 0.974864
CNTN5 contactin 5 0.971092
GIGYF1 GRB10 interacting GYF protein 1 0.96305
OSBP2 oxysterol binding protein 2 0.960972
GCH1 GTP cyclohydrolase 1 0.952906
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.947793
KIAA1715 KIAA1715 0.945838
CLCNKA chloride channel, voltage-sensitive Ka 0.931762
LRRC63 leucine rich repeat containing 63 0.919744
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.882984
DCP1A decapping mRNA 1A 0.882984
SMAD3 SMAD family member 3 0.870439
TMEM132D transmembrane protein 132D 0.855449
DAB2IP DAB2 interacting protein 0.855449
FABP7 fatty acid binding protein 7, brain 0.850223
CA10 carbonic anhydrase X 0.843198
EFNA5 ephrin-A5 0.841148
ARRB1 arrestin, beta 1 0.838165
PRKG1 protein kinase, cGMP-dependent, type I 0.82634
PITX2 paired-like homeodomain 2 0.825497
MAPK1 mitogen-activated protein kinase 1 0.823837
ZNF385D zinc finger protein 385D 0.816759
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.816759
DOCK4 dedicator of cytokinesis 4 0.808534
HPX hemopexin 0.807106
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.804323
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.798387
CHD6 chromodomain helicase DNA binding protein 6 0.787244
CMYA5 cardiomyopathy associated 5 0.785384
KIAA1549L KIAA1549-like 0.784773
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.782964
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.777754
NRG1 neuregulin 1 0.773909
IL12B interleukin 12B 0.772842
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.77023
TP73 tumor protein p73 0.767696
WDR86 WD repeat domain 86 0.767198
LGALS4 lectin, galactoside-binding, soluble, 4 0.766212
CNPY3 canopy FGF signaling regulator 3 0.765174
LDAH lipid droplet associated hydrolase 0.758275
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.755257
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.754273
NCEH1 neutral cholesterol ester hydrolase 1 0.744097
TK1 thymidine kinase 1, soluble 0.740245
PTK2 protein tyrosine kinase 2 0.739411
MYH11 myosin, heavy chain 11, smooth muscle 0.734094
MAP2 microtubule-associated protein 2 0.734094
ANKRD33B ankyrin repeat domain 33B 0.730636
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.728954
MBD5 methyl-CpG binding domain protein 5 0.728954
ZFPM2 zinc finger protein, FOG family member 2 0.721344
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.719817
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.712186
PARP12 poly (ADP-ribose) polymerase family, member 12 0.710458
VWA3B von Willebrand factor A domain containing 3B 0.692786
WBSCR17 Williams-Beuren syndrome chromosome region 17 0.689964
EBF1 early B-cell factor 1 0.689042
SLC38A8 solute carrier family 38, member 8 0.687825
CSMD1 CUB and Sushi multiple domains 1 0.686922
RALYL RALY RNA binding protein-like 0.686028
TENM4 teneurin transmembrane protein 4 0.685142
ELANE elastase, neutrophil expressed 0.681679
PRKCH protein kinase C, eta 0.679979
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.679359
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.679359
MCPH1 microcephalin 1 0.677522
APOA2 apolipoprotein A-II 0.676917
LAMA1 laminin, alpha 1 0.676316
DRD2 dopamine receptor D2 0.675718
KLHL21 kelch-like family member 21 0.674532
MTPN myotrophin 0.673945
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 0.670205
SEC31B SEC31 homolog B (S. cerevisiae) 0.667695
KLHL1 kelch-like family member 1 0.665514
ALK anaplastic lymphoma receptor tyrosine kinase 0.664442
TCF21 transcription factor 21 0.664442
TGFB2 transforming growth factor, beta 2 0.662854
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.652869
LINGO2 leucine rich repeat and Ig domain containing 2 0.652159
TMEM87B transmembrane protein 87B 0.652159
ITGA1 integrin, alpha 1 0.646866
NCOA1 nuclear receptor coactivator 1 0.644641
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.640327
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.638927
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.635958
ITGA9 integrin, alpha 9 0.635733
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.635061
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.634838
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.631765
RAB40C RAB40C, member RAS oncogene family 0.631549
EML6 echinoderm microtubule associated protein like 6 0.630262
ACTA2 actin, alpha 2, smooth muscle, aorta 0.627944
SGCZ sarcoglycan, zeta 0.62629
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.62426
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.621289
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.619932
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 0.6144
SSUH2 ssu-2 homolog (C. elegans) 0.611229
LAMB1 laminin, beta 1 0.60762
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.607443
FAS Fas cell surface death receptor 0.602605
TMEM232 transmembrane protein 232 0.595915
RNLS renalase, FAD-dependent amine oxidase 0.594349
ANTXR1 anthrax toxin receptor 1 0.592807
ZNF516 zinc finger protein 516 0.590688
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.588613
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.587592
CLMN calmin (calponin-like, transmembrane) 0.587592
CPQ carboxypeptidase Q 0.587158
NCALD neurocalcin delta 0.587014
TRIM67 tripartite motif containing 67 0.586295
OPCML opioid binding protein/cell adhesion molecule-like 0.583787
DLG2 discs, large homolog 2 (Drosophila) 0.583301
GRM5 glutamate receptor, metabotropic 5 0.58318
VAV3 vav 3 guanine nucleotide exchange factor 0.582338
ACYP2 acylphosphatase 2, muscle type 0.578934
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.578819
FAXC failed axon connections homolog (Drosophila) 0.57836
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.577337
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.577111
TUBA8 tubulin, alpha 8 0.572823
CHKB choline kinase beta 0.572823
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.556012
IDE insulin-degrading enzyme 0.556012
BTK Bruton agammaglobulinemia tyrosine kinase 0.55536
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.55536
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.539897
SPEG SPEG complex locus 0.535942
ADORA3 adenosine A3 receptor 0.53407
FLJ37453 uncharacterized LOC729614 0.520461
NPPA natriuretic peptide A 0.519375
CRYAB crystallin, alpha B 0.519375
GJA5 gap junction protein, alpha 5, 40kDa 0.516758
FGG fibrinogen gamma chain 0.516758
CENPO centromere protein O 0.514509
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.512008
TRAF1 TNF receptor-associated factor 1 0.507122
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.50495
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.50495
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.50495
IL1RAP interleukin 1 receptor accessory protein 0.502867
NACA nascent polypeptide-associated complex alpha subunit 0.502259
PRPF3 pre-mRNA processing factor 3 0.501459
NCKIPSD NCK interacting protein with SH3 domain 0.499816
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.498792
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.498792
NLRP12 NLR family, pyrin domain containing 12 0.494882
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.49303
RYR2 ryanodine receptor 2 (cardiac) 0.49303
BCL2 B-cell CLL/lymphoma 2 0.491241
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.489511
COPS5 COP9 signalosome subunit 5 0.487836
TGFBR3 transforming growth factor, beta receptor III 0.487836
KCTD10 potassium channel tetramerization domain containing 10 0.486163
PCSK6 proprotein convertase subtilisin/kexin type 6 0.484434
STARD3NL STARD3 N-terminal like 0.484434
ADGRV1 adhesion G protein-coupled receptor V1 0.481126
ACER3 alkaline ceramidase 3 0.481126
RNF157 ring finger protein 157 0.479543
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.479543
CLCN6 chloride channel, voltage-sensitive 6 0.476506
IP6K2 inositol hexakisphosphate kinase 2 0.475481
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.473207
MYOCD myocardin 0.470822
IL6R interleukin 6 receptor 0.469373
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.469373
PMVK phosphomevalonate kinase 0.467959
LIPA lipase A, lysosomal acid, cholesterol esterase 0.466578
ADRB3 adrenoceptor beta 3 0.466578
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.466578
UPB1 ureidopropionase, beta 0.466578
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.465228
CDKN2B-AS1 CDKN2B antisense RNA 1 0.463909
GHSR growth hormone secretagogue receptor 0.463909
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.46012
GAS7 growth arrest-specific 7 0.45891
PLXNA4 plexin A4 0.45891
MSI1 musashi RNA-binding protein 1 0.457258
CPA6 carboxypeptidase A6 0.454274
ACSM1 acyl-CoA synthetase medium-chain family member 1 0.453147
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.453147
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.450957
IGSF21 immunoglobin superfamily, member 21 0.447818
PPP4C protein phosphatase 4, catalytic subunit 0.445034
APOB apolipoprotein B 0.44484
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.443881
PCSK5 proprotein convertase subtilisin/kexin type 5 0.443881
LPAR1 lysophosphatidic acid receptor 1 0.443881
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.443881
NAE1 NEDD8 activating enzyme E1 subunit 1 0.437175
RUNX1 runt-related transcription factor 1 0.436375
MSH3 mutS homolog 3 0.435659
CABIN1 calcineurin binding protein 1 0.435659
TRIM55 tripartite motif containing 55 0.434952
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.434255
DEPTOR DEP domain containing MTOR-interacting protein 0.433568
NUCB2 nucleobindin 2 0.43289
COL4A1 collagen, type IV, alpha 1 0.43289
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.432689
PDE8A phosphodiesterase 8A 0.429632
TTN titin 0.429005
FOXO1 forkhead box O1 0.429005
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.427171
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.426575
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.426061
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.425664