sulfasalazine-6346 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the sulfasalazine-6346 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ADORA1 adenosine A1 receptor
AKAP7 A kinase (PRKA) anchor protein 7
ALDOB aldolase B, fructose-bisphosphate
AMT aminomethyltransferase
AP1M2 adaptor-related protein complex 1, mu 2 subunit
APOLD1 apolipoprotein L domain containing 1
ARID1A AT rich interactive domain 1A (SWI-like)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD5 ATPase family, AAA domain containing 5
C19ORF60 chromosome 19 open reading frame 60
C1ORF95 chromosome 1 open reading frame 95
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACTIN cactin, spliceosome C complex subunit
CD82 CD82 molecule
CPB2 carboxypeptidase B2 (plasma)
CSNK1E casein kinase 1, epsilon
CYB561 cytochrome b561
CYTH3 cytohesin 3
DMPK dystrophia myotonica-protein kinase
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNM3 dynamin 3
DVL2 dishevelled segment polarity protein 2
EDIL3 EGF-like repeats and discoidin I-like domains 3
EPOR erythropoietin receptor
ETV5 ets variant 5
EXD3 exonuclease 3'-5' domain containing 3
FGF5 fibroblast growth factor 5
FGF9 fibroblast growth factor 9
FLJ11292
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GATA3 GATA binding protein 3
GDAP1 ganglioside induced differentiation associated protein 1
GJA8 gap junction protein, alpha 8, 50kDa
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIC2 hypermethylated in cancer 2
HIST1H4E histone cluster 1, H4e
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IFI44L interferon-induced protein 44-like
IL5RA interleukin 5 receptor, alpha
INCENP inner centromere protein antigens 135/155kDa
INO80B INO80 complex subunit B
ITPKA inositol-trisphosphate 3-kinase A
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KRT34 keratin 34, type I
LOC257152 uncharacterized LOC257152
LPAR4 lysophosphatidic acid receptor 4
LTC4S leukotriene C4 synthase
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAGEA12 melanoma antigen family A12
MB myoglobin
MBNL3 muscleblind-like splicing regulator 3
MEG3 maternally expressed 3 (non-protein coding)
MFN2 mitofusin 2
MINK1 misshapen-like kinase 1
NAG18 NAG18 mRNA
NDNF neuron-derived neurotrophic factor
NDRG2 NDRG family member 2
NEU3 sialidase 3 (membrane sialidase)
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFIB nuclear factor I/B
NKTR natural killer cell triggering receptor
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCDH1 protocadherin 1
PCDHGB5 protocadherin gamma subfamily B, 5
PCNX pecanex homolog (Drosophila)
PDGFB platelet-derived growth factor beta polypeptide
PEX16 peroxisomal biogenesis factor 16
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PNMA2 paraneoplastic Ma antigen 2
POU2F2 POU class 2 homeobox 2
PRDX2 peroxiredoxin 2
PRSS16 protease, serine, 16 (thymus)
RGS12 regulator of G-protein signaling 12
RPH3AL rabphilin 3A-like (without C2 domains)
RPS3A ribosomal protein S3A
SAYSD1 SAYSVFN motif domain containing 1
SCD5 stearoyl-CoA desaturase 5
SCEL sciellin
SCIN scinderin
SCN3B sodium channel, voltage gated, type III beta subunit
SMAD6 SMAD family member 6
SSTR4 somatostatin receptor 4
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STARD3 StAR-related lipid transfer (START) domain containing 3
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBC1D17 TBC1 domain family, member 17
TBX1 T-box 1
TCP11L1 t-complex 11, testis-specific-like 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBGCP2 tubulin, gamma complex associated protein 2
UNC119 unc-119 homolog (C. elegans)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
XAF1 XIAP associated factor 1
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
APLP1 amyloid beta (A4) precursor-like protein 1
ARMC7 armadillo repeat containing 7
BATF3 basic leucine zipper transcription factor, ATF-like 3
C11ORF63 chromosome 11 open reading frame 63
C1ORF159 chromosome 1 open reading frame 159
CCDC25 coiled-coil domain containing 25
CDC37L1 cell division cycle 37-like 1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CTSF cathepsin F
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ETNK2 ethanolamine kinase 2
EXOC5 exocyst complex component 5
FADS2 fatty acid desaturase 2
FAM186A family with sequence similarity 186, member A
FBXL7 F-box and leucine-rich repeat protein 7
FUZ fuzzy planar cell polarity protein
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GLDC glycine dehydrogenase (decarboxylating)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GTF2I general transcription factor IIi
HDAC5 histone deacetylase 5
HIST1H2AG histone cluster 1, H2ag
HIST1H3G histone cluster 1, H3g
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IFT46 intraflagellar transport 46
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
JUNB jun B proto-oncogene
KIFC1 kinesin family member C1
KRI1 KRI1 homolog (S. cerevisiae)
LINC00341 long intergenic non-protein coding RNA 341
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAGEF1 melanoma antigen family F1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MOSPD3 motile sperm domain containing 3
MOXD1 monooxygenase, DBH-like 1
MRPL41 mitochondrial ribosomal protein L41
MUC3B mucin 3B, cell surface associated
MYO1D myosin ID
MYO1E myosin IE
NDRG4 NDRG family member 4
NLRX1 NLR family member X1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OVGP1 oviductal glycoprotein 1, 120kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDE12 phosphodiesterase 12
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POMT2 protein-O-mannosyltransferase 2
POR P450 (cytochrome) oxidoreductase
POTEKP POTE ankyrin domain family, member K, pseudogene
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PTCD2 pentatricopeptide repeat domain 2
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAB33B RAB33B, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RNF146 ring finger protein 146
RPAP1 RNA polymerase II associated protein 1
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
S100A14 S100 calcium binding protein A14
SDC3 syndecan 3
SERTAD3 SERTA domain containing 3
SHROOM2 shroom family member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A40 solute carrier family 25, member 40
SLC35G2 solute carrier family 35, member G2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYTL2 synaptotagmin-like 2
TBC1D10B TBC1 domain family, member 10B
TCTA T-cell leukemia translocation altered
TEX40 testis expressed 40
TMEM121 transmembrane protein 121
TMEM183A transmembrane protein 183A
TMEM57 transmembrane protein 57
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNS2 tensin 2
TRAIP TRAF interacting protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN8 tetraspanin 8
URM1 ubiquitin related modifier 1
USP21 ubiquitin specific peptidase 21
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZFHX3 zinc finger homeobox 3
ZNF215 zinc finger protein 215
ZNF254 zinc finger protein 254