sulfasalazine-2882 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the sulfasalazine-2882 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ALAS2 5'-aminolevulinate synthase 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASIC1 acid sensing (proton gated) ion channel 1
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
BARX2 BARX homeobox 2
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCORL1 BCL6 corepressor-like 1
BTG2 BTG family, member 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C19ORF66 chromosome 19 open reading frame 66
C21ORF2 chromosome 21 open reading frame 2
C2ORF68 chromosome 2 open reading frame 68
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCNJL cyclin J-like
CD82 CD82 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP152 centrosomal protein 152kDa
CLCA3P chloride channel accessory 3, pseudogene
CNGB3 cyclic nucleotide gated channel beta 3
CNN1 calponin 1, basic, smooth muscle
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEPDC5 DEP domain containing 5
DHRS12 dehydrogenase/reductase (SDR family) member 12
DLX2 distal-less homeobox 2
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EFNB3 ephrin-B3
EMID1 EMI domain containing 1
ERCC2 excision repair cross-complementation group 2
ERP44 endoplasmic reticulum protein 44
FAM174B family with sequence similarity 174, member B
FBXL15 F-box and leucine-rich repeat protein 15
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FFAR3 free fatty acid receptor 3
FOXE1 forkhead box E1
FSCN1 fascin actin-bundling protein 1
GSTTP1 glutathione S-transferase theta pseudogene 1
HLF hepatic leukemia factor
HNF1B HNF1 homeobox B
HNRNPM heterogeneous nuclear ribonucleoprotein M
HOPX HOP homeobox
HRASLS2 HRAS-like suppressor 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIAA1024 KIAA1024
KLHL25 kelch-like family member 25
KRT16 keratin 16, type I
LINC00597 long intergenic non-protein coding RNA 597
MBD3 methyl-CpG binding domain protein 3
MCTP2 multiple C2 domains, transmembrane 2
MRPL41 mitochondrial ribosomal protein L41
MST1 macrophage stimulating 1
MYH14 myosin, heavy chain 14, non-muscle
NF1 neurofibromin 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTF3 neurotrophin 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUMA1 nuclear mitotic apparatus protein 1
NYX nyctalopin
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSBPL10 oxysterol binding protein-like 10
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDE10A phosphodiesterase 10A
PHF20L1 PHD finger protein 20-like 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRKCB protein kinase C, beta
PSG1 pregnancy specific beta-1-glycoprotein 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RABEP2 rabaptin, RAB GTPase binding effector protein 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RUNX1 runt-related transcription factor 1
SARM1 sterile alpha and TIR motif containing 1
SDS serine dehydratase
SETBP1 SET binding protein 1
SFTPB surfactant protein B
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMC1A structural maintenance of chromosomes 1A
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX29P2 sorting nexin 29 pseudogene 2
SOAT2 sterol O-acyltransferase 2
SOX2 SRY (sex determining region Y)-box 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK5 serine peptidase inhibitor, Kazal type 5
STIM1 stromal interaction molecule 1
STK38L serine/threonine kinase 38 like
STOML1 stomatin (EPB72)-like 1
TAPBP TAP binding protein (tapasin)
TAPBPL TAP binding protein-like
TBKBP1 TBK1 binding protein 1
TCEAL2 transcription elongation factor A (SII)-like 2
TMLHE trimethyllysine hydroxylase, epsilon
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
VAV2 vav 2 guanine nucleotide exchange factor
ZFHX4 zinc finger homeobox 4
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
ACTL8 actin-like 8
ADCY7 adenylate cyclase 7
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARMC4 armadillo repeat containing 4
BCAS1 breast carcinoma amplified sequence 1
BCL2L2 BCL2-like 2
C14ORF79 chromosome 14 open reading frame 79
C19ORF73 chromosome 19 open reading frame 73
C2ORF54 chromosome 2 open reading frame 54
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC68 coiled-coil domain containing 68
CD8A CD8a molecule
CDK3 cyclin-dependent kinase 3
CORO7 coronin 7
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRYBG3 beta-gamma crystallin domain containing 3
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDAR ectodysplasin A receptor
ERCC4 excision repair cross-complementation group 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM110B family with sequence similarity 110, member B
FAM169A family with sequence similarity 169, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF23 fibroblast growth factor 23
FLCN folliculin
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH3 G patch domain containing 3
HIST1H3B histone cluster 1, H3b
HOXC10 homeobox C10
HOXC4 homeobox C4
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFT140 intraflagellar transport 140
IGSF1 immunoglobulin superfamily, member 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA0754 KIAA0754
KLHL36 kelch-like family member 36
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KREMEN2 kringle containing transmembrane protein 2
LAMB3 laminin, beta 3
LOC729164 hCG1732469
LRP2 low density lipoprotein receptor-related protein 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LZTR1 leucine-zipper-like transcription regulator 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAST3 microtubule associated serine/threonine kinase 3
MBTD1 mbt domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MT1H metallothionein 1H
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NOL10 nucleolar protein 10
NXPE3 neurexophilin and PC-esterase domain family, member 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
ORAI3 ORAI calcium release-activated calcium modulator 3
PEX26 peroxisomal biogenesis factor 26
PHF14 PHD finger protein 14
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PITX2 paired-like homeodomain 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLXNA3 plexin A3
POMT2 protein-O-mannosyltransferase 2
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RASL11B RAS-like, family 11, member B
RLN1 relaxin 1
RPL10L ribosomal protein L10-like
SCML2 sex comb on midleg-like 2 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SECTM1 secreted and transmembrane 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHARPIN SHANK-associated RH domain interactor
SIK1 salt-inducible kinase 1
SIRT6 sirtuin 6
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A40 solute carrier family 25, member 40
SRD5A3 steroid 5 alpha-reductase 3
TAOK1 TAO kinase 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TH tyrosine hydroxylase
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TRIM21 tripartite motif containing 21
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTBK2 tau tubulin kinase 2
UNC119 unc-119 homolog (C. elegans)
WDR33 WD repeat domain 33
WDR76 WD repeat domain 76
WDR91 WD repeat domain 91
WWC2 WW and C2 domain containing 2
XAB2 XPA binding protein 2
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB48 zinc finger and BTB domain containing 48
ZNF606 zinc finger protein 606
ZNF639 zinc finger protein 639
ZNF665 zinc finger protein 665
ZSCAN31 zinc finger and SCAN domain containing 31