sulfamethoxypyridazine-4733 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the sulfamethoxypyridazine-4733 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALOX15B arachidonate 15-lipoxygenase, type B
ANGPT4 angiopoietin 4
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANXA2P1 annexin A2 pseudogene 1
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BTN3A3 butyrophilin, subfamily 3, member A3
CCL19 chemokine (C-C motif) ligand 19
CCL21 chemokine (C-C motif) ligand 21
CCL27 chemokine (C-C motif) ligand 27
CCR7 chemokine (C-C motif) receptor 7
CD28 CD28 molecule
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLTA clathrin, light chain A
CNTN1 contactin 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COMP cartilage oligomeric matrix protein
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
DKKL1 dickkopf-like 1
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DPYS dihydropyrimidinase
DSPP dentin sialophosphoprotein
DTX2 deltex 2, E3 ubiquitin ligase
EDA ectodysplasin A
EPAS1 endothelial PAS domain protein 1
FGB fibrinogen beta chain
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GRIK5 glutamate receptor, ionotropic, kainate 5
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H3C histone cluster 1, H3c
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXB9 homeobox B9
HOXD13 homeobox D13
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IBSP integrin-binding sialoprotein
IFNA14 interferon, alpha 14
IGHM immunoglobulin heavy constant mu
IGSF6 immunoglobulin superfamily, member 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1RN interleukin 1 receptor antagonist
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KIF1C kinesin family member 1C
LOC100127972 uncharacterized LOC100127972
LOX lysyl oxidase
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MALL mal, T-cell differentiation protein-like
MEF2D myocyte enhancer factor 2D
METTL7A methyltransferase like 7A
MIR622 microRNA 622
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MR1 major histocompatibility complex, class I-related
MRAS muscle RAS oncogene homolog
MSR1 macrophage scavenger receptor 1
MTSS1L metastasis suppressor 1-like
MYT1 myelin transcription factor 1
NAG18 NAG18 mRNA
NIPAL3 NIPA-like domain containing 3
NRF1 nuclear respiratory factor 1
NRG1 neuregulin 1
OGG1 8-oxoguanine DNA glycosylase
PCDHGB6 protocadherin gamma subfamily B, 6
PDE4DIP phosphodiesterase 4D interacting protein
POM121L2 POM121 transmembrane nucleoporin-like 2
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRKCA protein kinase C, alpha
PTHLH parathyroid hormone-like hormone
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGS12 regulator of G-protein signaling 12
RGS4 regulator of G-protein signaling 4
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RPL35A ribosomal protein L35a
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETBP1 SET binding protein 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIGLEC8 sialic acid binding Ig-like lectin 8
SNRK SNF related kinase
SPAG8 sperm associated antigen 8
SPRR1A small proline-rich protein 1A
SRPX2 sushi-repeat containing protein, X-linked 2
SRSF7 serine/arginine-rich splicing factor 7
SSX1 synovial sarcoma, X breakpoint 1
SSX3 synovial sarcoma, X breakpoint 3
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCP10 t-complex 10
TCP11L1 t-complex 11, testis-specific-like 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAC T cell receptor alpha constant
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
VCAN versican
XDH xanthine dehydrogenase

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACSL4 acyl-CoA synthetase long-chain family member 4
ADGRG2 adhesion G protein-coupled receptor G2
AGMAT agmatine ureohydrolase (agmatinase)
ARL15 ADP-ribosylation factor-like 15
BGLAP bone gamma-carboxyglutamate (gla) protein
C6ORF47 chromosome 6 open reading frame 47
CAMK1 calcium/calmodulin-dependent protein kinase I
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC6 coiled-coil domain containing 6
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CD82 CD82 molecule
CDK20 cyclin-dependent kinase 20
CES3 carboxylesterase 3
CLCN5 chloride channel, voltage-sensitive 5
CRYBG3 beta-gamma crystallin domain containing 3
CST6 cystatin E/M
CUZD1 CUB and zona pellucida-like domains 1
DENND4A DENN/MADD domain containing 4A
DHDDS dehydrodolichyl diphosphate synthase
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
ELP6 elongator acetyltransferase complex subunit 6
EPHX2 epoxide hydrolase 2, cytoplasmic
F2R coagulation factor II (thrombin) receptor
FAM189A2 family with sequence similarity 189, member A2
FOXC1 forkhead box C1
GBP2 guanylate binding protein 2, interferon-inducible
GID4 GID complex subunit 4
GPALPP1 GPALPP motifs containing 1
HAMP hepcidin antimicrobial peptide
HAUS6 HAUS augmin-like complex, subunit 6
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HMHA1 histocompatibility (minor) HA-1
HMOX1 heme oxygenase 1
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPA1L heat shock 70kDa protein 1-like
IFI6 interferon, alpha-inducible protein 6
IFNAR1 interferon (alpha, beta and omega) receptor 1
INPP1 inositol polyphosphate-1-phosphatase
KITLG KIT ligand
KPNA5 karyopherin alpha 5 (importin alpha 6)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP2 latent transforming growth factor beta binding protein 2
MANBA mannosidase, beta A, lysosomal
MBTPS2 membrane-bound transcription factor peptidase, site 2
MDM4 MDM4, p53 regulator
MTCP1 mature T-cell proliferation 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPFFR1 neuropeptide FF receptor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1D2 nuclear receptor subfamily 1, group D, member 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCDHB8 protocadherin beta 8
PER3 period circadian clock 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRF1 perforin 1 (pore forming protein)
PRSS53 protease, serine, 53
PTK6 protein tyrosine kinase 6
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
QSER1 glutamine and serine rich 1
RAD51AP1 RAD51 associated protein 1
RPL13P5 ribosomal protein L13 pseudogene 5
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRAGB Ras-related GTP binding B
SCYL2 SCY1-like 2 (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETD8 SET domain containing (lysine methyltransferase) 8
SIX1 SIX homeobox 1
SLC12A8 solute carrier family 12, member 8
SMAD5 SMAD family member 5
SNX16 sorting nexin 16
SPRYD7 SPRY domain containing 7
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM38B transmembrane protein 38B
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIM25 tripartite motif containing 25
TUBA3C tubulin, alpha 3c
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
ZBTB44 zinc finger and BTB domain containing 44
ZBTB48 zinc finger and BTB domain containing 48
ZBTB6 zinc finger and BTB domain containing 6
ZNF134 zinc finger protein 134
ZNF16 zinc finger protein 16
ZNF253 zinc finger protein 253
ZNF35 zinc finger protein 35
ZNF551 zinc finger protein 551
ZNF675 zinc finger protein 675
ZNF816 zinc finger protein 816