sulfamethoxypyridazine-3711 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the sulfamethoxypyridazine-3711 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
BAGE B melanoma antigen
BMP7 bone morphogenetic protein 7
BST1 bone marrow stromal cell antigen 1
BTF3P11 basic transcription factor 3 pseudogene 11
CALCB calcitonin-related polypeptide beta
CCDC30 coiled-coil domain containing 30
CCDC57 coiled-coil domain containing 57
CD5 CD5 molecule
CD86 CD86 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CELA2B chymotrypsin-like elastase family, member 2B
CEP152 centrosomal protein 152kDa
CGA glycoprotein hormones, alpha polypeptide
CLEC4M C-type lectin domain family 4, member M
CLTA clathrin, light chain A
COPZ2 coatomer protein complex, subunit zeta 2
DACH1 dachshund family transcription factor 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DHRS12 dehydrogenase/reductase (SDR family) member 12
DMC1 DNA meiotic recombinase 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
EML3 echinoderm microtubule associated protein like 3
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAM189A1 family with sequence similarity 189, member A1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAS7 growth arrest-specific 7
GGTLC1 gamma-glutamyltransferase light chain 1
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR15 G protein-coupled receptor 15
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM2 glutamate receptor, metabotropic 2
HFE hemochromatosis
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNF4A hepatocyte nuclear factor 4, alpha
IGFBP7 insulin-like growth factor binding protein 7
IHH indian hedgehog
IL19 interleukin 19
IL22RA1 interleukin 22 receptor, alpha 1
IQGAP2 IQ motif containing GTPase activating protein 2
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
LBH limb bud and heart development
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTBP4 latent transforming growth factor beta binding protein 4
MAP7D3 MAP7 domain containing 3
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD7 major facilitator superfamily domain containing 7
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MMP13 matrix metallopeptidase 13
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MYOZ1 myozenin 1
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEUROD4 neuronal differentiation 4
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NMRK2 nicotinamide riboside kinase 2
NPPA natriuretic peptide A
NPTXR neuronal pentraxin receptor
NR6A1 nuclear receptor subfamily 6, group A, member 1
PDE4DIP phosphodiesterase 4D interacting protein
PDIA2 protein disulfide isomerase family A, member 2
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PRB1 proline-rich protein BstNI subfamily 1
PRDX2 peroxiredoxin 2
PROL1 proline rich, lacrimal 1
PTAFR platelet-activating factor receptor
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
REC8 REC8 meiotic recombination protein
RECQL5 RecQ protein-like 5
RPL18 ribosomal protein L18
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SPAG8 sperm associated antigen 8
SPINK5 serine peptidase inhibitor, Kazal type 5
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SSTR5 somatostatin receptor 5
TEX14 testis expressed 14
TJAP1 tight junction associated protein 1 (peripheral)
TMEM176A transmembrane protein 176A
TRD T cell receptor delta locus
TRIM29 tripartite motif containing 29
TSHR thyroid stimulating hormone receptor
TUBA3C tubulin, alpha 3c
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L1 ZFP36 ring finger protein-like 1
ZIC3 Zic family member 3

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACOT8 acyl-CoA thioesterase 8
ADAP2 ArfGAP with dual PH domains 2
ADCY6 adenylate cyclase 6
ADTRP androgen-dependent TFPI-regulating protein
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ANG angiogenin, ribonuclease, RNase A family, 5
ANKH ANKH inorganic pyrophosphate transport regulator
ARHGAP24 Rho GTPase activating protein 24
ARL14 ADP-ribosylation factor-like 14
BAHCC1 BAH domain and coiled-coil containing 1
BDKRB1 bradykinin receptor B1
BICC1 BicC family RNA binding protein 1
C16ORF62 chromosome 16 open reading frame 62
C5 complement component 5
C7ORF43 chromosome 7 open reading frame 43
C9ORF40 chromosome 9 open reading frame 40
CDON cell adhesion associated, oncogene regulated
CDT1 chromatin licensing and DNA replication factor 1
CEP295 centrosomal protein 295kDa
CES3 carboxylesterase 3
CHST10 carbohydrate sulfotransferase 10
CLIC3 chloride intracellular channel 3
CORO2A coronin, actin binding protein, 2A
CPED1 cadherin-like and PC-esterase domain containing 1
CPNE7 copine VII
CYBRD1 cytochrome b reductase 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DENND2D DENN/MADD domain containing 2D
DIO3 deiodinase, iodothyronine, type III
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAL4 dynein, axonemal, light chain 4
DSPP dentin sialophosphoprotein
EDN1 endothelin 1
EFNA3 ephrin-A3
EML4 echinoderm microtubule associated protein like 4
EPHX2 epoxide hydrolase 2, cytoplasmic
FAM120C family with sequence similarity 120C
FAM204A family with sequence similarity 204, member A
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRTP1 growth hormone regulated TBC protein 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HOXA1 homeobox A1
HOXB9 homeobox B9
HSPA1L heat shock 70kDa protein 1-like
IDI2-AS1 IDI2 antisense RNA 1
IL22 interleukin 22
IL33 interleukin 33
KCTD17 potassium channel tetramerization domain containing 17
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LMO7 LIM domain 7
LPPR4 lipid phosphate phosphatase-related protein type 4
MBD5 methyl-CpG binding domain protein 5
MRPL44 mitochondrial ribosomal protein L44
MT1M metallothionein 1M
MTA2 metastasis associated 1 family, member 2
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAT6 N-acetyltransferase 6 (GCN5-related)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NLK nemo-like kinase
NPFFR1 neuropeptide FF receptor 1
NTSR1 neurotensin receptor 1 (high affinity)
OGDHL oxoglutarate dehydrogenase-like
PICK1 protein interacting with PRKCA 1
PLD3 phospholipase D family, member 3
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRR3 proline rich 3
PTPRS protein tyrosine phosphatase, receptor type, S
RARS arginyl-tRNA synthetase
RPA4 replication protein A4, 30kDa
SAMD9 sterile alpha motif domain containing 9
SCEL sciellin
SCML2 sex comb on midleg-like 2 (Drosophila)
SENP7 SUMO1/sentrin specific peptidase 7
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC46A3 solute carrier family 46, member 3
SREK1IP1 SREK1-interacting protein 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D30 TBC1 domain family, member 30
TMC7 transmembrane channel-like 7
TMCC2 transmembrane and coiled-coil domain family 2
TMEM180 transmembrane protein 180
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TXK TXK tyrosine kinase
UBTD1 ubiquitin domain containing 1
VEZT vezatin, adherens junctions transmembrane protein
VN1R1 vomeronasal 1 receptor 1
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF286A zinc finger protein 286A
ZNF639 zinc finger protein 639
ZNF702P zinc finger protein 702, pseudogene