sulfamethoxazole-3667 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the sulfamethoxazole-3667 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACO2 aconitase 2, mitochondrial
ACSM1 acyl-CoA synthetase medium-chain family member 1
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADAM22 ADAM metallopeptidase domain 22
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AGFG1 ArfGAP with FG repeats 1
ANXA10 annexin A10
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APP amyloid beta (A4) precursor protein
ARMC4 armadillo repeat containing 4
ARSA arylsulfatase A
ASCL1 achaete-scute family bHLH transcription factor 1
BBC3 BCL2 binding component 3
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BMP10 bone morphogenetic protein 10
CACNG5 calcium channel, voltage-dependent, gamma subunit 5
CALML3 calmodulin-like 3
CCDC144A coiled-coil domain containing 144A
CD200 CD200 molecule
CD58 CD58 molecule
CDC14A cell division cycle 14A
CDRT1 CMT1A duplicated region transcript 1
CFAP70 cilia and flagella associated protein 70
CHAT choline O-acetyltransferase
CLDN17 claudin 17
CNGB3 cyclic nucleotide gated channel beta 3
COL2A1 collagen, type II, alpha 1
CPB2 carboxypeptidase B2 (plasma)
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DKFZP434L187 uncharacterized LOC26082
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGR1 early growth response 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM174B family with sequence similarity 174, member B
FILIP1L filamin A interacting protein 1-like
FKBP10 FK506 binding protein 10, 65 kDa
FNDC4 fibronectin type III domain containing 4
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HAMP hepcidin antimicrobial peptide
HIST1H3F histone cluster 1, H3f
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
ICOSLG inducible T-cell co-stimulator ligand
IFFO1 intermediate filament family orphan 1
IGFBP7 insulin-like growth factor binding protein 7
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KIF25 kinesin family member 25
KLK13 kallikrein-related peptidase 13
KSR1 kinase suppressor of ras 1
LECT1 leukocyte cell derived chemotaxin 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LILRP2 leukocyte immunoglobulin-like receptor pseudogene 2
LIMK1 LIM domain kinase 1
LOC284244 uncharacterized LOC284244
LRRN2 leucine rich repeat neuronal 2
MBD2 methyl-CpG binding domain protein 2
MEGF6 multiple EGF-like-domains 6
MUC3B mucin 3B, cell surface associated
NCR2 natural cytotoxicity triggering receptor 2
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLGN1 neuroligin 1
NOD2 nucleotide-binding oligomerization domain containing 2
NPFF neuropeptide FF-amide peptide precursor
NPM3 nucleophosmin/nucleoplasmin 3
NRN1 neuritin 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OR2C1 olfactory receptor, family 2, subfamily C, member 1
PAX3 paired box 3
PBX1 pre-B-cell leukemia homeobox 1
PBX2 pre-B-cell leukemia homeobox 2
PCDHB13 protocadherin beta 13
PCDHB3 protocadherin beta 3
PIGR polymeric immunoglobulin receptor
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLA2G5 phospholipase A2, group V
PLEK pleckstrin
PLP1 proteolipid protein 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTAFR platelet-activating factor receptor
PYY peptide YY
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAVER2 ribonucleoprotein, PTB-binding 2
RBM48 RNA binding motif protein 48
SIGLEC8 sialic acid binding Ig-like lectin 8
SLAMF7 SLAM family member 7
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAT tyrosine aminotransferase
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TSC22D2 TSC22 domain family, member 2
TSPAN9 tetraspanin 9
TTC38 tetratricopeptide repeat domain 38
WTAP Wilms tumor 1 associated protein
ZMAT4 zinc finger, matrin-type 4

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ADTRP androgen-dependent TFPI-regulating protein
AGMAT agmatine ureohydrolase (agmatinase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BDKRB1 bradykinin receptor B1
C17ORF53 chromosome 17 open reading frame 53
C17ORF80 chromosome 17 open reading frame 80
C4ORF29 chromosome 4 open reading frame 29
CCDC85C coiled-coil domain containing 85C
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
COBL cordon-bleu WH2 repeat protein
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CRY2 cryptochrome circadian clock 2
CTAGE9 CTAGE family, member 9
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
DENND5B DENN/MADD domain containing 5B
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
EFNA3 ephrin-A3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EXOC5 exocyst complex component 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLCN folliculin
FNTB farnesyltransferase, CAAX box, beta
FZD8 frizzled class receptor 8
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLB1L galactosidase, beta 1-like
GMEB1 glucocorticoid modulatory element binding protein 1
GPR176 G protein-coupled receptor 176
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
IFI6 interferon, alpha-inducible protein 6
IL6 interleukin 6
IL7 interleukin 7
IRAK4 interleukin-1 receptor-associated kinase 4
IREB2 iron-responsive element binding protein 2
KLHL36 kelch-like family member 36
KRT4 keratin 4, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIG4 ligase IV, DNA, ATP-dependent
LINC00260 long intergenic non-protein coding RNA 260
LRRC37A3 leucine rich repeat containing 37, member A3
MAGEF1 melanoma antigen family F1
METTL16 methyltransferase like 16
MPI mannose phosphate isomerase
NEK11 NIMA-related kinase 11
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPFFR1 neuropeptide FF receptor 1
NR3C2 nuclear receptor subfamily 3, group C, member 2
NXPE3 neurexophilin and PC-esterase domain family, member 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PARD6A par-6 family cell polarity regulator alpha
PARP3 poly (ADP-ribose) polymerase family, member 3
PCOLCE procollagen C-endopeptidase enhancer
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTK6 protein tyrosine kinase 6
RARS arginyl-tRNA synthetase
RNF122 ring finger protein 122
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCAI suppressor of cancer cell invasion
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMO smoothened, frizzled class receptor
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYTL2 synaptotagmin-like 2
TEX40 testis expressed 40
TFCP2L1 transcription factor CP2-like 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM230 transmembrane protein 230
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TSPYL5 TSPY-like 5
UGT8 UDP glycosyltransferase 8
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR76 WD repeat domain 76
WFDC2 WAP four-disulfide core domain 2
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF197 zinc finger protein 197
ZNF264 zinc finger protein 264
ZNF426 zinc finger protein 426
ZNF510 zinc finger protein 510
ZNF652 zinc finger protein 652
ZNF667 zinc finger protein 667
ZNF721 zinc finger protein 721
ZNF749 zinc finger protein 749
ZNF91 zinc finger protein 91
ZW10 zw10 kinetochore protein