sulfadoxine-3547 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the sulfadoxine-3547 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACO2 aconitase 2, mitochondrial
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADAM2 ADAM metallopeptidase domain 2
AHSP alpha hemoglobin stabilizing protein
AP3B2 adaptor-related protein complex 3, beta 2 subunit
APOL2 apolipoprotein L, 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
AREG amphiregulin
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
C21ORF2 chromosome 21 open reading frame 2
CCDC71 coiled-coil domain containing 71
CCP110 centriolar coiled coil protein 110kDa
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLEC3B C-type lectin domain family 3, member B
CNN1 calponin 1, basic, smooth muscle
CNTNAP1 contactin associated protein 1
CRABP1 cellular retinoic acid binding protein 1
CRHR2 corticotropin releasing hormone receptor 2
CXORF21 chromosome X open reading frame 21
CYLD cylindromatosis (turban tumor syndrome)
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DCAF15 DDB1 and CUL4 associated factor 15
DDO D-aspartate oxidase
DGCR6L DiGeorge syndrome critical region gene 6-like
DNASE2B deoxyribonuclease II beta
DUOX1 dual oxidase 1
EFNA3 ephrin-A3
EGFR epidermal growth factor receptor
EHD2 EH-domain containing 2
FAM46C family with sequence similarity 46, member C
FBXO21 F-box protein 21
FBXO4 F-box protein 4
FLJ11292
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GIF gastric intrinsic factor (vitamin B synthesis)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPR161 G protein-coupled receptor 161
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA1 high mobility group AT-hook 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL11 interleukin 11
IL6ST interleukin 6 signal transducer
INPP5J inositol polyphosphate-5-phosphatase J
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LARP7 La ribonucleoprotein domain family, member 7
LGALS4 lectin, galactoside-binding, soluble, 4
LRRC75B leucine rich repeat containing 75B
MAGEA12 melanoma antigen family A12
MCTP2 multiple C2 domains, transmembrane 2
MTCP1 mature T-cell proliferation 1
MUC2 mucin 2, oligomeric mucus/gel-forming
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NIPAL3 NIPA-like domain containing 3
NKX3-2 NK3 homeobox 2
NPTX1 neuronal pentraxin I
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OSMR oncostatin M receptor
PDE4C phosphodiesterase 4C, cAMP-specific
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKD2L2 polycystic kidney disease 2-like 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAUR plasminogen activator, urokinase receptor
PLCG1 phospholipase C, gamma 1
PLIN2 perilipin 2
PMP2 peripheral myelin protein 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKCA protein kinase C, alpha
PTPRB protein tyrosine phosphatase, receptor type, B
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOBTB2 Rho-related BTB domain containing 2
RNF31 ring finger protein 31
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAYSD1 SAYSVFN motif domain containing 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLIT2 slit homolog 2 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D17 TBC1 domain family, member 17
TFEB transcription factor EB
TM4SF4 transmembrane 4 L six family member 4
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPMT thiopurine S-methyltransferase
TSC22D4 TSC22 domain family, member 4
TSHR thyroid stimulating hormone receptor
VCAN versican
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
ZFHX2 zinc finger homeobox 2
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTL8 actin-like 8
ADAM15 ADAM metallopeptidase domain 15
AHDC1 AT hook, DNA binding motif, containing 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ANKRD40 ankyrin repeat domain 40
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARRB1 arrestin, beta 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCNK cyclin K
CD82 CD82 molecule
CD83 CD83 molecule
CHPF chondroitin polymerizing factor
CISH cytokine inducible SH2-containing protein
CNGB3 cyclic nucleotide gated channel beta 3
CSTA cystatin A (stefin A)
DCAF13 DDB1 and CUL4 associated factor 13
DCAF16 DDB1 and CUL4 associated factor 16
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EXD3 exonuclease 3'-5' domain containing 3
FBXW12 F-box and WD repeat domain containing 12
GAB2 GRB2-associated binding protein 2
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLCE glucuronic acid epimerase
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNL1 guanine nucleotide binding protein-like 1
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HEATR3 HEAT repeat containing 3
HIST1H4F histone cluster 1, H4f
HIST2H2AA3 histone cluster 2, H2aa3
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HYI hydroxypyruvate isomerase (putative)
IFT140 intraflagellar transport 140
INCENP inner centromere protein antigens 135/155kDa
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCTD7 potassium channel tetramerization domain containing 7
KIFC1 kinesin family member C1
KLF3 Kruppel-like factor 3 (basic)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHX1 LIM homeobox 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MAGEA3 melanoma antigen family A3
METTL16 methyltransferase like 16
MTG1 mitochondrial ribosome-associated GTPase 1
MYO19 myosin XIX
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PACS1 phosphofurin acidic cluster sorting protein 1
PC pyruvate carboxylase
PCDHA9 protocadherin alpha 9
PCDHB8 protocadherin beta 8
PDIA3 protein disulfide isomerase family A, member 3
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
RBM42 RNA binding motif protein 42
REEP4 receptor accessory protein 4
RPGR retinitis pigmentosa GTPase regulator
SCAI suppressor of cancer cell invasion
SH2D4A SH2 domain containing 4A
SIX1 SIX homeobox 1
SLC12A8 solute carrier family 12, member 8
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNUPN snurportin 1
SPRYD7 SPRY domain containing 7
SREBF2 sterol regulatory element binding transcription factor 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUN2 Sad1 and UNC84 domain containing 2
TAOK1 TAO kinase 1
TET3 tet methylcytosine dioxygenase 3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM159 transmembrane protein 159
TMEM209 transmembrane protein 209
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TSPO translocator protein (18kDa)
TUBA3C tubulin, alpha 3c
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP36 ubiquitin specific peptidase 36
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR91 WD repeat domain 91
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF324 zinc finger protein 324
ZNF428 zinc finger protein 428
ZNF516 zinc finger protein 516
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF669 zinc finger protein 669
ZNF675 zinc finger protein 675
ZNF91 zinc finger protein 91