sulfachlorpyridazine-4326 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the sulfachlorpyridazine-4326 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADAM28 ADAM metallopeptidase domain 28
ADAMTSL4 ADAMTS-like 4
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AK5 adenylate kinase 5
AMACR alpha-methylacyl-CoA racemase
ANKH ANKH inorganic pyrophosphate transport regulator
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP6 aquaporin 6, kidney specific
ARTN artemin
C10ORF12 chromosome 10 open reading frame 12
CD33 CD33 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC4E C-type lectin domain family 4, member E
COL11A1 collagen, type XI, alpha 1
CPZ carboxypeptidase Z
CRTC1 CREB regulated transcription coactivator 1
DGCR8 DGCR8 microprocessor complex subunit
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DPY19L1P1 DPY19L1 pseudogene 1
EMILIN2 elastin microfibril interfacer 2
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ESR1 estrogen receptor 1
EZR ezrin
FAM149B1 family with sequence similarity 149, member B1
FBXO21 F-box protein 21
FBXO22 F-box protein 22
FHL3 four and a half LIM domains 3
FLT1 fms-related tyrosine kinase 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GPER1 G protein-coupled estrogen receptor 1
GSK3A glycogen synthase kinase 3 alpha
GSTTP1 glutathione S-transferase theta pseudogene 1
GYPC glycophorin C (Gerbich blood group)
HEMK1 HemK methyltransferase family member 1
HIP1 huntingtin interacting protein 1
HNMT histamine N-methyltransferase
HPX hemopexin
HRK harakiri, BCL2 interacting protein
IL32 interleukin 32
ING2 inhibitor of growth family, member 2
JAK3 Janus kinase 3
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KDR kinase insert domain receptor
KLF12 Kruppel-like factor 12
KRAS Kirsten rat sarcoma viral oncogene homolog
LINC00216 long intergenic non-protein coding RNA 216
LOC390998 ribosomal protein L10 pseudogene
LTB4R leukotriene B4 receptor
LUZP4 leucine zipper protein 4
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MYRIP myosin VIIA and Rab interacting protein
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEUROD4 neuronal differentiation 4
NFX1 nuclear transcription factor, X-box binding 1
OLFM1 olfactomedin 1
OLFML2B olfactomedin-like 2B
PAWR PRKC, apoptosis, WT1, regulator
PCDHGA9 protocadherin gamma subfamily A, 9
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2R1 phospholipase A2 receptor 1, 180kDa
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POU2F3 POU class 2 homeobox 3
PTPRR protein tyrosine phosphatase, receptor type, R
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RANBP1 RAN binding protein 1
RAP1GAP RAP1 GTPase activating protein
RARA retinoic acid receptor, alpha
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RNF122 ring finger protein 122
RRH retinal pigment epithelium-derived rhodopsin homolog
SARM1 sterile alpha and TIR motif containing 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC25A30 solute carrier family 25, member 30
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMC1A structural maintenance of chromosomes 1A
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPPL2B signal peptide peptidase like 2B
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TBC1D30 TBC1 domain family, member 30
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TMEM206 transmembrane protein 206
TNPO2 transportin 2
TPSAB1 tryptase alpha/beta 1
TRO trophinin
TSC2 tuberous sclerosis 2
USP46 ubiquitin specific peptidase 46
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VPRBP Vpr (HIV-1) binding protein
ZBTB20 zinc finger and BTB domain containing 20
ZNF550 zinc finger protein 550
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACTC1 actin, alpha, cardiac muscle 1
AGMAT agmatine ureohydrolase (agmatinase)
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARSA arylsulfatase A
ATAT1 alpha tubulin acetyltransferase 1
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BEX1 brain expressed, X-linked 1
C11ORF68 chromosome 11 open reading frame 68
C17ORF80 chromosome 17 open reading frame 80
C5ORF45 chromosome 5 open reading frame 45
CA9 carbonic anhydrase IX
CCDC177 coiled-coil domain containing 177
CD101 CD101 molecule
CD53 CD53 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK3 cyclin-dependent kinase 3
CFAP45 cilia and flagella associated protein 45
CHRDL1 chordin-like 1
CNGB3 cyclic nucleotide gated channel beta 3
CNOT3 CCR4-NOT transcription complex, subunit 3
CORT cortistatin
CRMP1 collapsin response mediator protein 1
CRYBA2 crystallin, beta A2
CSF1R colony stimulating factor 1 receptor
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DOC2A double C2-like domains, alpha
DUSP8 dual specificity phosphatase 8
EPN1 epsin 1
EVPL envoplakin
FAM110B family with sequence similarity 110, member B
FKBP5 FK506 binding protein 5
FKBP8 FK506 binding protein 8, 38kDa
FLJ21369 uncharacterized protein FLJ21369
FLT4 fms-related tyrosine kinase 4
GMIP GEM interacting protein
GPR21 G protein-coupled receptor 21
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H2AJ histone cluster 1, H2aj
IL17RB interleukin 17 receptor B
IL2 interleukin 2
IL24 interleukin 24
IPO8 importin 8
KDM5C lysine (K)-specific demethylase 5C
KLHL36 kelch-like family member 36
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6G5C lymphocyte antigen 6 complex, locus G5C
LY86 lymphocyte antigen 86
LYRM9 LYR motif containing 9
MAPK3 mitogen-activated protein kinase 3
MCMBP minichromosome maintenance complex binding protein
MID1IP1 MID1 interacting protein 1
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MUC3B mucin 3B, cell surface associated
MYO1F myosin IF
MYOZ3 myozenin 3
NID2 nidogen 2 (osteonidogen)
NPFFR1 neuropeptide FF receptor 1
NTSR1 neurotensin receptor 1 (high affinity)
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
OCLN occludin
PARP3 poly (ADP-ribose) polymerase family, member 3
PAX9 paired box 9
PDE8B phosphodiesterase 8B
PICK1 protein interacting with PRKCA 1
PID1 phosphotyrosine interaction domain containing 1
PLA2G1B phospholipase A2, group IB (pancreas)
PLXNB3 plexin B3
POLL polymerase (DNA directed), lambda
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RNF126P1 ring finger protein 126 pseudogene 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S1PR1 sphingosine-1-phosphate receptor 1
SETD1A SET domain containing 1A
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLN sarcolipin
SMAD7 SMAD family member 7
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SYNGR3 synaptogyrin 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBX19 T-box 19
TLN1 talin 1
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAIP TRAF interacting protein
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TSC22D4 TSC22 domain family, member 4
TUBA4B tubulin, alpha 4b
ZDHHC14 zinc finger, DHHC-type containing 14
ZFHX3 zinc finger homeobox 3
ZNF222 zinc finger protein 222
ZNF711 zinc finger protein 711
ZNF749 zinc finger protein 749
ZYX zyxin