succinic semialdehyde dehydrogenase deficiency Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A gamma-amino butyric acid metabolism disorder that is characterized by a deficiency of succinic semialdehyde dehydrogenase resulting in elevated levels of gamma-hydroxybutyric acid. (Human Disease Ontology, DOID_0060175)
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Genes

52 genes co-occuring with the disease succinic semialdehyde dehydrogenase deficiency in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 4.32303
ABAT 4-aminobutyrate aminotransferase 2.57554
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 1.73186
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 1.37032
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 1.31144
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 1.03956
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.01554
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.968341
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.964148
D2HGDH D-2-hydroxyglutarate dehydrogenase 0.955361
CSAD cysteine sulfinic acid decarboxylase 0.941196
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.89623
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 0.842573
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.795821
PNPO pyridoxamine 5'-phosphate oxidase 0.754934
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.743954
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.73746
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.731381
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.701928
ADSL adenylosuccinate lyase 0.667947
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.664769
DCDC2 doublecortin domain containing 2 0.643797
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 0.629635
ANKK1 ankyrin repeat and kinase domain containing 1 0.626888
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 0.605762
KIAA0319 KIAA0319 0.597961
CRAT carnitine O-acetyltransferase 0.542379
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.523045
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.517265
MCPH1 microcephalin 1 0.504207
CHRM2 cholinergic receptor, muscarinic 2 0.482084
GCDH glutaryl-CoA dehydrogenase 0.436026
DTNBP1 dystrobrevin binding protein 1 0.429642
PHGDH phosphoglycerate dehydrogenase 0.388166
ASPA aspartoacylase 0.368888
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.336876
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.316092
TH tyrosine hydroxylase 0.305226
A1BG alpha-1-B glycoprotein 0.294053
LATS1 large tumor suppressor kinase 1 0.28616
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.278297
PC pyruvate carboxylase 0.272241
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.259124
ACO2 aconitase 2, mitochondrial 0.249257
SKP1 S-phase kinase-associated protein 1 0.246448
GPX5 glutathione peroxidase 5 0.237009
GPX4 glutathione peroxidase 4 0.234225
GPX1 glutathione peroxidase 1 0.220081
ELANE elastase, neutrophil expressed 0.171535
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.169091
CAT catalase 0.165874
SCN2A sodium channel, voltage gated, type II alpha subunit 0.158434