substance-related disorder Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. (Human Disease Ontology, DOID_303)
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Genes

164 genes associated with the disease substance-related disorder in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
RPL6 ribosomal protein L6 2.89288
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.874
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 2.40646
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.31206
TF transferrin 2.10453
HFE hemochromatosis 1.82071
IREB2 iron-responsive element binding protein 2 1.58223
CCDC63 coiled-coil domain containing 63 1.52269
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 1.52269
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 1.2894
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 1.2894
SRPRB signal recognition particle receptor, B subunit 1.22898
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 1.20117
HYKK hydroxylysine kinase 1.09588
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 1.09588
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.872896
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.790827
AHR aryl hydrocarbon receptor 0.790827
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.661797
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.65413
GOLGA2P1 golgin A2 pseudogene 1 0.63207
MORF4 mortality factor 4 (pseudogene) 0.63207
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.63207
PGM1 phosphoglucomutase 1 0.602429
NRCAM neuronal cell adhesion molecule 0.572184
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.552621
MREG melanoregulin 0.52461
PECR peroxisomal trans-2-enoyl-CoA reductase 0.52461
CDH13 cadherin 13 0.52461
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 0.52461
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.52461
EGLN2 egl-9 family hypoxia-inducible factor 2 0.52461
BDNF brain-derived neurotrophic factor 0.486425
SERINC2 serine incorporator 2 0.464771
RAB3B RAB3B, member RAS oncogene family 0.449873
PCNXL2 pecanex-like 2 (Drosophila) 0.449873
AUTS2 autism susceptibility candidate 2 0.449873
RASL11A RAS-like, family 11, member A 0.403461
TNN tenascin N 0.368757
RAB4B RAB4B, member RAS oncogene family 0.368757
BBX bobby sox homolog (Drosophila) 0.368757
C15ORF32 chromosome 15 open reading frame 32 0.345945
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.345945
C1ORF100 chromosome 1 open reading frame 100 0.345945
C7ORF66 chromosome 7 open reading frame 66 0.345945
NRD1 nardilysin (N-arginine dibasic convertase) 0.327313
SEC24C SEC24 family member C 0.327313
PTK2B protein tyrosine kinase 2 beta 0.311576
LINGO2 leucine rich repeat and Ig domain containing 2 0.311576
CPLX3 complexin 3 0.297866
C10ORF131 chromosome 10 open reading frame 131 0.297866
CC2D2B coiled-coil and C2 domain containing 2B 0.297866
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.297866
PPCDC phosphopantothenoylcysteine decarboxylase 0.297866
LMO1 LIM domain only 1 (rhombotin 1) 0.285417
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.274608
MBNL2 muscleblind-like splicing regulator 2 0.274608
NCALD neurocalcin delta 0.274608
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 0.274608
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.256228
PKNOX2 PBX/knotted 1 homeobox 2 0.256228
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.256228
RHCE Rh blood group, CcEe antigens 0.256228
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 0.256228
LOC646938 TBC1 domain family, member 2B pseudogene 0.256228
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.256228
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.197766
LINC00208 long intergenic non-protein coding RNA 208 0.197766
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.197766
AGBL3 ATP/GTP binding protein-like 3 0.197766
YY1 YY1 transcription factor 0.197766
ORC1 origin recognition complex, subunit 1 0.197766
TMEM108 transmembrane protein 108 0.197766
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.197766
ZNF608 zinc finger protein 608 0.197766
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.197766
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.15771
CAPN7 calpain 7 0.15771
CAB39 calcium binding protein 39 0.15771
SIX3 SIX homeobox 3 0.15771
MMP2 matrix metallopeptidase 2 0.15771
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.15771
C10ORF126 chromosome 10 open reading frame 126 0.15771
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.15771
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 0.126165
CLCN4 chloride channel, voltage-sensitive 4 0.126165
NXPH2 neurexophilin 2 0.126165
COL8A1 collagen, type VIII, alpha 1 0.126165
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 0.126165
AMPH amphiphysin 0.126165
ZNF124 zinc finger protein 124 0.126165
TMEM57 transmembrane protein 57 0.126165
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.126165
ARID5A AT rich interactive domain 5A (MRF1-like) 0.126165
NELL1 NEL-like 1 (chicken) 0.126165
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.126165
PLCL1 phospholipase C-like 1 0.126165
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 0.126165
FOXP4 forkhead box P4 0.126165
FANCL Fanconi anemia, complementation group L 0.126165
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.126165
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 0.126165
PCNX pecanex homolog (Drosophila) 0.126165
E2F7 E2F transcription factor 7 0.100789
SCARA3 scavenger receptor class A, member 3 0.100789
USP12 ubiquitin specific peptidase 12 0.100789
ZNF366 zinc finger protein 366 0.100789
ZCCHC11 zinc finger, CCHC domain containing 11 0.100789
MUC7 mucin 7, secreted 0.100789
CTTNBP2 cortactin binding protein 2 0.100789
PROX2 prospero homeobox 2 0.100789
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 0.100789
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.100789
GRM5 glutamate receptor, metabotropic 5 0.100789
ANKRD7 ankyrin repeat domain 7 0.100789
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.100789
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.080593
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.080593
FANCA Fanconi anemia, complementation group A 0.080593
CAAP1 caspase activity and apoptosis inhibitor 1 0.080593
GNAS GNAS complex locus 0.080593
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.080593
ARRDC3 arrestin domain containing 3 0.080593
GCLC glutamate-cysteine ligase, catalytic subunit 0.080593
FAM3C family with sequence similarity 3, member C 0.080593
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.080593
CABLES1 Cdk5 and Abl enzyme substrate 1 0.080593
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.080593
TRPC5 transient receptor potential cation channel, subfamily C, member 5 0.080593
PCDH15 protocadherin-related 15 0.080593
FAM179A family with sequence similarity 179, member A 0.080593
ZNF253 zinc finger protein 253 0.080593
GADD45G growth arrest and DNA-damage-inducible, gamma 0.080593
SYNJ2 synaptojanin 2 0.064973
PABPC1 poly(A) binding protein, cytoplasmic 1 0.064973
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.064973
ACTN1 actinin, alpha 1 0.064973
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha 0.064973
HIP1 huntingtin interacting protein 1 0.064973
MED12L mediator complex subunit 12-like 0.064973
ERAP1 endoplasmic reticulum aminopeptidase 1 0.064973
MAOA monoamine oxidase A 0.064973
C11ORF84 chromosome 11 open reading frame 84 0.064973
ZNF285 zinc finger protein 285 0.064973
ESRRG estrogen-related receptor gamma 0.064973
ESR1 estrogen receptor 1 0.052255
DCC DCC netrin 1 receptor 0.052255
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.052255
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.052255
SUCLG1 succinate-CoA ligase, alpha subunit 0.052255
SETD7 SET domain containing (lysine methyltransferase) 7 0.052255
FAM65B family with sequence similarity 65, member B 0.052255
KIAA0087 KIAA0087 0.052255
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 0.052255
FAT4 FAT atypical cadherin 4 0.043246
TRA2B transformer 2 beta homolog (Drosophila) 0.043246
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.043246
NGF nerve growth factor (beta polypeptide) 0.043246
EXOC5 exocyst complex component 5 0.043246
ANXA13 annexin A13 0.043246
TLR1 toll-like receptor 1 0.043246
SLC26A4 solute carrier family 26 (anion exchanger), member 4 0.043246
PLAU plasminogen activator, urokinase 0.035343
TPK1 thiamin pyrophosphokinase 1 0.035343