stratum corneum Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The horny outer layer of the epidermis, consisting mainly of dead or peeling cells. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000344)
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Genes

301 proteins co-occuring with the tissue stratum corneum in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
FLG filaggrin 3.41067
LOR loricrin 2.5786
IVL involucrin 2.54478
CDSN corneodesmosin 2.41764
KLK7 kallikrein-related peptidase 7 2.39037
KLK5 kallikrein-related peptidase 5 2.35753
SPINK5 serine peptidase inhibitor, Kazal type 5 2.28323
CASP14 caspase 14, apoptosis-related cysteine peptidase 2.15172
DSG1 desmoglein 1 2.12725
TGM1 transglutaminase 1 1.95093
GBA glucosidase, beta, acid 1.91278
KRT10 keratin 10, type I 1.84247
KLK6 kallikrein-related peptidase 6 1.82606
DSC1 desmocollin 1 1.76325
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 1.68204
SPINK6 serine peptidase inhibitor, Kazal type 6 1.67306
SPINK9 serine peptidase inhibitor, Kazal type 9 1.67106
CER1 cerberus 1, DAN family BMP antagonist 1.66807
TGM3 transglutaminase 3 1.64957
ILVBL ilvB (bacterial acetolactate synthase)-like 1.59671
KRT1 keratin 1, type II 1.57405
KLK14 kallikrein-related peptidase 14 1.54922
DNASE1L2 deoxyribonuclease I-like 2 1.42968
STS steroid sulfatase (microsomal), isozyme S 1.42876
RNASE7 ribonuclease, RNase A family, 7 1.42137
CTSV cathepsin V 1.40708
CTRL chymotrypsin-like 1.38413
LCE3B late cornified envelope 3B 1.37408
TMEM79 transmembrane protein 79 1.36906
ALOX12B arachidonate 12-lipoxygenase, 12R type 1.3604
CST6 cystatin E/M 1.35449
SCEL sciellin 1.34905
AQP3 aquaporin 3 (Gill blood group) 1.34542
LCE3C late cornified envelope 3C 1.34315
HAL histidine ammonia-lyase 1.33455
LCE1F late cornified envelope 1F 1.33139
IL1A interleukin 1, alpha 1.31739
ALOXE3 arachidonate lipoxygenase 3 1.30343
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 1.30253
KRT16 keratin 16, type I 1.29984
FLG2 filaggrin family member 2 1.27919
CALML5 calmodulin-like 5 1.25458
KRT9 keratin 9, type I 1.20689
KLK8 kallikrein-related peptidase 8 1.20245
KLK13 kallikrein-related peptidase 13 1.198
UGCG UDP-glucose ceramide glucosyltransferase 1.19267
HRNR hornerin 1.18645
LGMN legumain 1.17047
ST14 suppression of tumorigenicity 14 (colon carcinoma) 1.15939
ASPRV1 aspartic peptidase, retroviral-like 1 1.15894
DSG3 desmoglein 3 1.1111
CLDN1 claudin 1 1.11066
NIPAL4 NIPA-like domain containing 4 1.10225
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 1.10137
ZMYM2 zinc finger, MYM-type 2 1.10093
AATF apoptosis antagonizing transcription factor 1.07883
DEFB4A defensin, beta 4A 1.07529
KLK11 kallikrein-related peptidase 11 1.07441
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 1.06691
KLK1 kallikrein 1 1.05897
GJB4 gap junction protein, beta 4, 30.3kDa 1.04664
TCHH trichohyalin 1.04445
LCE3D late cornified envelope 3D 1.019
SKIDA1 SKI/DACH domain containing 1 1.01243
TSLP thymic stromal lymphopoietin 1.00719
TGM5 transglutaminase 5 0.996295
LCE3A late cornified envelope 3A 0.992379
CERS1 ceramide synthase 1 0.981518
KRT14 keratin 14, type I 0.977616
CLDN7 claudin 7 0.977182
SPRR4 small proline-rich protein 4 0.971552
KRTDAP keratinocyte differentiation-associated protein 0.960744
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.953409
CLDN4 claudin 4 0.927192
PRSS8 protease, serine, 8 0.924623
KLK12 kallikrein-related peptidase 12 0.922055
LYPD2 LY6/PLAUR domain containing 2 0.919061
S100A7 S100 calcium binding protein A7 0.912653
CTSL cathepsin L 0.90285
TSPO translocator protein (18kDa) 0.900296
CSTA cystatin A (stefin A) 0.893921
BLMH bleomycin hydrolase 0.888405
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.887981
CAMP cathelicidin antimicrobial peptide 0.874862
DEFB127 defensin, beta 127 0.850845
IGF2-AS IGF2 antisense RNA 0.840349
PAPL iron/zinc purple acid phosphatase-like protein 0.836156
CTSD cathepsin D 0.814397
PSAP prosaposin 0.808134
CERS3 ceramide synthase 3 0.801459
KRT5 keratin 5, type II 0.798125
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.790212
ELOVL4 ELOVL fatty acid elongase 4 0.789796
LAP3 leucine aminopeptidase 3 0.788964
JUP junction plakoglobin 0.786052
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 0.771514
EMP3 epithelial membrane protein 3 0.766539
C21ORF91 chromosome 21 open reading frame 91 0.752884
CCL27 chemokine (C-C motif) ligand 27 0.751645
SH3GLB2 SH3-domain GRB2-like endophilin B2 0.722398
ANKK1 ankyrin repeat and kinase domain containing 1 0.717882
IL1RL2 interleukin 1 receptor-like 2 0.71501
KRTAP11-1 keratin associated protein 11-1 0.712959
OCLN occludin 0.71009
GRHL3 grainyhead-like 3 (Drosophila) 0.706402
KRT7 keratin 7, type II 0.688409
SPRR3 small proline-rich protein 3 0.677803
PPARD peroxisome proliferator-activated receptor delta 0.676987
IL31 interleukin 31 0.674135
LYZ lysozyme 0.670878
C5AR1 complement component 5a receptor 1 0.666809
AQP10 aquaporin 10 0.665995
KRT2 keratin 2, type II 0.663555
CCL17 chemokine (C-C motif) ligand 17 0.659897
MED6 mediator complex subunit 6 0.659897
PPARA peroxisome proliferator-activated receptor alpha 0.659085
SCAND2P SCAN domain containing 2 pseudogene 0.650154
DAND5 DAN domain family member 5, BMP antagonist 0.637999
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.637594
INS insulin 0.636785
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 0.619007
C12ORF10 chromosome 12 open reading frame 10 0.607319
MAMDC4 MAM domain containing 4 0.605709
ALB albumin 0.59405
CES1P1 carboxylesterase 1 pseudogene 1 0.584422
SMNDC1 survival motor neuron domain containing 1 0.577615
ABHD14A abhydrolase domain containing 14A 0.577615
SPRR1B small proline-rich protein 1B 0.576816
FA2H fatty acid 2-hydroxylase 0.56603
DSP desmoplakin 0.559652
UBIAD1 UbiA prenyltransferase domain containing 1 0.559254
SBK1 SH3 domain binding kinase 1 0.558856
ACPP acid phosphatase, prostate 0.55607
CLEC6A C-type lectin domain family 6, member A 0.554876
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase 0.548517
CES1 carboxylesterase 1 0.545342
RPTN repetin 0.541377
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 0.537021
TECR trans-2,3-enoyl-CoA reductase 0.53346
DKKL1 dickkopf-like 1 0.53346
DEFB103A defensin, beta 103A 0.530693
IL1B interleukin 1, beta 0.529113
ARSH arylsulfatase family, member H 0.527534
TRIM37 tripartite motif containing 37 0.519647
SSR1 signal sequence receptor, alpha 0.517678
PADI2 peptidyl arginine deiminase, type II 0.51571
TNF tumor necrosis factor 0.513743
TMC8 transmembrane channel-like 8 0.50942
PCNA proliferating cell nuclear antigen 0.507064
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 0.503141
BTG3 BTG family, member 3 0.501182
DMKN dermokine 0.500007
GJB3 gap junction protein, beta 3, 31kDa 0.498048
EPN1 epsin 1 0.493745
LPP LIM domain containing preferred translocation partner in lipoma 0.491791
PADI3 peptidyl arginine deiminase, type III 0.487106
DEFB1 defensin, beta 1 0.484376
AK2 adenylate kinase 2 0.483986
ELANE elastase, neutrophil expressed 0.482038
ELOVL1 ELOVL fatty acid elongase 1 0.478534
DNASE1 deoxyribonuclease I 0.477756
DEFB103B defensin, beta 103B 0.475812
ADSL adenylosuccinate lyase 0.475812
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.47348
KLK15 kallikrein-related peptidase 15 0.471927
SLPI secretory leukocyte peptidase inhibitor 0.471151
ELOVL3 ELOVL fatty acid elongase 3 0.468048
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.46766
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.461078
KLK10 kallikrein-related peptidase 10 0.460692
FGD1 FYVE, RhoGEF and PH domain containing 1 0.45374
KRT81 keratin 81, type II 0.450657
CD79A CD79a molecule, immunoglobulin-associated alpha 0.450657
EMILIN2 elastin microfibril interfacer 2 0.450271
ICAM1 intercellular adhesion molecule 1 0.450271
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.447192
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 0.444115
KITLG KIT ligand 0.442962
MMP1 matrix metallopeptidase 1 0.442578
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.435672
CD44 CD44 molecule (Indian blood group) 0.435289
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.434906
TYR tyrosinase 0.433374
PLA2G10 phospholipase A2, group X 0.420766
IPP intracisternal A particle-promoted polypeptide 0.416576
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.407453
TP63 tumor protein p63 0.401386
ABHD5 abhydrolase domain containing 5 0.399871
COASY CoA synthase 0.395331
MYOM1 myomesin 1 0.395331
SLURP1 secreted LY6/PLAUR domain containing 1 0.393819
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.389289
SUN1 Sad1 and UNC84 domain containing 1 0.38552
TJP1 tight junction protein 1 0.382508
COL1A2 collagen, type I, alpha 2 0.379875
PLA2G15 phospholipase A2, group XV 0.378748
DUSP16 dual specificity phosphatase 16 0.378748
GJA1 gap junction protein, alpha 1, 43kDa 0.377996
CERS6 ceramide synthase 6 0.375368
CSN1S1 casein alpha s1 0.368998
LYNX1 Ly6/neurotoxin 1 0.363766
GRIK4 glutamate receptor, ionotropic, kainate 4 0.363766
KRT86 keratin 86, type II 0.352227
TMPRSS13 transmembrane protease, serine 13 0.348519
CHURC1 churchill domain containing 1 0.348519
IL1RN interleukin 1 receptor antagonist 0.347408
DSG4 desmoglein 4 0.345928
FGF7 fibroblast growth factor 7 0.340757
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.338914
CCL14 chemokine (C-C motif) ligand 14 0.338914
HRAS Harvey rat sarcoma viral oncogene homolog 0.334498
LOX lysyl oxidase 0.324605
MLX MLX, MAX dimerization protein 0.323144
AMICA1 adhesion molecule, interacts with CXADR antigen 1 0.322779
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 0.32132
CLK1 CDC-like kinase 1 0.320227
CTSE cathepsin E 0.31877
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.314772
RBM4 RNA binding motif protein 4 0.312957
IL19 interleukin 19 0.312232
HBD hemoglobin, delta 0.306805
CTSG cathepsin G 0.306444
DSC3 desmocollin 3 0.303559
NOTCH1 notch 1 0.302478
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.301758
RBMS1 RNA binding motif, single stranded interacting protein 1 0.30032
LPIN2 lipin 2 0.29996
THUMPD1 THUMP domain containing 1 0.299601
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.297806
FURIN furin (paired basic amino acid cleaving enzyme) 0.297806
TP53 tumor protein p53 0.293866
TERT telomerase reverse transcriptase 0.291365
GLB1 galactosidase, beta 1 0.288514
CRABP2 cellular retinoic acid binding protein 2 0.282483
MTUS1 microtubule associated tumor suppressor 1 0.279659
CAT catalase 0.278955
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.2779
CARD17 caspase recruitment domain family, member 17 0.274394
HGFAC HGF activator 0.274045
CABIN1 calcineurin binding protein 1 0.270561
PI3 peptidase inhibitor 3, skin-derived 0.266757
MMP9 matrix metallopeptidase 9 0.265725
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.264353
PRODH proline dehydrogenase (oxidase) 1 0.254902
PPARG peroxisome proliferator-activated receptor gamma 0.254239
CCL22 chemokine (C-C motif) ligand 22 0.252919
MEP1B meprin A, beta 0.25259
MEP1A meprin A, alpha (PABA peptide hydrolase) 0.250301
GGCT gamma-glutamylcyclotransferase 0.248683
FN1 fibronectin 1 0.246124
DNAH8 dynein, axonemal, heavy chain 8 0.245807
KLK4 kallikrein-related peptidase 4 0.245491
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 0.241746
DBP D site of albumin promoter (albumin D-box) binding protein 0.241438
KRT15 keratin 15, type I 0.240216
CFB complement factor B 0.237216
XPC xeroderma pigmentosum, complementation group C 0.236332
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.23604
DNTT DNA nucleotidylexotransferase 0.235167
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.23459
EPHB6 EPH receptor B6 0.233162
EVPL envoplakin 0.232599
SUB1 SUB1 homolog (S. cerevisiae) 0.230931
ALOX15B arachidonate 15-lipoxygenase, type B 0.230656
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.228234
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 0.22797
COLEC12 collectin sub-family member 12 0.226155
PLA2G1B phospholipase A2, group IB (pancreas) 0.22415
TMC6 transmembrane channel-like 6 0.223419
ALPPL2 alkaline phosphatase, placental-like 2 0.223177
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.223177
ALPL alkaline phosphatase, liver/bone/kidney 0.222699
ALPP alkaline phosphatase, placental 0.222224
CST4 cystatin S 0.219264
FAM155B family with sequence similarity 155, member B 0.217554
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.217346
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.217346
WHSC1 Wolf-Hirschhorn syndrome candidate 1 0.217346
SLC7A4 solute carrier family 7, member 4 0.215341
HBB hemoglobin, beta 0.214388
OGFR opioid growth factor receptor 0.214202
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.213833
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.213471
KRT75 keratin 75, type II 0.199283
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.199283
ATG12 autophagy related 12 0.198684
TUBD1 tubulin, delta 1 0.198478
OCM2 oncomodulin 2 0.198386
DGAT2 diacylglycerol O-acyltransferase 2 0.198373
OCM oncomodulin 0.19826
HRG histidine-rich glycoprotein 0.19714
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.196904
PRDM1 PR domain containing 1, with ZNF domain 0.19647
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.195407
CAPNS1 calpain, small subunit 1 0.19474
CHL1 cell adhesion molecule L1-like 0.193917
PRSS3 protease, serine, 3 0.192207
CARS cysteinyl-tRNA synthetase 0.192092
HLA-C major histocompatibility complex, class I, C 0.191497
ATG7 autophagy related 7 0.190562
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.190012