spotted fever Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that results_in infection, located_in endothelial cell of artery or located_in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted_by ticks and mites. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom muscle aches, and has_symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite. (Human Disease Ontology, DOID_11104)
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Genes

116 genes co-occuring with the disease spotted fever in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
AFF2 AF4/FMR2 family, member 2 1.86461
CS citrate synthase 1.70633
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 1.46759
SOCS1 suppressor of cytokine signaling 1 1.35115
IRS4 insulin receptor substrate 4 1.09713
USP18 ubiquitin specific peptidase 18 0.966663
MTCP1 mature T-cell proliferation 1 0.943274
IRF9 interferon regulatory factor 9 0.933727
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.863046
ISG15 ISG15 ubiquitin-like modifier 0.718039
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.689492
THADA thyroid adenoma associated 0.621792
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 0.616312
CCL2 chemokine (C-C motif) ligand 2 0.593674
GBP1 guanylate binding protein 1, interferon-inducible 0.581606
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.560616
USP9X ubiquitin specific peptidase 9, X-linked 0.551298
THBD thrombomodulin 0.541217
F3 coagulation factor III (thromboplastin, tissue factor) 0.537731
G6PD glucose-6-phosphate dehydrogenase 0.531154
SPTBN2 spectrin, beta, non-erythrocytic 2 0.514571
CRP C-reactive protein, pentraxin-related 0.504973
TNF tumor necrosis factor 0.487027
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.487027
VWF von Willebrand factor 0.460506
IL2RA interleukin 2 receptor, alpha 0.453716
AVP arginine vasopressin 0.450701
SELE selectin E 0.448064
ADRA2A adrenoceptor alpha 2A 0.437154
IL1A interleukin 1, alpha 0.436778
C5ORF38 chromosome 5 open reading frame 38 0.435651
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.42814
SCAI suppressor of cancer cell invasion 0.416147
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.403811
CLDN11 claudin 11 0.393746
ISG20 interferon stimulated exonuclease gene 20kDa 0.391513
YAP1 Yes-associated protein 1 0.390769
ALPPL2 alkaline phosphatase, placental-like 2 0.388538
ALPP alkaline phosphatase, placental 0.388166
ALPL alkaline phosphatase, liver/bone/kidney 0.387423
F12 coagulation factor XII (Hageman factor) 0.382223
IL10 interleukin 10 0.374438
STAB2 stabilin 2 0.363347
CXCL10 chemokine (C-X-C motif) ligand 10 0.340906
IFNG interferon, gamma 0.338341
CAV2 caveolin 2 0.331025
HMOX1 heme oxygenase 1 0.329565
ICAM1 intercellular adhesion molecule 1 0.321181
CXCL9 chemokine (C-X-C motif) ligand 9 0.305587
IFT122 intraflagellar transport 122 0.301615
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.299092
CD4 CD4 molecule 0.297291
BRD1 bromodomain containing 1 0.29118
PLG plasminogen 0.289744
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.281868
CXCR3 chemokine (C-X-C motif) receptor 3 0.278297
CTTN cortactin 0.269398
CARS cysteinyl-tRNA synthetase 0.269043
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.249608
IRF7 interferon regulatory factor 7 0.244696
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.244345
PFN4 profilin family, member 4 0.240847
TLR4 toll-like receptor 4 0.233183
LPO lactoperoxidase 0.230063
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.227642
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.225229
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.225229
VCAM1 vascular cell adhesion molecule 1 0.220766
VASP vasodilator-stimulated phosphoprotein 0.21974
FH fumarate hydratase 0.213621
CXCL2 chemokine (C-X-C motif) ligand 2 0.210589
IVD isovaleryl-CoA dehydrogenase 0.206248
PLAT plasminogen activator, tissue 0.204923
CCNE1 cyclin E1 0.201635
STAT1 signal transducer and activator of transcription 1, 91kDa 0.19582
ATR ATR serine/threonine kinase 0.193915
PFN1 profilin 1 0.189244
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.183835
PFN2 profilin 2 0.182666
TES testin LIM domain protein 0.18151
F2 coagulation factor II (thrombin) 0.17896
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.172544
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.170544
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.167452
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.159124
CCL13 chemokine (C-C motif) ligand 13 0.137568
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.127052
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.124697
CCL3 chemokine (C-C motif) ligand 3 0.118051
TLR2 toll-like receptor 2 0.110263
PXN paxillin 0.109662
CD40LG CD40 ligand 0.109502
VCL vinculin 0.108497
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.107666
TSPO translocator protein (18kDa) 0.107633
GGT1 gamma-glutamyltransferase 1 0.106784
MMP12 matrix metallopeptidase 12 0.106472
DIABLO diablo, IAP-binding mitochondrial protein 0.10567
IRF1 interferon regulatory factor 1 0.104124
PAH phenylalanine hydroxylase 0.103832
EZR ezrin 0.103723
IDO1 indoleamine 2,3-dioxygenase 1 0.10142
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.100796
KNG1 kininogen 1 0.100521
MX1 MX dynamin-like GTPase 1 0.09961
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.099249
LYZ lysozyme 0.098889
CXCL8 chemokine (C-X-C motif) ligand 8 0.09844
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.096911
CD68 CD68 molecule 0.096786
TPM1 tropomyosin 1 (alpha) 0.095858
CDC42 cell division cycle 42 0.095816
SELL selectin L 0.092773
DNAH8 dynein, axonemal, heavy chain 8 0.09143
RARA retinoic acid receptor, alpha 0.09134
F8 coagulation factor VIII, procoagulant component 0.090708