splitomicin-661 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the splitomicin-661 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ACOT9 acyl-CoA thioesterase 9
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
AKAP13 A kinase (PRKA) anchor protein 13
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARNT aryl hydrocarbon receptor nuclear translocator
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATG13 autophagy related 13
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
BICD1 bicaudal D homolog 1 (Drosophila)
BICD2 bicaudal D homolog 2 (Drosophila)
C10ORF76 chromosome 10 open reading frame 76
C19ORF66 chromosome 19 open reading frame 66
CASKIN2 CASK interacting protein 2
CCHCR1 coiled-coil alpha-helical rod protein 1
CCNG2 cyclin G2
CD8A CD8a molecule
CDC6 cell division cycle 6
CHMP6 charged multivesicular body protein 6
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COMMD8 COMM domain containing 8
CPOX coproporphyrinogen oxidase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DPP4 dipeptidyl-peptidase 4
DUS2 dihydrouridine synthase 2
E2F3 E2F transcription factor 3
EFNB3 ephrin-B3
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ELF4 E74-like factor 4 (ets domain transcription factor)
ELMO2 engulfment and cell motility 2
EPOR erythropoietin receptor
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOSC9 exosome component 9
FAF2 Fas associated factor family member 2
FBXW4 F-box and WD repeat domain containing 4
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GNA12 guanine nucleotide binding protein (G protein) alpha 12
HFE hemochromatosis
HIST1H1T histone cluster 1, H1t
HIST1H3G histone cluster 1, H3g
HPSE heparanase
KANK1 KN motif and ankyrin repeat domains 1
KLHL9 kelch-like family member 9
LUZP1 leucine zipper protein 1
MED18 mediator complex subunit 18
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP1 NEDD4 binding protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NPAT nuclear protein, ataxia-telangiectasia locus
NRP1 neuropilin 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHC1 polyhomeotic homolog 1 (Drosophila)
PHKB phosphorylase kinase, beta
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLCL2 phospholipase C-like 2
PNPLA4 patatin-like phospholipase domain containing 4
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PSG6 pregnancy specific beta-1-glycoprotein 6
PSMC3IP PSMC3 interacting protein
RAB1B RAB1B, member RAS oncogene family
RAB27A RAB27A, member RAS oncogene family
RARG retinoic acid receptor, gamma
RNF141 ring finger protein 141
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RUFY3 RUN and FYVE domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIAH1 siah E3 ubiquitin protein ligase 1
SIM2 single-minded family bHLH transcription factor 2
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMO smoothened, frizzled class receptor
SMYD5 SMYD family member 5
SORBS3 sorbin and SH3 domain containing 3
SPEG SPEG complex locus
SPN sialophorin
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYT2 synaptotagmin II
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TK2 thymidine kinase 2, mitochondrial
TLN1 talin 1
TMC6 transmembrane channel-like 6
TPST2 tyrosylprotein sulfotransferase 2
TRAC T cell receptor alpha constant
TRIM8 tripartite motif containing 8
UBE2O ubiquitin-conjugating enzyme E2O
USF2 upstream transcription factor 2, c-fos interacting
VAV2 vav 2 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
ZNF335 zinc finger protein 335
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA2P1 annexin A2 pseudogene 1
APOB apolipoprotein B
AQP2 aquaporin 2 (collecting duct)
AQP8 aquaporin 8
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AVPR1B arginine vasopressin receptor 1B
AXIN1 axin 1
BPIFA1 BPI fold containing family A, member 1
C14ORF79 chromosome 14 open reading frame 79
C9ORF91 chromosome 9 open reading frame 91
CADPS2 Ca++-dependent secretion activator 2
CAV3 caveolin 3
CCDC71 coiled-coil domain containing 71
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD79A CD79a molecule, immunoglobulin-associated alpha
CFAP70 cilia and flagella associated protein 70
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CPA4 carboxypeptidase A4
CTRB2 chymotrypsinogen B2
CTRC chymotrypsin C (caldecrin)
CTRL chymotrypsin-like
CXCL9 chemokine (C-X-C motif) ligand 9
DCLRE1A DNA cross-link repair 1A
DHRS11 dehydrogenase/reductase (SDR family) member 11
DOCK1 dedicator of cytokinesis 1
DRD5 dopamine receptor D5
F2R coagulation factor II (thrombin) receptor
FAM189A2 family with sequence similarity 189, member A2
FOXC1 forkhead box C1
GAS8-AS1 GAS8 antisense RNA 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GML glycosylphosphatidylinositol anchored molecule like
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GP6 glycoprotein VI (platelet)
GPR3 G protein-coupled receptor 3
GPX2 glutathione peroxidase 2
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFNA17 interferon, alpha 17
INE1 inactivation escape 1 (non-protein coding)
IVL involucrin
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLF11 Kruppel-like factor 11
KLF15 Kruppel-like factor 15
KRT1 keratin 1, type II
LINC01558 long intergenic non-protein coding RNA 1558
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LY6G6C lymphocyte antigen 6 complex, locus G6C
LY6G6D lymphocyte antigen 6 complex, locus G6D
MED22 mediator complex subunit 22
MEFV Mediterranean fever
MLXIPL MLX interacting protein-like
MT4 metallothionein 4
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCS1 neuronal calcium sensor 1
NOL6 nucleolar protein 6 (RNA-associated)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NXPH4 neurexophilin 4
OLFML2A olfactomedin-like 2A
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PARG poly (ADP-ribose) glycohydrolase
PC pyruvate carboxylase
PKD2L1 polycystic kidney disease 2-like 1
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PON3 paraoxonase 3
PRODH2 proline dehydrogenase (oxidase) 2
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RCVRN recoverin
RNF39 ring finger protein 39
S100A12 S100 calcium binding protein A12
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SSTR4 somatostatin receptor 4
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TIAM2 T-cell lymphoma invasion and metastasis 2
TMEM204 transmembrane protein 204
TMEM74B transmembrane protein 74B
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TTR transthyretin
USP6 ubiquitin specific peptidase 6
VPREB3 pre-B lymphocyte 3
VSIG10 V-set and immunoglobulin domain containing 10
ZBTB48 zinc finger and BTB domain containing 48
ZFP30 ZFP30 zinc finger protein
ZNF197 zinc finger protein 197
ZNF253 zinc finger protein 253
ZNF816 zinc finger protein 816
ZNRD1-AS1 ZNRD1 antisense RNA 1