spleen hyperplasia Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description overdevelopment or increased size, usually due to increased cell number, in the spleen (Mammalian Phenotype Ontology, MP_0000693)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000693
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Genes

75 gene mutations causing the spleen hyperplasia phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACKR4 atypical chemokine receptor 4
ASXL1 additional sex combs like transcriptional regulator 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BMF Bcl2 modifying factor
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CARD11 caspase recruitment domain family, member 11
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNE1 cyclin E1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CISH cytokine inducible SH2-containing protein
CYCS cytochrome c, somatic
DIDO1 death inducer-obliterator 1
DTX1 deltex 1, E3 ubiquitin ligase
ESR2 estrogen receptor 2 (ER beta)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GPR83 G protein-coupled receptor 83
HMOX1 heme oxygenase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL10RB interleukin 10 receptor, beta
IL2 interleukin 2
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
ING2 inhibitor of growth family, member 2
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF8 interferon regulatory factor 8
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF13 Kruppel-like factor 13
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCN2 lipocalin 2
LDHA lactate dehydrogenase A
LTB lymphotoxin beta (TNF superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MARK2 MAP/microtubule affinity-regulating kinase 2
MFGE8 milk fat globule-EGF factor 8 protein
MIR144 microRNA 144
MIR451A microRNA 451a
NCKAP1L NCK-associated protein 1-like
NEU1 sialidase 1 (lysosomal sialidase)
PAWR PRKC, apoptosis, WT1, regulator
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAD50 RAD50 homolog (S. cerevisiae)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SAC3D1 SAC3 domain containing 1
SELL selectin L
SH2B3 SH2B adaptor protein 3
SIPA1 signal-induced proliferation-associated 1
SPI1 Spi-1 proto-oncogene
TANK TRAF family member-associated NFKB activator
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TRAF3IP2 TRAF3 interacting protein 2
UNG uracil-DNA glycosylase
WAS Wiskott-Aldrich syndrome
ZFP36 ZFP36 ring finger protein