spironolactone-2226 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the spironolactone-2226 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ACRV1 acrosomal vesicle protein 1
AIRE autoimmune regulator
AK1 adenylate kinase 1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCL2 B-cell CLL/lymphoma 2
C17ORF59 chromosome 17 open reading frame 59
C22ORF46 chromosome 22 open reading frame 46
CD248 CD248 molecule, endosialin
CD48 CD48 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CNTN1 contactin 1
COL1A1 collagen, type I, alpha 1
CPED1 cadherin-like and PC-esterase domain containing 1
CSNK1G1 casein kinase 1, gamma 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DEFA5 defensin, alpha 5, Paneth cell-specific
DGAT1 diacylglycerol O-acyltransferase 1
DGCR2 DiGeorge syndrome critical region gene 2
DGCR8 DGCR8 microprocessor complex subunit
DRD2 dopamine receptor D2
EDNRA endothelin receptor type A
EFNB3 ephrin-B3
EMC1 ER membrane protein complex subunit 1
FBXO4 F-box protein 4
FGF12 fibroblast growth factor 12
FRMD1 FERM domain containing 1
FXYD2 FXYD domain containing ion transport regulator 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GLRX glutaredoxin (thioltransferase)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GOLGA8A golgin A8 family, member A
HBEGF heparin-binding EGF-like growth factor
HFE hemochromatosis
HHLA1 HERV-H LTR-associating 1
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXA10 homeobox A10
HOXC5 homeobox C5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL2RB interleukin 2 receptor, beta
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITGB4 integrin, beta 4
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KEL Kell blood group, metallo-endopeptidase
LAMP1 lysosomal-associated membrane protein 1
LTBP4 latent transforming growth factor beta binding protein 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAN1A2 mannosidase, alpha, class 1A, member 2
METTL7A methyltransferase like 7A
MKL1 megakaryoblastic leukemia (translocation) 1
MTCP1 mature T-cell proliferation 1
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYL10 myosin, light chain 10, regulatory
NAT6 N-acetyltransferase 6 (GCN5-related)
NCALD neurocalcin delta
NF2 neurofibromin 2 (merlin)
NPY2R neuropeptide Y receptor Y2
NXF2 nuclear RNA export factor 2
OAZ3 ornithine decarboxylase antizyme 3
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PARD6B par-6 family cell polarity regulator beta
PGR progesterone receptor
PHF8 PHD finger protein 8
PLCD1 phospholipase C, delta 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PSG4 pregnancy specific beta-1-glycoprotein 4
PVR poliovirus receptor
RAB40AL RAB40A, member RAS oncogene family-like
RAB6B RAB6B, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM5 RNA binding motif protein 5
REEP2 receptor accessory protein 2
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF122 ring finger protein 122
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SH3BP2 SH3-domain binding protein 2
SIRT5 sirtuin 5
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SMAD1 SMAD family member 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SUGP1 SURP and G patch domain containing 1
SULT4A1 sulfotransferase family 4A, member 1
TEX14 testis expressed 14
TGFA transforming growth factor, alpha
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNS1 tensin 1
TPK1 thiamin pyrophosphokinase 1
TRIM29 tripartite motif containing 29
VEZT vezatin, adherens junctions transmembrane protein
ZFHX2 zinc finger homeobox 2

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAP2 ArfGAP with dual PH domains 2
ARC activity-regulated cytoskeleton-associated protein
ARHGAP4 Rho GTPase activating protein 4
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
AXIN1 axin 1
C14ORF93 chromosome 14 open reading frame 93
C1ORF105 chromosome 1 open reading frame 105
C1QTNF3 C1q and tumor necrosis factor related protein 3
C9ORF9 chromosome 9 open reading frame 9
CCDC134 coiled-coil domain containing 134
CD79B CD79b molecule, immunoglobulin-associated beta
CD82 CD82 molecule
CDON cell adhesion associated, oncogene regulated
CEL carboxyl ester lipase
CLCF1 cardiotrophin-like cytokine factor 1
CLCN6 chloride channel, voltage-sensitive 6
CLDN1 claudin 1
CSF1R colony stimulating factor 1 receptor
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK5 docking protein 5
DTX2 deltex 2, E3 ubiquitin ligase
EGFL7 EGF-like-domain, multiple 7
F2R coagulation factor II (thrombin) receptor
FAM110B family with sequence similarity 110, member B
FAM155A family with sequence similarity 155, member A
FAM160B2 family with sequence similarity 160, member B2
FBRS fibrosin
FLT4 fms-related tyrosine kinase 4
FURIN furin (paired basic amino acid cleaving enzyme)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRPR gastrin-releasing peptide receptor
HIST1H2AK histone cluster 1, H2ak
HIST1H3E histone cluster 1, H3e
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA0125 KIAA0125
KRT15 keratin 15, type I
LAMP3 lysosomal-associated membrane protein 3
LOC390998 ribosomal protein L10 pseudogene
LRRC49 leucine rich repeat containing 49
LRRC61 leucine rich repeat containing 61
LRRC8E leucine rich repeat containing 8 family, member E
MATK megakaryocyte-associated tyrosine kinase
MCOLN1 mucolipin 1
MEIS2 Meis homeobox 2
MFSD11 major facilitator superfamily domain containing 11
MTCL1 microtubule crosslinking factor 1
MYOZ1 myozenin 1
NIPAL2 NIPA-like domain containing 2
NKX3-2 NK3 homeobox 2
NLRX1 NLR family member X1
NRGN neurogranin (protein kinase C substrate, RC3)
NXPH4 neurexophilin 4
OLFML2A olfactomedin-like 2A
OVOL1 ovo-like zinc finger 1
PADI1 peptidyl arginine deiminase, type I
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PICK1 protein interacting with PRKCA 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLAC1 placenta-specific 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PODXL2 podocalyxin-like 2
POM121 POM121 transmembrane nucleoporin
POMT2 protein-O-mannosyltransferase 2
PQLC2 PQ loop repeat containing 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PROS1 protein S (alpha)
PRSS22 protease, serine, 22
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS20 regulator of G-protein signaling 20
SEC14L5 SEC14-like 5 (S. cerevisiae)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLIT2 slit homolog 2 (Drosophila)
SPRYD7 SPRY domain containing 7
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBC1D17 TBC1 domain family, member 17
TBC1D19 TBC1 domain family, member 19
TDRD1 tudor domain containing 1
TICAM1 toll-like receptor adaptor molecule 1
TMCC2 transmembrane and coiled-coil domain family 2
TMPRSS4 transmembrane protease, serine 4
TRAIP TRAF interacting protein
TUBA3C tubulin, alpha 3c
TYRP1 tyrosinase-related protein 1
WNT10B wingless-type MMTV integration site family, member 10B
XDH xanthine dehydrogenase
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF506 zinc finger protein 506
ZNF516 zinc finger protein 516
ZNF770 zinc finger protein 770
ZSCAN31 zinc finger and SCAN domain containing 31