spiramycin-4319 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the spiramycin-4319 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADAM15 ADAM metallopeptidase domain 15
ARTN artemin
ATP11A ATPase, class VI, type 11A
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B9D1 B9 protein domain 1
B9D2 B9 protein domain 2
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BTD biotinidase
CALU calumenin
CAMK4 calcium/calmodulin-dependent protein kinase IV
CDK10 cyclin-dependent kinase 10
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLTCL1 clathrin, heavy chain-like 1
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
CRTC1 CREB regulated transcription coactivator 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DGKA diacylglycerol kinase, alpha 80kDa
DMBT1 deleted in malignant brain tumors 1
DOK4 docking protein 4
DPYSL4 dihydropyrimidinase-like 4
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
EDN1 endothelin 1
ELMO2 engulfment and cell motility 2
FHL1 four and a half LIM domains 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUBP1 far upstream element (FUSE) binding protein 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GPER1 G protein-coupled estrogen receptor 1
GPR137 G protein-coupled receptor 137
GPR19 G protein-coupled receptor 19
GRK4 G protein-coupled receptor kinase 4
GRM7 glutamate receptor, metabotropic 7
HAP1 huntingtin-associated protein 1
HDAC11 histone deacetylase 11
IL11 interleukin 11
IQSEC2 IQ motif and Sec7 domain 2
KIAA1644 KIAA1644
KITLG KIT ligand
KLHL22 kelch-like family member 22
KMT2A lysine (K)-specific methyltransferase 2A
LPCAT3 lysophosphatidylcholine acyltransferase 3
LPIN1 lipin 1
MAPK14 mitogen-activated protein kinase 14
MEF2D myocyte enhancer factor 2D
MFAP3 microfibrillar-associated protein 3
MLXIP MLX interacting protein
MTMR1 myotubularin related protein 1
MUC7 mucin 7, secreted
NBEAL2 neurobeachin-like 2
NCOA3 nuclear receptor coactivator 3
NEK9 NIMA-related kinase 9
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR2F6 nuclear receptor subfamily 2, group F, member 6
OLFML2B olfactomedin-like 2B
OPRL1 opiate receptor-like 1
PAWR PRKC, apoptosis, WT1, regulator
PAX9 paired box 9
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PICALM phosphatidylinositol binding clathrin assembly protein
PLA1A phospholipase A1 member A
PLD1 phospholipase D1, phosphatidylcholine-specific
PLK4 polo-like kinase 4
POLM polymerase (DNA directed), mu
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB2A RAB2A, member RAS oncogene family
RBMS2 RNA binding motif, single stranded interacting protein 2
RGS14 regulator of G-protein signaling 14
RGS5 regulator of G-protein signaling 5
RPL23 ribosomal protein L23
RXRB retinoid X receptor, beta
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIRPA signal-regulatory protein alpha
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SORT1 sortilin 1
SP1 Sp1 transcription factor
SPRED2 sprouty-related, EVH1 domain containing 2
STC1 stanniocalcin 1
TBC1D2 TBC1 domain family, member 2
TBC1D30 TBC1 domain family, member 30
TBC1D5 TBC1 domain family, member 5
TLE4 transducin-like enhancer of split 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNPO2 transportin 2
TNXB tenascin XB
VPRBP Vpr (HIV-1) binding protein
WT1 Wilms tumor 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XYLB xylulokinase homolog (H. influenzae)
ZNF24 zinc finger protein 24
ZNF639 zinc finger protein 639
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ALPK1 alpha-kinase 1
ANKRD36 ankyrin repeat domain 36
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ATG10 autophagy related 10
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CBX8 chromobox homolog 8
CCNE1 cyclin E1
CD101 CD101 molecule
CD53 CD53 molecule
CFAP45 cilia and flagella associated protein 45
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CPNE7 copine VII
CRMP1 collapsin response mediator protein 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNM3 dynamin 3
DOC2A double C2-like domains, alpha
EFNB1 ephrin-B1
FAM120C family with sequence similarity 120C
FBXW12 F-box and WD repeat domain containing 12
FLT4 fms-related tyrosine kinase 4
FZD10 frizzled class receptor 10
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLB1L galactosidase, beta 1-like
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GSTM5 glutathione S-transferase mu 5
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HAUS2 HAUS augmin-like complex, subunit 2
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H2BM histone cluster 1, H2bm
HIST1H4C histone cluster 1, H4c
HOXC11 homeobox C11
IFI6 interferon, alpha-inducible protein 6
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL2 interleukin 2
IL24 interleukin 24
ITPKC inositol-trisphosphate 3-kinase C
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA0894 KIAA0894 protein
KIRREL kin of IRRE like (Drosophila)
KLHL28 kelch-like family member 28
LAMC3 laminin, gamma 3
LIMS2 LIM and senescent cell antigen-like domains 2
LINC00115 long intergenic non-protein coding RNA 115
LRRC6 leucine rich repeat containing 6
LYRM9 LYR motif containing 9
MBTD1 mbt domain containing 1
MDM4 MDM4, p53 regulator
MED18 mediator complex subunit 18
MFGE8 milk fat globule-EGF factor 8 protein
MTA2 metastasis associated 1 family, member 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NID2 nidogen 2 (osteonidogen)
OSGIN1 oxidative stress induced growth inhibitor 1
PADI1 peptidyl arginine deiminase, type I
PLSCR2 phospholipid scramblase 2
POLL polymerase (DNA directed), lambda
POM121L2 POM121 transmembrane nucleoporin-like 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRR14L proline rich 14-like
RAB3A RAB3A, member RAS oncogene family
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBBP5 retinoblastoma binding protein 5
RFPL1S RFPL1 antisense RNA 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RPGRIP1L RPGRIP1-like
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A8 solute carrier family 12, member 8
SLC22A14 solute carrier family 22, member 14
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNRPN small nuclear ribonucleoprotein polypeptide N
SPIN1 spindlin 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAOK1 TAO kinase 1
TCP11 t-complex 11, testis-specific
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEP1 telomerase-associated protein 1
TLN1 talin 1
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF264 zinc finger protein 264
ZNF652 zinc finger protein 652
ZNF669 zinc finger protein 669
ZNF721 zinc finger protein 721