spiradoline-3901 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the spiradoline-3901 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ADAM20 ADAM metallopeptidase domain 20
ADM adrenomedullin
ADRA2B adrenoceptor alpha 2B
AHNAK AHNAK nucleoprotein
AKR1C1 aldo-keto reductase family 1, member C1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARL3 ADP-ribosylation factor-like 3
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
C18ORF25 chromosome 18 open reading frame 25
C3AR1 complement component 3a receptor 1
CABP2 calcium binding protein 2
CAMK1G calcium/calmodulin-dependent protein kinase IG
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CDC25C cell division cycle 25C
CEP152 centrosomal protein 152kDa
CLSTN2 calsyntenin 2
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNOT4 CCR4-NOT transcription complex, subunit 4
CPEB3 cytoplasmic polyadenylation element binding protein 3
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DLC1 DLC1 Rho GTPase activating protein
DRD2 dopamine receptor D2
EFNA5 ephrin-A5
FAM63B family with sequence similarity 63, member B
FAM76A family with sequence similarity 76, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR1 fibroblast growth factor receptor 1
FOXP3 forkhead box P3
GCKR glucokinase (hexokinase 4) regulator
GFER growth factor, augmenter of liver regeneration
GJA4 gap junction protein, alpha 4, 37kDa
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GRIK5 glutamate receptor, ionotropic, kainate 5
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HOXA10 homeobox A10
HYAL3 hyaluronoglucosaminidase 3
IGHA1 immunoglobulin heavy constant alpha 1
IL25 interleukin 25
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA0368 KIAA0368
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LIMS2 LIM and senescent cell antigen-like domains 2
LSP1 lymphocyte-specific protein 1
LY9 lymphocyte antigen 9
LYZL6 lysozyme-like 6
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MED16 mediator complex subunit 16
MON2 MON2 homolog (S. cerevisiae)
MPP1 membrane protein, palmitoylated 1, 55kDa
MXRA8 matrix-remodelling associated 8
NECAB2 N-terminal EF-hand calcium binding protein 2
NELL2 NEL-like 2 (chicken)
NMT2 N-myristoyltransferase 2
NPY1R neuropeptide Y receptor Y1
NUP54 nucleoporin 54kDa
NYNRIN NYN domain and retroviral integrase containing
PACS1 phosphofurin acidic cluster sorting protein 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE10A phosphodiesterase 10A
PDE9A phosphodiesterase 9A
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POU2F3 POU class 2 homeobox 3
PTCH1 patched 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
REM1 RAS (RAD and GEM)-like GTP-binding 1
RIOK3 RIO kinase 3
RNF17 ring finger protein 17
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SERHL2 serine hydrolase-like 2
SIRT5 sirtuin 5
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOS2 son of sevenless homolog 2 (Drosophila)
SRPK3 SRSF protein kinase 3
STAT2 signal transducer and activator of transcription 2, 113kDa
STK17B serine/threonine kinase 17b
SUN1 Sad1 and UNC84 domain containing 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TECTA tectorin alpha
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNPO2 transportin 2
TTLL5 tubulin tyrosine ligase-like family member 5
TUBA4B tubulin, alpha 4b
UBR4 ubiquitin protein ligase E3 component n-recognin 4
ZBED4 zinc finger, BED-type containing 4
ZBTB33 zinc finger and BTB domain containing 33
ZNF235 zinc finger protein 235
ZNF507 zinc finger protein 507
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALOX12 arachidonate 12-lipoxygenase
AXIN1 axin 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BIRC7 baculoviral IAP repeat containing 7
C8ORF44 chromosome 8 open reading frame 44
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC71 coiled-coil domain containing 71
CCDC9 coiled-coil domain containing 9
CCNO cyclin O
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLCN2 chloride channel, voltage-sensitive 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRY2 cryptochrome circadian clock 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DBF4B DBF4 zinc finger B
DGAT1 diacylglycerol O-acyltransferase 1
DMTN dematin actin binding protein
DPY19L1P1 DPY19L1 pseudogene 1
DRD1 dopamine receptor D1
DUSP9 dual specificity phosphatase 9
EGFL7 EGF-like-domain, multiple 7
ENO3 enolase 3 (beta, muscle)
FGL1 fibrinogen-like 1
FRMD1 FERM domain containing 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GLS2 glutaminase 2 (liver, mitochondrial)
GMPR guanosine monophosphate reductase
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HIST1H2AI histone cluster 1, H2ai
HIST1H2BM histone cluster 1, H2bm
HSF4 heat shock transcription factor 4
HSPA1L heat shock 70kDa protein 1-like
HYI hydroxypyruvate isomerase (putative)
IL22 interleukin 22
IRF2BP1 interferon regulatory factor 2 binding protein 1
KDM5C lysine (K)-specific demethylase 5C
KIAA0125 KIAA0125
KIF13B kinesin family member 13B
KLK8 kallikrein-related peptidase 8
LOC390998 ribosomal protein L10 pseudogene
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPK10 mitogen-activated protein kinase 10
MAST3 microtubule associated serine/threonine kinase 3
MFGE8 milk fat globule-EGF factor 8 protein
MMP2 matrix metallopeptidase 2
MUC3A mucin 3A, cell surface associated
MUC3B mucin 3B, cell surface associated
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NKX3-2 NK3 homeobox 2
NPPA natriuretic peptide A
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCDHGA8 protocadherin gamma subfamily A, 8
PICK1 protein interacting with PRKCA 1
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNB3 plexin B3
PMCH pro-melanin-concentrating hormone
PYCRL pyrroline-5-carboxylate reductase-like
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RHOBTB2 Rho-related BTB domain containing 2
RNF39 ring finger protein 39
S100A4 S100 calcium binding protein A4
SERGEF secretion regulating guanine nucleotide exchange factor
SH3D21 SH3 domain containing 21
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMIM14 small integral membrane protein 14
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOAT2 sterol O-acyltransferase 2
SPON2 spondin 2, extracellular matrix protein
SPTBN2 spectrin, beta, non-erythrocytic 2
STK16 serine/threonine kinase 16
SYNC syncoilin, intermediate filament protein
TARP TCR gamma alternate reading frame protein
TBX19 T-box 19
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC22D4 TSC22 domain family, member 4
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
VIM vimentin
VIPR1 vasoactive intestinal peptide receptor 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
ZBED1 zinc finger, BED-type containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZIC3 Zic family member 3
ZNF41 zinc finger protein 41