spindle Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. (Gene Ontology, GO_0005819)
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Genes

314 genes co-occuring with the biological term spindle in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
AFAP1L1 actin filament associated protein 1-like 1
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC15 anaphase promoting complex subunit 15
ANO1 anoctamin 1, calcium activated chloride channel
APC adenomatous polyposis coli
APP amyloid beta (A4) precursor protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARR3 arrestin 3, retinal (X-arrestin)
ARRB2 arrestin, beta 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATM ATM serine/threonine kinase
AUNIP aurora kinase A and ninein interacting protein
AURKA aurora kinase A
AURKB aurora kinase B
AURKC aurora kinase C
BECN1 beclin 1, autophagy related
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CASC5 cancer susceptibility candidate 5
CCNA2 cyclin A2
CCNB1 cyclin B1
CD163 CD163 molecule
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CD99 CD99 molecule
CDC14B cell division cycle 14B
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC25C cell division cycle 25C
CDC27 cell division cycle 27
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDCA5 cell division cycle associated 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK11A cyclin-dependent kinase 11A
CDK2 cyclin-dependent kinase 2
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPI centromere protein I
CENPJ centromere protein J
CENPT centromere protein T
CEP170 centrosomal protein 170kDa
CEP192 centrosomal protein 192kDa
CEP57 centrosomal protein 57kDa
CEP70 centrosomal protein 70kDa
CHEK1 checkpoint kinase 1
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CIT citron rho-interacting serine/threonine kinase
CKAP2L cytoskeleton associated protein 2-like
CKAP5 cytoskeleton associated protein 5
CKS1B CDC28 protein kinase regulatory subunit 1B
CLASP1 cytoplasmic linker associated protein 1
CLIP1 CAP-GLY domain containing linker protein 1
CLTC clathrin, heavy chain (Hc)
CNTROB centrobin, centrosomal BRCA2 interacting protein
CSNK1D casein kinase 1, delta
CSPP1 centrosome and spindle pole associated protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUEDC2 CUE domain containing 2
CUL1 cullin 1
CYLD cylindromatosis (turban tumor syndrome)
DCLRE1B DNA cross-link repair 1B
DCTN1 dynactin 1
DCX doublecortin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL3 dihydropyrimidinase-like 3
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYNLL1 dynein, light chain, LC8-type 1
ECT2 epithelial cell transforming 2
EFHC1 EF-hand domain (C-terminal) containing 1
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF3E eukaryotic translation initiation factor 3, subunit E
EPB41 erythrocyte membrane protein band 4.1
EPN1 epsin 1
ERCC3 excision repair cross-complementation group 3
ERCC6L excision repair cross-complementation group 6-like
EWSR1 EWS RNA-binding protein 1
FAM110A family with sequence similarity 110, member A
FAM110B family with sequence similarity 110, member B
FBXO5 F-box protein 5
FLCN folliculin
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FMN2 formin 2
FRY furry homolog (Drosophila)
FXYD5 FXYD domain containing ion transport regulator 5
FYN FYN proto-oncogene, Src family tyrosine kinase
GAK cyclin G associated kinase
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN2 gem (nuclear organelle) associated protein 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GORASP1 golgi reassembly stacking protein 1, 65kDa
GPSM2 G-protein signaling modulator 2
GSG2 germ cell associated 2 (haspin)
GSK3B glycogen synthase kinase 3 beta
HAUS1 HAUS augmin-like complex, subunit 1
HAUS6 HAUS augmin-like complex, subunit 6
HAUS8 HAUS augmin-like complex, subunit 8
HIP1R huntingtin interacting protein 1 related
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNF1B HNF1 homeobox B
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HRAS Harvey rat sarcoma viral oncogene homolog
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IK IK cytokine, down-regulator of HLA II
ILK integrin-linked kinase
INCENP inner centromere protein antigens 135/155kDa
INO80 INO80 complex subunit
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KATNAL1 katanin p60 subunit A-like 1
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF1C kinesin family member 1C
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KIF2A kinesin heavy chain member 2A
KIF2B kinesin family member 2B
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIF9 kinesin family member 9
KIFC1 kinesin family member C1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KNSTRN kinetochore-localized astrin/SPAG5 binding protein
KPNB1 karyopherin (importin) beta 1
KRT4 keratin 4, type II
KRT7 keratin 7, type II
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LMNB1 lamin B1
LMNB2 lamin B2
LRRCC1 leucine rich repeat and coiled-coil centrosomal protein 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L1BP MAD2L1 binding protein
MAP1S microtubule-associated protein 1S
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP4 microtubule-associated protein 4
MAP9 microtubule-associated protein 9
MAPK14 mitogen-activated protein kinase 14
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARK2 MAP/microtubule affinity-regulating kinase 2
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MIR200A microRNA 200a
MIR200B microRNA 200b
MIR200C microRNA 200c
MIR205 microRNA 205
MISP mitotic spindle positioning
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MOB1A MOB kinase activator 1A
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYOD1 myogenic differentiation 1
NCAM1 neural cell adhesion molecule 1
NCL nucleolin
NCOA2 nuclear receptor coactivator 2
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NDEL1 nudE neurodevelopment protein 1-like 1
NEDD1 neural precursor cell expressed, developmentally down-regulated 1
NEK2 NIMA-related kinase 2
NEK7 NIMA-related kinase 7
NEK9 NIMA-related kinase 9
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NGFR nerve growth factor receptor
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NTF3 neurotrophin 3
NUDC nudC nuclear distribution protein
NUMA1 nuclear mitotic apparatus protein 1
NUP107 nucleoporin 107kDa
NUP153 nucleoporin 153kDa
NUP160 nucleoporin 160kDa
NUP62 nucleoporin 62kDa
NUSAP1 nucleolar and spindle associated protein 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARD3 par-3 family cell polarity regulator
PARD6B par-6 family cell polarity regulator beta
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP3 poly (ADP-ribose) polymerase family, member 3
PCNT pericentrin
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPN podoplanin
PEBP1 phosphatidylethanolamine binding protein 1
PGR progesterone receptor
PGRMC1 progesterone receptor membrane component 1
PIAS4 protein inhibitor of activated STAT, 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PLK3 polo-like kinase 3
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
PPP6C protein phosphatase 6, catalytic subunit
PRC1 protein regulator of cytokinesis 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCI protein kinase C, iota
PROX1 prospero homeobox 1
PRPF4 pre-mRNA processing factor 4
PSIP1 PC4 and SFRS1 interacting protein 1
PSRC1 proline/serine-rich coiled-coil 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTMA prothymosin, alpha
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAE1 ribonucleic acid export 1
RAN RAN, member RAS oncogene family
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RB1 retinoblastoma 1
RBM14 RNA binding motif protein 14
RCC1 regulator of chromosome condensation 1
RHOA ras homolog family member A
RIC8A RIC8 guanine nucleotide exchange factor A
RPS3 ribosomal protein S3
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A1 S100 calcium binding protein A1
S100A6 S100 calcium binding protein A6
SBDS Shwachman-Bodian-Diamond syndrome
SEPT12 septin 12
SEPT7 septin 7
SGOL1 shugoshin-like 1 (S. pombe)
SHCBP1L SHC SH2-domain binding protein 1-like
SIRT1 sirtuin 1
SIRT3 sirtuin 3
SKA1 spindle and kinetochore associated complex subunit 1
SKA2 spindle and kinetochore associated complex subunit 2
SKA3 spindle and kinetochore associated complex subunit 3
SKP1 S-phase kinase-associated protein 1
SLK STE20-like kinase
SMC1A structural maintenance of chromosomes 1A
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SPAG5 sperm associated antigen 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPIN1 spindlin 1
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSRP1 structure specific recognition protein 1
STIL SCL/TAL1 interrupting locus
STIM1 stromal interaction molecule 1
STMN1 stathmin 1
SUMO1 small ubiquitin-like modifier 1
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SYMPK symplekin
TACC2 transforming, acidic coiled-coil containing protein 2
TACC3 transforming, acidic coiled-coil containing protein 3
TAOK1 TAO kinase 1
TBCB tubulin folding cofactor B
TBCD tubulin folding cofactor D
TERT telomerase reverse transcriptase
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM201 transmembrane protein 201
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TOP3A topoisomerase (DNA) III alpha
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPP2 tripeptidyl peptidase II
TPPP tubulin polymerization promoting protein
TPR translocated promoter region, nuclear basket protein
TPX2 TPX2, microtubule-associated
TRIOBP TRIO and F-actin binding protein
TROAP trophinin associated protein
TTC1 tetratricopeptide repeat domain 1
TTK TTK protein kinase
TTN titin
TUBA1B tubulin, alpha 1b
TUBG1 tubulin, gamma 1
TUBGCP5 tubulin, gamma complex associated protein 5
TWIST1 twist family bHLH transcription factor 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP39 ubiquitin specific peptidase 39
VASP vasodilator-stimulated phosphoprotein
WDR62 WD repeat domain 62
WT1 Wilms tumor 1
XPO1 exportin 1
ZWINT ZW10 interacting kinetochore protein