spindle pole Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. (Gene Ontology, GO_0000922)
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Genes

318 proteins co-occuring with the spindle pole cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
NUMA1 nuclear mitotic apparatus protein 1 2.25586
SFTPB surfactant protein B 2.22617
PROS2P protein S (beta) pseudogene 1.88072
SFTPC surfactant protein C 1.77731
PLK1 polo-like kinase 1 1.70568
KIF11 kinesin family member 11 1.65272
NKX2-1 NK2 homeobox 1 1.6001
TPX2 TPX2, microtubule-associated 1.54631
AURKB aurora kinase B 1.53049
DCTN1 dynactin 1 1.47796
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 1.47004
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.46552
CKAP5 cytoskeleton associated protein 5 1.40075
CDC14A cell division cycle 14A 1.326
CNTLN centlein, centrosomal protein 1.30927
SFTPA1 surfactant protein A1 1.29103
PCNT pericentrin 1.2825
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) 1.25338
CSPP1 centrosome and spindle pole associated protein 1 1.16491
CDK1 cyclin-dependent kinase 1 1.15467
CENPE centromere protein E, 312kDa 1.14801
TUBGCP2 tubulin, gamma complex associated protein 2 1.11123
FGF7 fibroblast growth factor 7 1.0873
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 1.08222
KIF15 kinesin family member 15 1.03829
PLK3 polo-like kinase 3 1.0253
TACC3 transforming, acidic coiled-coil containing protein 3 1.0238
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 1.02281
BAG2 BCL2-associated athanogene 2 0.998086
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.996613
WDR62 WD repeat domain 62 0.987317
KIF2C kinesin family member 2C 0.962627
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.962627
HAUS8 HAUS augmin-like complex, subunit 8 0.960707
NEK9 NIMA-related kinase 9 0.940215
NEK6 NIMA-related kinase 6 0.934544
INCENP inner centromere protein antigens 135/155kDa 0.933601
BAG1 BCL2-associated athanogene 0.928892
CDC20 cell division cycle 20 0.90739
CCDC59 coiled-coil domain containing 59 0.904602
TUBA1A tubulin, alpha 1a 0.896257
PLK2 polo-like kinase 2 0.887474
SFTPA2 surfactant protein A2 0.887012
CETN2 centrin, EF-hand protein, 2 0.863528
SPDL1 spindle apparatus coiled-coil protein 1 0.856176
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 0.855717
BUB3 BUB3 mitotic checkpoint protein 0.847451
CCP110 centriolar coiled coil protein 110kDa 0.839646
NDC80 NDC80 kinetochore complex component 0.806606
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.80523
KIF2A kinesin heavy chain member 2A 0.803396
AURKA aurora kinase A 0.793313
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.789649
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.779126
DNAH14 dynein, axonemal, heavy chain 14 0.774558
DNAH12 dynein, axonemal, heavy chain 12 0.774558
NUF2 NUF2, NDC80 kinetochore complex component 0.770451
CENPF centromere protein F, 350/400kDa 0.761797
NEK2 NIMA-related kinase 2 0.760887
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.758615
DNAH5 dynein, axonemal, heavy chain 5 0.74322
NUDC nudC nuclear distribution protein 0.73018
MEI1 meiosis inhibitor 1 0.719906
CDC27 cell division cycle 27 0.715014
CETN1 centrin, EF-hand protein, 1 0.709693
MAP4 microtubule-associated protein 4 0.699103
NIN ninein (GSK3B interacting protein) 0.678978
CCNB1 cyclin B1 0.678543
MSMB microseminoprotein, beta- 0.678543
DNAH9 dynein, axonemal, heavy chain 9 0.676803
KIF4A kinesin family member 4A 0.67463
DCTN2 dynactin 2 (p50) 0.669425
TACC1 transforming, acidic coiled-coil containing protein 1 0.663368
ZW10 zw10 kinetochore protein 0.662072
FAM110A family with sequence similarity 110, member A 0.660345
FAM110B family with sequence similarity 110, member B 0.660345
NEK7 NIMA-related kinase 7 0.65345
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.648721
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.648291
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.647862
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.636295
RAB40AL RAB40A, member RAS oncogene family-like 0.629465
KIF23 kinesin family member 23 0.62393
CLIP1 CAP-GLY domain containing linker protein 1 0.620104
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 0.61883
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 0.617133
CEP250 centrosomal protein 250kDa 0.615861
KIZ kizuna centrosomal protein 0.610778
SFTPD surfactant protein D 0.610355
C11ORF73 chromosome 11 open reading frame 73 0.609932
RAD21 RAD21 homolog (S. pombe) 0.608241
CENPJ centromere protein J 0.602331
HOXB5 homeobox B5 0.596855
CASC1 cancer susceptibility candidate 1 0.593072
SGOL1 shugoshin-like 1 (S. pombe) 0.587618
NUDCD2 NudC domain containing 2 0.585942
KIFC1 kinesin family member C1 0.583849
FGF10 fibroblast growth factor 10 0.577581
SECISBP2L SECIS binding protein 2-like 0.574244
MIS12 MIS12 kinetochore complex component 0.566754
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.558042
TNKS1BP1 tankyrase 1 binding protein 1, 182kDa 0.557629
CEP192 centrosomal protein 192kDa 0.555973
AUNIP aurora kinase A and ninein interacting protein 0.555145
STIL SCL/TAL1 interrupting locus 0.541529
FAM110C family with sequence similarity 110, member C 0.53906
FMN1 formin 1 0.529208
FMN2 formin 2 0.523067
KIN Kin17 DNA and RNA binding protein 0.52225
MAP2 microtubule-associated protein 2 0.519798
KATNA1 katanin p60 (ATPase containing) subunit A 1 0.518981
APITD1 apoptosis-inducing, TAF9-like domain 1 0.516124
BIRC5 baculoviral IAP repeat containing 5 0.50879
MAPT microtubule-associated protein tau 0.507163
MPEG1 macrophage expressed 1 0.505944
TACC2 transforming, acidic coiled-coil containing protein 2 0.501881
RICTOR RPTOR independent companion of MTOR, complex 2 0.499042
SPO11 SPO11 meiotic protein covalently bound to DSB 0.498231
STK40 serine/threonine kinase 40 0.498231
MAD2L1P1 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene 1 0.496205
WRAP73 WD repeat containing, antisense to TP73 0.4958
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.49499
CDC7 cell division cycle 7 0.488115
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 0.486096
BORA bora, aurora kinase A activator 0.48287
TRIM69 tripartite motif containing 69 0.475223
CEP57 centrosomal protein 57kDa 0.472011
YPEL5 yippee-like 5 (Drosophila) 0.468401
SEPT1 septin 1 0.4676
TMEM33 transmembrane protein 33 0.465998
GOLGA7 golgin A7 0.461199
NME1-NME2 NME1-NME2 readthrough 0.460001
PLAGL2 pleiomorphic adenoma gene-like 2 0.460001
AQP5 aquaporin 5 0.460001
THUMPD1 THUMP domain containing 1 0.458006
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 0.458006
SPATC1 spermatogenesis and centriole associated 1 0.454816
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha 0.446465
FXYD1 FXYD domain containing ion transport regulator 1 0.434591
STARD9 StAR-related lipid transfer (START) domain containing 9 0.433801
NUDCD3 NudC domain containing 3 0.431829
OIT3 oncoprotein induced transcript 3 0.430647
CD248 CD248 molecule, endosialin 0.428284
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.427891
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.426318
PLK4 polo-like kinase 4 0.424353
BOD1 biorientation of chromosomes in cell division 1 0.424353
TTK TTK protein kinase 0.42396
TUBGCP4 tubulin, gamma complex associated protein 4 0.420036
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 0.420036
SAC3D1 SAC3 domain containing 1 0.419252
CDC34 cell division cycle 34 0.414164
CDCA4 cell division cycle associated 4 0.403637
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.400916
FBXO5 F-box protein 5 0.398975
PPP1R7 protein phosphatase 1, regulatory subunit 7 0.394323
SPC24 SPC24, NDC80 kinetochore complex component 0.390841
MORN1 MORN repeat containing 1 0.389296
MCRS1 microspherule protein 1 0.388909
EPB41 erythrocyte membrane protein band 4.1 0.388523
MZT1 mitotic spindle organizing protein 1 0.388523
MPPE1 metallophosphoesterase 1 0.387751
NDEL1 nudE neurodevelopment protein 1-like 1 0.382354
ASPRV1 aspartic peptidase, retroviral-like 1 0.380814
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.378122
KIF18B kinesin family member 18B 0.371599
STK3 serine/threonine kinase 3 0.370833
FAM161B family with sequence similarity 161, member B 0.367388
ECT2 epithelial cell transforming 2 0.366623
PCDHGA10 protocadherin gamma subfamily A, 10 0.366241
YEATS4 YEATS domain containing 4 0.365859
CEP55 centrosomal protein 55kDa 0.361659
SPAG5 sperm associated antigen 5 0.360896
POC1B POC1 centriolar protein B 0.359752
NEK11 NIMA-related kinase 11 0.357847
CEP162 centrosomal protein 162kDa 0.356705
AMT aminomethyltransferase 0.347208
LRRC38 leucine rich repeat containing 38 0.347208
POC1A POC1 centriolar protein A 0.347208
CEP152 centrosomal protein 152kDa 0.345692
ZWILCH zwilch kinetochore protein 0.345314
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.343799
KIF12 kinesin family member 12 0.340773
STK26 serine/threonine protein kinase 26 0.340395
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.337751
TUBB tubulin, beta class I 0.334356
SMC3 structural maintenance of chromosomes 3 0.333602
KATNB1 katanin p80 (WD repeat containing) subunit B 1 0.333225
XPO1 exportin 1 0.332848
NUP188 nucleoporin 188kDa 0.330213
FGF18 fibroblast growth factor 18 0.325702
AHCTF1 AT hook containing transcription factor 1 0.315586
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.312224
RANBP1 RAN binding protein 1 0.310732
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.308122
ALB albumin 0.301797
GPC2 glypican 2 0.298455
DNAAF1 dynein, axonemal, assembly factor 1 0.298084
AOAH acyloxyacyl hydrolase (neutrophil) 0.296972
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.29623
SPAST spastin 0.289938
AURKC aurora kinase C 0.289199
CCNB3 cyclin B3 0.28846
CETN3 centrin, EF-hand protein, 3 0.287352
OLA1 Obg-like ATPase 1 0.286245
DYNLT1 dynein, light chain, Tctex-type 1 0.284032
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.283295
EPT1 ethanolaminephosphotransferase 1 0.281821
TROAP trophinin associated protein 0.279612
STK11 serine/threonine kinase 11 0.278877
CNN2 calponin 2 0.277774
SEPT7 septin 7 0.276671
SUMO1 small ubiquitin-like modifier 1 0.275202
BRCA1 breast cancer 1, early onset 0.273734
CKAP2 cytoskeleton associated protein 2 0.273367
GMDS GDP-mannose 4,6-dehydratase 0.2719
ACTG1 actin gamma 1 0.271533
RAE1 ribonucleic acid export 1 0.271533
TP53 tumor protein p53 0.270434
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.269701
MID1 midline 1 0.268969
GPSM2 G-protein signaling modulator 2 0.266774
LIMK2 LIM domain kinase 2 0.265311
PARP1 poly (ADP-ribose) polymerase 1 0.264581
NT5C 5', 3'-nucleotidase, cytosolic 0.26312
DYNLT3 dynein, light chain, Tctex-type 3 0.26239
RMDN3 regulator of microtubule dynamics 3 0.26239
RANBP10 RAN binding protein 10 0.260566
CAPN5 calpain 5 0.258745
FGF1 fibroblast growth factor 1 (acidic) 0.258016
SP3 Sp3 transcription factor 0.255834
KIAA1524 KIAA1524 0.255834
LIMK1 LIM domain kinase 1 0.252202
IK IK cytokine, down-regulator of HLA II 0.243879
TEKT2 tektin 2 (testicular) 0.242076
STMN1 stathmin 1 0.241356
NIM1K NIM1 serine/threonine protein kinase 0.240276
ACTB actin, beta 0.239916
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 0.239916
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 0.238837
MAP2K1 mitogen-activated protein kinase kinase 1 0.237401
FIGN fidgetin 0.236324
ANLN anillin, actin binding protein 0.235607
HAUS6 HAUS augmin-like complex, subunit 6 0.233817
DIAPH3 diaphanous-related formin 3 0.229176
HOXA4 homeobox A4 0.229176
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.227397
NUP37 nucleoporin 37kDa 0.224558
ASF1B anti-silencing function 1B histone chaperone 0.224558
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.219969
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.217511
H3F3A H3 histone, family 3A 0.21681
H3F3B H3 histone, family 3B (H3.3B) 0.21681
PARD6A par-6 family cell polarity regulator alpha 0.207451
TAOK1 TAO kinase 1 0.203361
NUAK1 NUAK family, SNF1-like kinase, 1 0.198991
FYN FYN proto-oncogene, Src family tyrosine kinase 0.195681
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.194698
KPTN kaptin (actin binding protein) 0.194698
PTTG1 pituitary tumor-transforming 1 0.194045
UBE2S ubiquitin-conjugating enzyme E2S 0.192746
HOXB8 homeobox B8 0.192423
CASC5 cancer susceptibility candidate 5 0.191777
FOXM1 forkhead box M1 0.191777
MMP10 matrix metallopeptidase 10 0.191135
CENPW centromere protein W 0.188905
RAN RAN, member RAS oncogene family 0.186087
TLK1 tousled-like kinase 1 0.183631
TDRD7 tudor domain containing 7 0.183631
BARD1 BRCA1 associated RING domain 1 0.182422
ITGB1BP1 integrin beta 1 binding protein 1 0.182422
DDX11L8 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 like 8 0.180634
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.180045
GPR176 G protein-coupled receptor 176 0.180045
CDCA8 cell division cycle associated 8 0.179752
KIF14 kinesin family member 14 0.179459
FOXF1 forkhead box F1 0.179167
NEK1 NIMA-related kinase 1 0.177724
TNF tumor necrosis factor 0.17687
BRAP BRCA1 associated protein 0.175745
STK38 serine/threonine kinase 38 0.173543
UBE2K ubiquitin-conjugating enzyme E2K 0.171937
TUBD1 tubulin, delta 1 0.171673
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 0.170888
NINL ninein-like 0.170114
EFHC1 EF-hand domain (C-terminal) containing 1 0.169099
NDE1 nudE neurodevelopment protein 1 0.167856
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.167856
PDPN podoplanin 0.167611
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) 0.167366
IL1A interleukin 1, alpha 0.165697
NUP107 nucleoporin 107kDa 0.163641
SCD5 stearoyl-CoA desaturase 5 0.16298
GPR162 G protein-coupled receptor 162 0.162546
FASN fatty acid synthase 0.160863
CC2D1A coiled-coil and C2 domain containing 1A 0.160456
NCOA2 nuclear receptor coactivator 2 0.159268
RANGAP1 Ran GTPase activating protein 1 0.158502
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 0.157397
FOXA1 forkhead box A1 0.156863
NPHP1 nephronophthisis 1 (juvenile) 0.14938
SENP1 SUMO1/sentrin specific peptidase 1 0.149017
RAB6A RAB6A, member RAS oncogene family 0.147834
LNPEP leucyl/cystinyl aminopeptidase 0.143641
VDAC3 voltage-dependent anion channel 3 0.143624
STX8 syntaxin 8 0.143559
MYH10 myosin, heavy chain 10, non-muscle 0.143495
CNN1 calponin 1, basic, smooth muscle 0.142741
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.142685
MYO10 myosin X 0.142398
FGFR1 fibroblast growth factor receptor 1 0.142341
UMOD uromodulin 0.141265
KIF3A kinesin family member 3A 0.140308
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.139701
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.139549
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.139212
RANBP2 RAN binding protein 2 0.138049
CAPN2 calpain 2, (m/II) large subunit 0.136151