spectinomycin-4187 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the spectinomycin-4187 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACOT11 acyl-CoA thioesterase 11
ADAM12 ADAM metallopeptidase domain 12
ADCY2 adenylate cyclase 2 (brain)
ADGRL3 adhesion G protein-coupled receptor L3
AHNAK AHNAK nucleoprotein
AKAP5 A kinase (PRKA) anchor protein 5
ANKLE2 ankyrin repeat and LEM domain containing 2
AOC3 amine oxidase, copper containing 3
ARTN artemin
ASMTL acetylserotonin O-methyltransferase-like
ATXN7L1 ataxin 7-like 1
B3GAT1 beta-1,3-glucuronyltransferase 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BBC3 BCL2 binding component 3
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF95 chromosome 10 open reading frame 95
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD22 CD22 molecule
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
COL4A6 collagen, type IV, alpha 6
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CREBZF CREB/ATF bZIP transcription factor
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CRY2 cryptochrome circadian clock 2
CXCL5 chemokine (C-X-C motif) ligand 5
DMBT1 deleted in malignant brain tumors 1
DOK4 docking protein 4
DTNA dystrobrevin, alpha
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FANCA Fanconi anemia, complementation group A
FRMD4B FERM domain containing 4B
FRS2 fibroblast growth factor receptor substrate 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GJA4 gap junction protein, alpha 4, 37kDa
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GPATCH4 G patch domain containing 4
HBS1L HBS1-like translational GTPase
HCRP1 hepatocellular carcinoma-related HCRP1
HOMER3 homer scaffolding protein 3
HRASLS2 HRAS-like suppressor 2
HSF2BP heat shock transcription factor 2 binding protein
IFI27 interferon, alpha-inducible protein 27
IL11 interleukin 11
IL36G interleukin 36, gamma
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KCNK10 potassium channel, two pore domain subfamily K, member 10
LOXL2 lysyl oxidase-like 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MMP9 matrix metallopeptidase 9
MOCS1 molybdenum cofactor synthesis 1
MST1 macrophage stimulating 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NF2 neurofibromin 2 (merlin)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOD1 nucleotide-binding oligomerization domain containing 1
NUP50 nucleoporin 50kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDLIM5 PDZ and LIM domain 5
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLK3 polo-like kinase 3
PPARD peroxisome proliferator-activated receptor delta
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PVR poliovirus receptor
RAB36 RAB36, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1 retinoblastoma 1
RPL35A ribosomal protein L35a
RPS14 ribosomal protein S14
RXRB retinoid X receptor, beta
SEC14L2 SEC14-like 2 (S. cerevisiae)
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRSF1 serine/arginine-rich splicing factor 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TBC1D2B TBC1 domain family, member 2B
TBC1D30 TBC1 domain family, member 30
TFEC transcription factor EC
TLE4 transducin-like enhancer of split 4
TNIK TRAF2 and NCK interacting kinase
UBE3A ubiquitin protein ligase E3A
UPK1B uroplakin 1B
WSB1 WD repeat and SOCS box containing 1
ZBTB20 zinc finger and BTB domain containing 20
ZMIZ2 zinc finger, MIZ-type containing 2
ZMYM5 zinc finger, MYM-type 5
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ACVR2B activin A receptor, type IIB
ADAM2 ADAM metallopeptidase domain 2
ADAM23 ADAM metallopeptidase domain 23
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANXA10 annexin A10
ANXA2P1 annexin A2 pseudogene 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARL14 ADP-ribosylation factor-like 14
ARRB2 arrestin, beta 2
C14ORF105 chromosome 14 open reading frame 105
C16ORF59 chromosome 16 open reading frame 59
C1R complement component 1, r subcomponent
C8A complement component 8, alpha polypeptide
CA11 carbonic anhydrase XI
CAPN15 calpain 15
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASS4 Cas scaffolding protein family member 4
CASZ1 castor zinc finger 1
CBX8 chromobox homolog 8
CCDC106 coiled-coil domain containing 106
CD68 CD68 molecule
CENPO centromere protein O
CGREF1 cell growth regulator with EF-hand domain 1
CHML choroideremia-like (Rab escort protein 2)
CLEC2B C-type lectin domain family 2, member B
CNN1 calponin 1, basic, smooth muscle
CORO1A coronin, actin binding protein, 1A
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DMTN dematin actin binding protein
DSPP dentin sialophosphoprotein
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
FKBP5 FK506 binding protein 5
FRMPD1 FERM and PDZ domain containing 1
GALK1 galactokinase 1
GSTA3 glutathione S-transferase alpha 3
HIST1H1D histone cluster 1, H1d
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BN histone cluster 1, H2bn
HIST1H3G histone cluster 1, H3g
HOXA6 homeobox A6
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFT140 intraflagellar transport 140
IL15RA interleukin 15 receptor, alpha
ITGB7 integrin, beta 7
KANSL3 KAT8 regulatory NSL complex subunit 3
KIAA1456 KIAA1456
KLF13 Kruppel-like factor 13
KRT20 keratin 20, type I
LIME1 Lck interacting transmembrane adaptor 1
LOC100287590 uncharacterized LOC100287590
LRP3 low density lipoprotein receptor-related protein 3
MTA2 metastasis associated 1 family, member 2
MTCP1 mature T-cell proliferation 1
MYOZ3 myozenin 3
NAT6 N-acetyltransferase 6 (GCN5-related)
NECAB3 N-terminal EF-hand calcium binding protein 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PCDH12 protocadherin 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLBD1 phospholipase B domain containing 1
PRSS53 protease, serine, 53
RAB11B RAB11B, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RUNDC3B RUN domain containing 3B
SCEL sciellin
SCGB2A2 secretoglobin, family 2A, member 2
SCIN scinderin
SETD8 SET domain containing (lysine methyltransferase) 8
SIRT6 sirtuin 6
SOX12 SRY (sex determining region Y)-box 12
SOX21 SRY (sex determining region Y)-box 21
SPATA1 spermatogenesis associated 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TIMP4 TIMP metallopeptidase inhibitor 4
TLN1 talin 1
TMPRSS4 transmembrane protease, serine 4
TPCN1 two pore segment channel 1
TSPAN2 tetraspanin 2
TUBA3C tubulin, alpha 3c
TUBG2 tubulin, gamma 2
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
XAB2 XPA binding protein 2
ZNF205 zinc finger protein 205
ZNF222 zinc finger protein 222
ZNF574 zinc finger protein 574