spectinomycin-2987 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the spectinomycin-2987 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
AGER advanced glycosylation end product-specific receptor
AMDHD2 amidohydrolase domain containing 2
ANKEF1 ankyrin repeat and EF-hand domain containing 1
APOA1 apolipoprotein A-I
APOD apolipoprotein D
APOE apolipoprotein E
ARTN artemin
ASPH aspartate beta-hydroxylase
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CCK cholecystokinin
CD300C CD300c molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CNOT4 CCR4-NOT transcription complex, subunit 4
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPN2 carboxypeptidase N, polypeptide 2
CREB3L1 cAMP responsive element binding protein 3-like 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25
DICER1 dicer 1, ribonuclease type III
DPEP2 dipeptidase 2
DSTYK dual serine/threonine and tyrosine protein kinase
DUX4L8 double homeobox 4 like 8
DXO decapping exoribonuclease
ELN elastin
EPAS1 endothelial PAS domain protein 1
FAM149A family with sequence similarity 149, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FCMR Fc fragment of IgM receptor
FGF17 fibroblast growth factor 17
GHRHR growth hormone releasing hormone receptor
GJA8 gap junction protein, alpha 8, 50kDa
GNMT glycine N-methyltransferase
GPR132 G protein-coupled receptor 132
GRM4 glutamate receptor, metabotropic 4
HAPLN1 hyaluronan and proteoglycan link protein 1
HTR7P1 5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
IFNA6 interferon, alpha 6
INS insulin
IQSEC1 IQ motif and Sec7 domain 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KDSR 3-ketodihydrosphingosine reductase
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LAMP1 lysosomal-associated membrane protein 1
LIMD2 LIM domain containing 2
LOC284244 uncharacterized LOC284244
LOXL3 lysyl oxidase-like 3
LRP2 low density lipoprotein receptor-related protein 2
MAP2K7 mitogen-activated protein kinase kinase 7
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP19 matrix metallopeptidase 19
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTSS1 metastasis suppressor 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NCOR2 nuclear receptor corepressor 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NHLH2 nescient helix loop helix 2
NIPAL3 NIPA-like domain containing 3
NOL10 nucleolar protein 10
NR2E3 nuclear receptor subfamily 2, group E, member 3
ONECUT2 one cut homeobox 2
PCDHGA8 protocadherin gamma subfamily A, 8
PDX1 pancreatic and duodenal homeobox 1
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PKD2L2 polycystic kidney disease 2-like 2
PLEK2 pleckstrin 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PRKG2 protein kinase, cGMP-dependent, type II
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCRL pyrroline-5-carboxylate reductase-like
RPS6 ribosomal protein S6
SH3D21 SH3 domain containing 21
SLC39A9 solute carrier family 39, member 9
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMC1A structural maintenance of chromosomes 1A
SOCS3 suppressor of cytokine signaling 3
SSH3 slingshot protein phosphatase 3
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TACR1 tachykinin receptor 1
TFR2 transferrin receptor 2
TMEM144 transmembrane protein 144
TMSB4Y thymosin beta 4, Y-linked
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNP2 transition protein 2 (during histone to protamine replacement)
TRPM1 transient receptor potential cation channel, subfamily M, member 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZBTB7B zinc finger and BTB domain containing 7B

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACPP acid phosphatase, prostate
ADORA3 adenosine A3 receptor
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ANO2 anoctamin 2, calcium activated chloride channel
ANXA2P3 annexin A2 pseudogene 3
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARG1 arginase 1
ARHGAP10 Rho GTPase activating protein 10
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BIRC3 baculoviral IAP repeat containing 3
C11ORF71 chromosome 11 open reading frame 71
C17ORF80 chromosome 17 open reading frame 80
C3ORF18 chromosome 3 open reading frame 18
CAMKMT calmodulin-lysine N-methyltransferase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC71 coiled-coil domain containing 71
CD37 CD37 molecule
CDR2L cerebellar degeneration-related protein 2-like
CEP295 centrosomal protein 295kDa
CLCN5 chloride channel, voltage-sensitive 5
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
COQ6 coenzyme Q6 monooxygenase
CRYGC crystallin, gamma C
CTAGE9 CTAGE family, member 9
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DNAL4 dynein, axonemal, light chain 4
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ETV4 ets variant 4
FBXL6 F-box and leucine-rich repeat protein 6
FXN frataxin
G6PD glucose-6-phosphate dehydrogenase
GFOD1 glucose-fructose oxidoreductase domain containing 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPATCH2L G patch domain containing 2-like
GPR35 G protein-coupled receptor 35
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNA14 interferon, alpha 14
IL12B interleukin 12B
ISOC2 isochorismatase domain containing 2
JPH3 junctophilin 3
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCTD20 potassium channel tetramerization domain containing 20
LIG4 ligase IV, DNA, ATP-dependent
LINC00260 long intergenic non-protein coding RNA 260
LTBP2 latent transforming growth factor beta binding protein 2
MAGEH1 melanoma antigen family H1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPKBP1 mitogen-activated protein kinase binding protein 1
MED15 mediator complex subunit 15
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MUC2 mucin 2, oligomeric mucus/gel-forming
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCKAP1L NCK-associated protein 1-like
PARP11 poly (ADP-ribose) polymerase family, member 11
PCSK7 proprotein convertase subtilisin/kexin type 7
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLA2G12A phospholipase A2, group XIIA
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PPT2 palmitoyl-protein thioesterase 2
PRO2964 uncharacterized protein PRO2964
RAB3A RAB3A, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPUSD2 RNA pseudouridylate synthase domain containing 2
SCRN3 secernin 3
SCRT1 scratch family zinc finger 1
SH2D4A SH2 domain containing 4A
SLC10A3 solute carrier family 10, member 3
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SYNC syncoilin, intermediate filament protein
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TCHH trichohyalin
THBS4 thrombospondin 4
TMEM209 transmembrane protein 209
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TXLNG taxilin gamma
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VNN1 vanin 1
VPREB1 pre-B lymphocyte 1
WDR76 WD repeat domain 76
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZFP30 ZFP30 zinc finger protein
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF155 zinc finger protein 155
ZNF254 zinc finger protein 254
ZNF480 zinc finger protein 480
ZNF747 zinc finger protein 747
ZNF85 zinc finger protein 85