specific granule Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. (Gene Ontology, GO_0042581)
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Genes

109 proteins co-occuring with the specific granule cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
LTF lactotransferrin 3.02366
MPO myeloperoxidase 2.02421
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 1.76045
EPX eosinophil peroxidase 1.74829
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 1.70383
RNASE3 ribonuclease, RNase A family, 3 1.62
LYZ lysozyme 1.42993
GUSB glucuronidase, beta 1.41586
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.39127
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 1.38073
NPPA natriuretic peptide A 1.33359
LCN2 lipocalin 2 1.25653
CLC Charcot-Leyden crystal galectin 1.18389
C5AR1 complement component 5a receptor 1 1.17824
ALPPL2 alkaline phosphatase, placental-like 2 1.07511
ALPL alkaline phosphatase, liver/bone/kidney 1.07461
ALPP alkaline phosphatase, placental 1.0741
CD63 CD63 molecule 1.06246
CTSG cathepsin G 1.05892
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 1.0398
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 1.03228
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1.01734
CAMP cathelicidin antimicrobial peptide 0.983419
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.968401
MMP8 matrix metallopeptidase 8 0.930304
BPI bactericidal/permeability-increasing protein 0.899036
IL5 interleukin 5 0.844237
ANXA3 annexin A3 0.780497
CD177 CD177 molecule 0.747737
ELANE elastase, neutrophil expressed 0.740064
ACPP acid phosphatase, prostate 0.726599
PNN pinin, desmosome associated protein 0.716791
CXCL8 chemokine (C-X-C motif) ligand 8 0.655602
ANXA11 annexin A11 0.650439
PRTN3 proteinase 3 0.643144
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 0.630745
FGR FGR proto-oncogene, Src family tyrosine kinase 0.615861
TNF tumor necrosis factor 0.579251
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.578833
PRG3 proteoglycan 3 0.577581
OLFM4 olfactomedin 4 0.575912
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.563017
SELL selectin L 0.558457
TF transferrin 0.541117
CYBA cytochrome b-245, alpha polypeptide 0.52716
HCK HCK proto-oncogene, Src family tyrosine kinase 0.525113
STX4 syntaxin 4 0.518573
RNASEH2A ribonuclease H2, subunit A 0.488923
CRISP3 cysteine-rich secretory protein 3 0.484079
CLEC3B C-type lectin domain family 3, member B 0.462798
DEFA4 defensin, alpha 4, corticostatin 0.4608
CXCR2 chemokine (C-X-C motif) receptor 2 0.460401
ANXA1 annexin A1 0.448848
SNAP23 synaptosomal-associated protein, 23kDa 0.441312
FPR1 formyl peptide receptor 1 0.432618
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.426711
PLA2G12A phospholipase A2, group XIIA 0.425138
PF4 platelet factor 4 0.414555
CUX1 cut-like homeobox 1 0.414555
CMA1 chymase 1, mast cell 0.409089
REN renin 0.367388
KLK8 kallikrein-related peptidase 8 0.365477
MMP9 matrix metallopeptidase 9 0.360896
PLA2G1B phospholipase A2, group IB (pancreas) 0.354802
CD34 CD34 molecule 0.354042
MMP25 matrix metallopeptidase 25 0.349863
CAT catalase 0.346071
B2M beta-2-microglobulin 0.338506
HPN hepsin 0.327581
STX3 syntaxin 3 0.315212
ADAM9 ADAM metallopeptidase domain 9 0.314839
GIF gastric intrinsic factor (vitamin B synthesis) 0.314091
HLX H2.0-like homeobox 0.312971
GCA grancalcin, EF-hand calcium binding protein 0.311105
CCL26 chemokine (C-C motif) ligand 26 0.283295
ALB albumin 0.275202
PLAUR plasminogen activator, urokinase receptor 0.271167
NOTCH3 notch 3 0.265677
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.265311
BPIFA1 BPI fold containing family A, member 1 0.259109
HLA-C major histocompatibility complex, class I, C 0.247492
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.243879
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.233101
FFAR2 free fatty acid receptor 2 0.218914
C5ORF38 chromosome 5 open reading frame 38 0.216111
HPSE heparanase 0.215761
HLA-A major histocompatibility complex, class I, A 0.213669
RAP1A RAP1A, member of RAS oncogene family 0.213322
NOTCH4 notch 4 0.209858
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.209513
ARSE arylsulfatase E (chondrodysplasia punctata 1) 0.206082
CCL24 chemokine (C-C motif) ligand 24 0.200999
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.199993
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.189857
ARSD arylsulfatase D 0.183631
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.180339
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.178011
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 0.177154
MALL mal, T-cell differentiation protein-like 0.174361
AZU1 azurocidin 1 0.172468
ACP2 acid phosphatase 2, lysosomal 0.170114
AMACR alpha-methylacyl-CoA racemase 0.166643
STXBP2 syntaxin binding protein 2 0.164089
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.162763
VAMP8 vesicle-associated membrane protein 8 0.162117
CYBB cytochrome b-245, beta polypeptide 0.161693
CD79A CD79a molecule, immunoglobulin-associated alpha 0.159658
CD48 CD48 molecule 0.159268
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.157578