sparteine-4391 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the sparteine-4391 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
AIM2 absent in melanoma 2
AKAP13 A kinase (PRKA) anchor protein 13
ANTXR1 anthrax toxin receptor 1
ARL4D ADP-ribosylation factor-like 4D
ASIC1 acid sensing (proton gated) ion channel 1
BMP8B bone morphogenetic protein 8b
C1ORF68 chromosome 1 open reading frame 68
C21ORF2 chromosome 21 open reading frame 2
C8A complement component 8, alpha polypeptide
CD83 CD83 molecule
CFHR4 complement factor H-related 4
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN11 claudin 11
COL6A1 collagen, type VI, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CUX2 cut-like homeobox 2
DCN decorin
DPP4 dipeptidyl-peptidase 4
EDN1 endothelin 1
EFHC2 EF-hand domain (C-terminal) containing 2
EXOSC2 exosome component 2
FMO3 flavin containing monooxygenase 3
FN1 fibronectin 1
FOXE1 forkhead box E1
FOXE3 forkhead box E3
FXYD5 FXYD domain containing ion transport regulator 5
GH1 growth hormone 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM2 glutamate receptor, metabotropic 2
HBEGF heparin-binding EGF-like growth factor
HEMK1 HemK methyltransferase family member 1
HFE hemochromatosis
HIST1H2BN histone cluster 1, H2bn
HIST1H4F histone cluster 1, H4f
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSF2BP heat shock transcription factor 2 binding protein
IGFBP5 insulin-like growth factor binding protein 5
IMPG2 interphotoreceptor matrix proteoglycan 2
ITGA7 integrin, alpha 7
ITM2C integral membrane protein 2C
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
LEFTY1 left-right determination factor 1
LOC100286895 cell division cycle 27 homolog pseudogene
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
MEF2D myocyte enhancer factor 2D
MEG3 maternally expressed 3 (non-protein coding)
MRC2 mannose receptor, C type 2
MYEF2 myelin expression factor 2
NPY neuropeptide Y
NTF3 neurotrophin 3
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PBX2 pre-B-cell leukemia homeobox 2
PCDH12 protocadherin 12
PILRA paired immunoglobin-like type 2 receptor alpha
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PNPLA3 patatin-like phospholipase domain containing 3
PON1 paraoxonase 1
PRODH2 proline dehydrogenase (oxidase) 2
PRTN3 proteinase 3
PTCRA pre T-cell antigen receptor alpha
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPRM protein tyrosine phosphatase, receptor type, M
RASIP1 Ras interacting protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHAG Rh-associated glycoprotein
RIF1 replication timing regulatory factor 1
RIN3 Ras and Rab interactor 3
RPS28 ribosomal protein S28
SEC24D SEC24 family member D
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH3BP2 SH3-domain binding protein 2
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX2 SRY (sex determining region Y)-box 2
SPEG SPEG complex locus
STK24 serine/threonine kinase 24
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TFDP3 transcription factor Dp family, member 3
TNPO2 transportin 2
TP53I11 tumor protein p53 inducible protein 11
TPP1 tripeptidyl peptidase I
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TTN titin
TUBB2B tubulin, beta 2B class IIb
VCAN versican
VNN2 vanin 2
VPS9D1 VPS9 domain containing 1
WFDC8 WAP four-disulfide core domain 8
ZNF362 zinc finger protein 362

decreased expression

Symbol Name
ACYP2 acylphosphatase 2, muscle type
AHNAK2 AHNAK nucleoprotein 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA2P3 annexin A2 pseudogene 3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
BGLAP bone gamma-carboxyglutamate (gla) protein
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTF3P12 basic transcription factor 3 pseudogene 12
C10ORF95 chromosome 10 open reading frame 95
C11ORF30 chromosome 11 open reading frame 30
C11ORF68 chromosome 11 open reading frame 68
C14ORF93 chromosome 14 open reading frame 93
C2ORF27A chromosome 2 open reading frame 27A
CASD1 CAS1 domain containing 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CHKB choline kinase beta
CNR2 cannabinoid receptor 2 (macrophage)
CRIP1 cysteine-rich protein 1 (intestinal)
DBF4B DBF4 zinc finger B
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKQ diacylglycerol kinase, theta 110kDa
DIXDC1 DIX domain containing 1
EDAR ectodysplasin A receptor
EGFL7 EGF-like-domain, multiple 7
ELOVL4 ELOVL fatty acid elongase 4
ERCC2 excision repair cross-complementation group 2
ETAA1 Ewing tumor-associated antigen 1
EXD3 exonuclease 3'-5' domain containing 3
F2R coagulation factor II (thrombin) receptor
FAM204A family with sequence similarity 204, member A
FBXO2 F-box protein 2
FBXO5 F-box protein 5
GEMIN8 gem (nuclear organelle) associated protein 8
GJA9 gap junction protein, alpha 9, 59kDa
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR143 G protein-coupled receptor 143
HDAC11 histone deacetylase 11
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HHAT hedgehog acyltransferase
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2BM histone cluster 1, H2bm
HIST2H2AA3 histone cluster 2, H2aa3
HOXA4 homeobox A4
HOXC5 homeobox C5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL12RB1 interleukin 12 receptor, beta 1
IL4R interleukin 4 receptor
INF2 inverted formin, FH2 and WH2 domain containing
INO80D INO80 complex subunit D
INPP1 inositol polyphosphate-1-phosphatase
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KITLG KIT ligand
KPNA5 karyopherin alpha 5 (importin alpha 6)
LARP6 La ribonucleoprotein domain family, member 6
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIF leukemia inhibitory factor
LIN7A lin-7 homolog A (C. elegans)
LMNB1 lamin B1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBNL3 muscleblind-like splicing regulator 3
MEFV Mediterranean fever
NAT6 N-acetyltransferase 6 (GCN5-related)
NIPAL2 NIPA-like domain containing 2
NPY1R neuropeptide Y receptor Y1
NUP62CL nucleoporin 62kDa C-terminal like
NXPE3 neurexophilin and PC-esterase domain family, member 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OSGIN1 oxidative stress induced growth inhibitor 1
PEX26 peroxisomal biogenesis factor 26
PRAMEF11 PRAME family member 11
PRR4 proline rich 4 (lacrimal)
PVRL3 poliovirus receptor-related 3
RCAN3 RCAN family member 3
RGS19 regulator of G-protein signaling 19
SIX1 SIX homeobox 1
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SNX16 sorting nexin 16
SP1 Sp1 transcription factor
SRD5A3 steroid 5 alpha-reductase 3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM2 transmembrane protein 2
TRABD TraB domain containing
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM36 tripartite motif containing 36
TSGA10 testis specific, 10
UPP1 uridine phosphorylase 1
VASH2 vasohibin 2
ZIC3 Zic family member 3
ZNF286A zinc finger protein 286A
ZNF747 zinc finger protein 747