spaglumic acid-7465 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the spaglumic acid-7465 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
B9D2 B9 protein domain 2
BCL2 B-cell CLL/lymphoma 2
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CENPO centromere protein O
CES3 carboxylesterase 3
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CLTA clathrin, light chain A
COL1A1 collagen, type I, alpha 1
COL4A2 collagen, type IV, alpha 2
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CPT1A carnitine palmitoyltransferase 1A (liver)
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DNAH17 dynein, axonemal, heavy chain 17
DNM1 dynamin 1
DOCK6 dedicator of cytokinesis 6
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FBXL2 F-box and leucine-rich repeat protein 2
FGF2 fibroblast growth factor 2 (basic)
FLOT1 flotillin 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GAMT guanidinoacetate N-methyltransferase
GAS6 growth arrest-specific 6
GPATCH2L G patch domain containing 2-like
GPR21 G protein-coupled receptor 21
GRTP1 growth hormone regulated TBC protein 1
GSTM4 glutathione S-transferase mu 4
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HEMK1 HemK methyltransferase family member 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXB5 homeobox B5
IDS iduronate 2-sulfatase
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITPK1 inositol-tetrakisphosphate 1-kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM8 lysine (K)-specific demethylase 8
LOC390998 ribosomal protein L10 pseudogene
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MID1 midline 1
MINK1 misshapen-like kinase 1
MPZL1 myelin protein zero-like 1
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NF1 neurofibromin 1
NUP214 nucleoporin 214kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PAQR6 progestin and adipoQ receptor family member VI
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHGC3 protocadherin gamma subfamily C, 3
PHC3 polyhomeotic homolog 3 (Drosophila)
PLAUR plasminogen activator, urokinase receptor
PLEKHA6 pleckstrin homology domain containing, family A member 6
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
RAB40C RAB40C, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RARA retinoic acid receptor, alpha
RCAN3 RCAN family member 3
RECQL5 RecQ protein-like 5
REEP1 receptor accessory protein 1
RNF122 ring finger protein 122
RNF123 ring finger protein 123
RTEL1 regulator of telomere elongation helicase 1
RUNDC3A RUN domain containing 3A
SFTPB surfactant protein B
SH2D4A SH2 domain containing 4A
SIPA1 signal-induced proliferation-associated 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLMO1 slowmo homolog 1 (Drosophila)
SORBS3 sorbin and SH3 domain containing 3
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STAT5B signal transducer and activator of transcription 5B
STC1 stanniocalcin 1
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TAOK1 TAO kinase 1
TBCD tubulin folding cofactor D
TCP11L1 t-complex 11, testis-specific-like 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TP53I11 tumor protein p53 inducible protein 11
TRAK1 trafficking protein, kinesin binding 1
TSC22D3 TSC22 domain family, member 3
TSC22D4 TSC22 domain family, member 4
TTC9 tetratricopeptide repeat domain 9
TTLL3 tubulin tyrosine ligase-like family member 3
UMPS uridine monophosphate synthetase
VARS valyl-tRNA synthetase
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
WDTC1 WD and tetratricopeptide repeats 1
WNT1 wingless-type MMTV integration site family, member 1
YIPF4 Yip1 domain family, member 4
ZBED1 zinc finger, BED-type containing 1
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
AHDC1 AT hook, DNA binding motif, containing 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASB6 ankyrin repeat and SOCS box containing 6
BAGE B melanoma antigen
BCCIP BRCA2 and CDKN1A interacting protein
BPGM 2,3-bisphosphoglycerate mutase
C11ORF30 chromosome 11 open reading frame 30
C19ORF40 chromosome 19 open reading frame 40
C6ORF47 chromosome 6 open reading frame 47
CAPRIN2 caprin family member 2
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CFAP44 cilia and flagella associated protein 44
CNGB3 cyclic nucleotide gated channel beta 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL4A5 collagen, type IV, alpha 5
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTC1 CTS telomere maintenance complex component 1
DEAF1 DEAF1 transcription factor
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EPHA2 EPH receptor A2
FAN1 FANCD2/FANCI-associated nuclease 1
FBXO3 F-box protein 3
FBXO31 F-box protein 31
FCHO1 FCH domain only 1
FER fer (fps/fes related) tyrosine kinase
FMO4 flavin containing monooxygenase 4
FPGS folylpolyglutamate synthase
FSD1 fibronectin type III and SPRY domain containing 1
GAB2 GRB2-associated binding protein 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GCHFR GTP cyclohydrolase I feedback regulator
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HINFP histone H4 transcription factor
HIST1H4D histone cluster 1, H4d
HMOX1 heme oxygenase 1
IL17RA interleukin 17 receptor A
IL4R interleukin 4 receptor
IRF6 interferon regulatory factor 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA0125 KIAA0125
KIFAP3 kinesin-associated protein 3
LHX1 LIM homeobox 1
LOC642236 FSHD region gene 1 pseudogene
LRRC61 leucine rich repeat containing 61
MAGOHB mago-nashi homolog B (Drosophila)
MBOAT2 membrane bound O-acyltransferase domain containing 2
MCOLN3 mucolipin 3
MED9 mediator complex subunit 9
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYO1D myosin ID
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
ORAI3 ORAI calcium release-activated calcium modulator 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAQR3 progestin and adipoQ receptor family member III
PDZD8 PDZ domain containing 8
PFDN6 prefoldin subunit 6
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGP phosphoglycolate phosphatase
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PODXL2 podocalyxin-like 2
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNF126P1 ring finger protein 126 pseudogene 1
RPL13P5 ribosomal protein L13 pseudogene 5
RPL23AP32 ribosomal protein L23a pseudogene 32
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD1A SET domain containing 1A
SKA1 spindle and kinetochore associated complex subunit 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SRD5A3 steroid 5 alpha-reductase 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD5 StAR-related lipid transfer (START) domain containing 5
STBD1 starch binding domain 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THRAP3 thyroid hormone receptor associated protein 3
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM180 transmembrane protein 180
TMEM209 transmembrane protein 209
TMSB15B thymosin beta 15B
TPST1 tyrosylprotein sulfotransferase 1
TRIM52 tripartite motif containing 52
VAX2 ventral anterior homeobox 2
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF180 zinc finger protein 180
ZNF302 zinc finger protein 302
ZNF557 zinc finger protein 557
ZNF668 zinc finger protein 668